SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		4 / 8 TYR A  29
LEU A  25
LEU A  59
GLU A  92
 None
 1.08A 1i7zA-4b09A:
undetectable		 1i7zA-4b09A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		4 / 4 LEU A 212
SER A 173
LEU A 161
LEU A 159
 None
 0.86A 1yajA-4b09A:
3.0		 1yajA-4b09A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		5 / 12 ALA A 164
LEU A 189
LYS A 206
ARG A 209
THR A 162
 None
 1.19A 3ix9A-4b09A:
undetectable		 3ix9A-4b09A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		4 / 7 MET A  63
LEU A  62
GLU A  17
HIS A  42
 None
 1.18A 4aq7A-4b09A:
3.7		 4aq7A-4b09A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		3 / 3 LEU A  25
ASP A  28
TYR A  29
 None
 0.53A 4qc6B-4b09A:
undetectable		 4qc6B-4b09A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		4 / 4 ILE A  58
ILE A  82
ARG A  77
LEU A  59
 None
 1.35A 5dzkh-4b09A:
undetectable
5dzkn-4b09A:
undetectable
5dzkv-4b09A:
undetectable		 5dzkh-4b09A:
22.39
5dzkn-4b09A:
22.39
5dzkv-4b09A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		4 / 5 ARG A 209
ILE A 205
GLY A 229
ILE A 222
 None
 0.88A 5dzki-4b09A:
undetectable
5dzkj-4b09A:
undetectable
5dzkx-4b09A:
undetectable		 5dzki-4b09A:
22.39
5dzkj-4b09A:
22.39
5dzkx-4b09A:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		3 / 3 ARG A 199
ASN A 207
ASP A 160
 None
 0.78A 5gwxA-4b09A:
2.9		 5gwxA-4b09A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		4 / 6 VAL A  16
GLN A  45
VAL A  46
TYR A  49
 None
 0.72A 5i8fA-4b09A:
undetectable		 5i8fA-4b09A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 4b09 TRANSCRIPTIONAL
REGULATORY PROTEIN
BAER
(Escherichia
coli) 		5 / 12 PRO A  83
ILE A  82
ILE A  84
VAL A  50
ILE A  76
 None
None
CAS  A  73 ( 4.3A)
None
CAS  A  73 ( 4.3A)
 1.15A 6hlpA-4b09A:
4.5		 6hlpA-4b09A:
19.07