SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4az7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 222
ALA A 516
LEU A 530
LEU A 277
ALA A 194
 None
 0.88A 1bzfA-4az7A:
undetectable		 1bzfA-4az7A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.24A 1h7xA-4az7A:
5.1		 1h7xA-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.23A 1h7xB-4az7A:
10.5		 1h7xB-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.23A 1h7xC-4az7A:
6.5		 1h7xC-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 ASN A 225
SER A 437
ASN A 356
THR A 291
 LOG  A1614 ( 4.2A)
None
None
None
 1.23A 1h7xD-4az7A:
2.0		 1h7xD-4az7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 245
SER A 236
ASP A 248
ASP A 234
 None
 0.90A 1yc5A-4az7A:
undetectable		 1yc5A-4az7A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 358
ILE A 301
GLY A 224
VAL A 223
ILE A 341
 None
 1.14A 2avsB-4az7A:
undetectable		 2avsB-4az7A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 227
TYR A 261
ASP A 299
ALA A 300
ALA A 304
 None
 1.00A 2br4A-4az7A:
undetectable		 2br4A-4az7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 227
TYR A 261
ASP A 299
ALA A 300
ALA A 304
 None
 0.99A 2br4E-4az7A:
undetectable		 2br4E-4az7A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 11 MET A 274
LEU A 288
ALA A 194
SER A 191
LEU A 219
 None
 1.16A 2c12F-4az7A:
3.6		 2c12F-4az7A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 9 GLN A 273
ASN A 267
ALA A 194
VAL A 223
PHE A 230
 None
 1.22A 2drdA-4az7A:
undetectable		 2drdA-4az7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A 288
GLY A 287
LEU A 219
ILE A 208
ILE A 278
 None
 0.99A 2f8dA-4az7A:
undetectable		 2f8dA-4az7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A 288
GLY A 287
LEU A 219
ILE A 208
ILE A 278
 None
 0.95A 2f8dB-4az7A:
undetectable		 2f8dB-4az7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_D_BEZD2002_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 9 LEU A 484
ASN A 475
GLN A 479
GLY A 473
LEU A 472
 None
 1.37A 2ok6B-4az7A:
0.0
2ok6D-4az7A:
0.0		 2ok6B-4az7A:
22.72
2ok6D-4az7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 10 LEU A 484
ASN A 475
GLN A 479
GLY A 473
LEU A 472
 None
 1.38A 2ok6A-4az7A:
undetectable
2ok6H-4az7A:
undetectable		 2ok6A-4az7A:
22.72
2ok6H-4az7A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 SER A 191
ILE A 192
ASP A 193
ARG A 196
 None
None
None
LOG  A1614 (-2.8A)
 1.11A 2v57A-4az7A:
undetectable		 2v57A-4az7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 SER A 191
ILE A 192
ASP A 193
ARG A 196
 None
None
None
LOG  A1614 (-2.8A)
 1.11A 2v57C-4az7A:
undetectable		 2v57C-4az7A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 7 ILE A 357
ILE A 237
LEU A 359
LEU A 228
 None
 0.85A 3adxA-4az7A:
undetectable		 3adxA-4az7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 6 TYR A 397
ALA A 398
LEU A 401
THR A 291
 None
 0.88A 3b6hA-4az7A:
undetectable		 3b6hA-4az7A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 227
ASP A 193
ASP A 263
GLY A 256
ASP A 226
 None
 0.89A 3bwcB-4az7A:
undetectable		 3bwcB-4az7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 196
ASP A 226
HIS A 297
ASP A 360
TRP A 439
TYR A 469
 LOG  A1614 (-2.8A)
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
 0.81A 3lmyA-4az7A:
27.2		 3lmyA-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 196
HIS A 297
ASP A 360
TRP A 439
TYR A 469
TRP A 517
 LOG  A1614 (-2.8A)
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
LOG  A1614 (-3.8A)
 0.50A 3lmyA-4az7A:
27.2		 3lmyA-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		7 / 12 ARG A 196
ASP A 226
HIS A 297
ASP A 360
GLU A 361
TRP A 439
TYR A 469
 LOG  A1614 (-2.8A)
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.0A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
 0.83A 3lmyB-4az7A:
27.3		 3lmyB-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 196
ASP A 226
HIS A 297
GLU A 361
TYR A 482
 LOG  A1614 (-2.8A)
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.0A)
