SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b0a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 333
ILE A 270
ILE A 306
VAL A 266
PHE A 268
 None
 1.34A 1gx9A-4b0aA:
2.0		 1gx9A-4b0aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 7 LYS A 318
SER A  29
VAL A 171
THR A 173
VAL A 222
 None
None
None
GOL  A1070 ( 4.1A)
None
 1.37A 3em0B-4b0aA:
undetectable		 3em0B-4b0aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 THR A 212
VAL A 222
THR A 224
VAL A 171
 GOL  A1242 (-3.8A)
None
GOL  A1243 (-3.0A)
None
 0.32A 3em0B-4b0aA:
undetectable		 3em0B-4b0aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 305
ILE A 294
ARG A 296
 None
None
GOL  A1241 (-3.5A)
 0.70A 4mk4B-4b0aA:
undetectable		 4mk4B-4b0aA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 270
LEU A 275
ILE A 306
ILE A 312
VAL A 266
 None
 0.84A 4y0rA-4b0aA:
2.0		 4y0rA-4b0aA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 293
LEU A 304
ILE A 330
PRO A 165
LEU A 314
 None
 1.35A 5g48B-4b0aA:
undetectable		 5g48B-4b0aA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  19
PHE A 216
ILE A  32
PHE A  23
ILE A 243
 GOL  A1070 ( 4.9A)
None
GOL  A1243 (-4.5A)
GOL  A1070 (-3.7A)
None
 1.19A 6mkeA-4b0aA:
undetectable
6mkeD-4b0aA:
undetectable		 6mkeA-4b0aA:
20.20
6mkeD-4b0aA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4b0a TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1,
LINKER,
TATA-BOX-BINDING
PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  19
PHE A 216
ILE A  32
PHE A  23
ILE A 243
 GOL  A1070 ( 4.9A)
None
GOL  A1243 (-4.5A)
GOL  A1070 (-3.7A)
None
 1.19A 6mkeB-4b0aA:
undetectable
6mkeC-4b0aA:
undetectable		 6mkeB-4b0aA:
20.20
6mkeC-4b0aA:
20.20