SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4azd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 4azd ASPARTATE
1-DECARBOXYLASE
(Escherichia
coli) 		4 / 7 SER A  70
SER A  25
ALA A  27
ILE A  60
 None
MLI  A1120 (-2.5A)
None
MLI  A1120 (-4.0A)
 0.99A 1fxhA-4azdA:
undetectable
1fxhB-4azdA:
undetectable		 1fxhA-4azdA:
19.91
1fxhB-4azdA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 4azd ASPARTATE
1-DECARBOXYLASE
(Escherichia
coli) 		5 / 11 ILE A  69
ILE A  87
MET A 114
GLY A  65
LEU A  33
 None
 1.14A 2azyA-4azdA:
undetectable		 2azyA-4azdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4azd ASPARTATE
1-DECARBOXYLASE
(Escherichia
coli) 		5 / 10 GLY A  65
ALA A  62
PHE A  32
PHE A 108
LEU A  10
 None
 1.41A 3a3yA-4azdA:
undetectable		 3a3yA-4azdA:
8.75