SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4azc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 886
ALA A 888
SER A 889
GLY A 852
TYR A 825
 None
 1.16A 1nbiC-4azcA:
undetectable		 1nbiC-4azcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 TYR A 886
ALA A 888
SER A 889
GLY A 852
TYR A 825
 None
 1.17A 1nbiD-4azcA:
undetectable		 1nbiD-4azcA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 0.98A 2br4A-4azcA:
undetectable		 2br4A-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 0.96A 2br4B-4azcA:
undetectable		 2br4B-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 1.02A 2br4C-4azcA:
undetectable		 2br4C-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 0.96A 2br4E-4azcA:
undetectable		 2br4E-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 672
TYR A 706
ASP A 744
ALA A 745
ALA A 749
 None
 1.02A 2br4F-4azcA:
undetectable		 2br4F-4azcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 11 LEU A 887
LEU A 868
ILE A 869
THR A 897
LEU A 931
 None
None
None
MG  A2045 (-4.7A)
None
 1.26A 3a50C-4azcA:
undetectable		 3a50C-4azcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 887
LEU A 868
ILE A 869
THR A 897
LEU A 931
 None
None
None
MG  A2045 (-4.7A)
None
 1.25A 3a50E-4azcA:
undetectable		 3a50E-4azcA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 672
ASP A 638
ASP A 708
GLY A 701
ASP A 671
 None
 0.94A 3bwcB-4azcA:
undetectable		 3bwcB-4azcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 921
GLY A 924
THR A 923
 None
 0.52A 3iazA-4azcA:
undetectable		 3iazA-4azcA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 641
ASP A 671
HIS A 742
ASP A 804
TRP A 872
TYR A 902
 NGW  A2042 (-2.9A)
None
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
NGW  A2042 (-3.7A)
MG  A2045 ( 4.4A)
 0.91A 3lmyA-4azcA:
27.2		 3lmyA-4azcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		6 / 12 ARG A 641
HIS A 742
ASP A 804
TRP A 872
TYR A 902
TRP A 951
 NGW  A2042 (-2.9A)
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
NGW  A2042 (-3.7A)
MG  A2045 ( 4.4A)
NGW  A2042 (-3.8A)
 0.54A 3lmyA-4azcA:
27.2		 3lmyA-4azcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		7 / 12 ARG A 641
ASP A 671
HIS A 742
ASP A 804
GLU A 805
TRP A 872
TYR A 902
 NGW  A2042 (-2.9A)
None
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
NGW  A2042 (-3.2A)
NGW  A2042 (-3.7A)
MG  A2045 ( 4.4A)
 0.88A 3lmyB-4azcA:
27.3		 3lmyB-4azcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		7 / 12 ARG A 641
HIS A 742
ASP A 804
GLU A 805
TRP A 872
TYR A 902
TRP A 951
 NGW  A2042 (-2.9A)
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
NGW  A2042 (-3.2A)
NGW  A2042 (-3.7A)
MG  A2045 ( 4.4A)
NGW  A2042 (-3.8A)
 0.56A 3lmyB-4azcA:
27.3		 3lmyB-4azcA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 783
ASN A 779
ILE A 737
VAL A 694
ILE A 682
 None
 1.00A 3lzvB-4azcA:
undetectable		 3lzvB-4azcA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 HIS A 665
GLY A 669
LEU A 666
ASN A 800
ALA A 745
 None
 1.25A 3vywB-4azcA:
undetectable		 3vywB-4azcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 804
SER A 739
MET A 770
GLY A 669
 NGW  A2042 (-3.6A)
None
None
None
 1.01A 4af0A-4azcA:
4.7		 4af0A-4azcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 7 ASP A 953
ASP A 638
ASP A 744
ASN A 670
 NGW  A2042 (-2.9A)
None
None
NGW  A2042 ( 4.5A)
 1.03A 4feuB-4azcA:
undetectable		 4feuB-4azcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 953
ASP A 638
ASP A 744
ASN A 670
 NGW  A2042 (-2.9A)
None
None
NGW  A2042 ( 4.5A)
 1.21A 4fewD-4azcA:
undetectable		 4fewD-4azcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 953
ASP A 638
ASP A 744
ASN A 670
 NGW  A2042 (-2.9A)
None
None
NGW  A2042 ( 4.5A)
 1.18A 4fewF-4azcA:
undetectable		 4fewF-4azcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 953
ASP A 638
ASP A 744
ASN A 670
 NGW  A2042 (-2.9A)
None
None
NGW  A2042 ( 4.5A)
 1.20A 4gkiA-4azcA:
undetectable		 4gkiA-4azcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 8 ASP A 953
ASP A 638
ASP A 744
ASN A 670
 NGW  A2042 (-2.9A)
None
None
NGW  A2042 ( 4.5A)
 1.20A 4gkiC-4azcA:
undetectable		 4gkiC-4azcA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 808
ASP A 804
ASP A 638
 None
NGW  A2042 (-3.6A)
None
 0.71A 4obwD-4azcA:
undetectable		 4obwD-4azcA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 714
LEU A 673
GLY A 672
ILE A 698
ALA A 749
 None
 1.32A 5j7wC-4azcA:
undetectable		 5j7wC-4azcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 9 TYR A 978
ILE A 635
ILE A 652
LEU A 649
 None
 0.83A 5vkqB-4azcA:
undetectable
5vkqC-4azcA:
undetectable		 5vkqB-4azcA:
12.92
5vkqC-4azcA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 919
GLY A 924
LYS A 925
ASP A 911
GLY A 912
 None
 1.25A 5wwsB-4azcA:
undetectable		 5wwsB-4azcA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 808
GLY A 640
HIS A 742
ASP A 804
 None
None
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
 0.89A 6gh9A-4azcA:
undetectable		 6gh9A-4azcA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A 808
GLY A 672
HIS A 742
ASP A 804
 None
None
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
 0.85A 6gh9A-4azcA:
undetectable		 6gh9A-4azcA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		4 / 7 TRP A 816
ASP A 763
THR A 811
HIS A 742
 None
None
None
NGW  A2042 (-4.0A)
 1.46A 6nmfN-4azcA:
undetectable
6nmfP-4azcA:
undetectable		 6nmfN-4azcA:
21.22
6nmfP-4azcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 714
LEU A 673
GLY A 672
ILE A 698
ALA A 749
 None
 1.30A 6qxsD-4azcA:
undetectable		 6qxsD-4azcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 714
LEU A 673
GLY A 672
ILE A 698
ALA A 749
 None
 1.34A 6qyaB-4azcA:
undetectable		 6qyaB-4azcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4azc BETA-N-ACETYLHEXOSAM
INIDASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 714
LEU A 673
GLY A 672
ILE A 698
ALA A 749
 None
 1.34A 6qyaD-4azcA:
undetectable		 6qyaD-4azcA:
21.71