LOG  A1614 (-4.4A)
 1.44A 3lmyB-4az7A:
27.3		 3lmyB-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		7 / 12 ARG A 196
HIS A 297
ASP A 360
GLU A 361
TRP A 439
TYR A 469
TRP A 517
 LOG  A1614 (-2.8A)
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
LOG  A1614 (-3.0A)
LOG  A1614 (-3.4A)
LOG  A1614 (-4.3A)
LOG  A1614 (-3.8A)
 0.57A 3lmyB-4az7A:
27.3		 3lmyB-4az7A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 358
ILE A 301
GLY A 224
VAL A 223
ILE A 341
 None
 1.00A 3nu5B-4az7A:
undetectable		 3nu5B-4az7A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 544
THR A 497
GLU A 182
 None
None
EDO  A1621 (-4.8A)
 0.75A 4df3A-4az7A:
undetectable		 4df3A-4az7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 TYR A 544
THR A 497
GLU A 182
 None
None
EDO  A1621 (-4.8A)
 0.77A 4df3B-4az7A:
undetectable		 4df3B-4az7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 519
ASP A 193
ASP A 299
ASN A 225
 LOG  A1614 (-2.8A)
None
None
LOG  A1614 ( 4.2A)
 1.09A 4feuB-4az7A:
undetectable		 4feuB-4az7A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 281
LEU A 277
LEU A 221
SER A 191
SER A 200
 None
 1.09A 4ky8C-4az7A:
undetectable		 4ky8C-4az7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 215
ASP A 548
ILE A 189
GLY A 512
PHE A 537
 None
 1.24A 4obwC-4az7A:
undetectable		 4obwC-4az7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 364
ASP A 360
ASP A 193
 None
LOG  A1614 (-3.9A)
None
 0.66A 4obwD-4az7A:
undetectable		 4obwD-4az7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 281
LEU A 277
LEU A 221
SER A 191
SER A 200
 None
 1.13A 4q0dC-4az7A:
undetectable		 4q0dC-4az7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 281
LEU A 277
LEU A 221
SER A 191
SER A 200
 None
 1.13A 4q0dD-4az7A:
undetectable		 4q0dD-4az7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A 582
LYS A 575
GLU A 578
 None
 0.58A 5d0yA-4az7A:
undetectable		 5d0yA-4az7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 THR A 567
THR A 611
PRO A 560
LEU A 563
 None
 0.90A 5g48A-4az7A:
undetectable		 5g48A-4az7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 269
LEU A 228
GLY A 227
ILE A 253
ALA A 304
 None
 1.33A 5j7wC-4az7A:
undetectable		 5j7wC-4az7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 LYS A 212
ASP A 209
ILE A 189
 None
 0.87A 5kc4E-4az7A:
undetectable		 5kc4E-4az7A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 MET A 235
ALA A 346
VAL A 249
LEU A 228
VAL A 223
 None
 1.17A 5tudD-4az7A:
3.3		 5tudD-4az7A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 10 THR A 217
GLY A 511
ILE A 510
ILE A 354
ILE A 289
 None
 1.10A 6ebpD-4az7A:
undetectable		 6ebpD-4az7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 11 THR A 217
GLY A 511
ILE A 510
ILE A 354
ILE A 289
 None
 1.06A 6ebzA-4az7A:
undetectable		 6ebzA-4az7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 11 THR A 217
GLY A 511
ILE A 510
ILE A 354
ILE A 289
 None
 1.05A 6ebzC-4az7A:
undetectable		 6ebzC-4az7A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 THR A 606
ALA A 577
LYS A 579
 None
 0.72A 6fgcA-4az7A:
undetectable		 6fgcA-4az7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 THR A 606
ALA A 577
LYS A 579
 None
 0.71A 6fgdA-4az7A:
undetectable		 6fgdA-4az7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 364
GLY A 195
HIS A 297
ASP A 360
 None
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
 0.91A 6gh9A-4az7A:
undetectable		 6gh9A-4az7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 364
GLY A 227
HIS A 297
ASP A 360
 None
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
 0.89A 6gh9A-4az7A:
undetectable		 6gh9A-4az7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 269
LEU A 228
GLY A 227
ILE A 253
ALA A 304
 None
 1.32A 6qxsD-4az7A:
undetectable		 6qxsD-4az7A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4az7 BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 269
LEU A 228
GLY A 227
ILE A 253
ALA A 304
 None
 1.36A 6qyaB-4az7A:
undetectable		 6qyaB-4az7A:
22.73