SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 ALA A 311
ASP A 312
LEU A 315
ILE A 338
LEU A 347
 None
 1.25A 1errA-4b0nA:
undetectable		 1errA-4b0nA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 4 LEU A 135
VAL A 221
CYH A 220
ALA A 197
 None
 1.28A 1mz9E-4b0nA:
undetectable		 1mz9E-4b0nA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 LEU A 125
VAL A 133
ALA A 132
LEU A 166
ASP A 171
 None
None
None
MLA  A1415 (-4.1A)
None
 1.15A 2c12C-4b0nA:
undetectable		 2c12C-4b0nA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 GLY A 246
TYR A  92
TYR A  55
TYR A 362
SER A 367
 None
 1.49A 2zthA-4b0nA:
undetectable		 2zthA-4b0nA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 8 ARG A 380
TYR A 392
GLN A 342
GLU A 350
 None
 1.22A 3dh0A-4b0nA:
undetectable		 3dh0A-4b0nA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 8 SER A 162
GLY A 190
SER A 367
ASN A 199
 None
MLA  A1415 ( 3.5A)
None
None
 0.97A 3lslA-4b0nA:
undetectable
3lslD-4b0nA:
undetectable		 3lslA-4b0nA:
20.72
3lslD-4b0nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 11 ASP A 171
LEU A 174
VAL A 136
ALA A 132
PHE A 165
 None
None
None
None
MLA  A1415 (-4.3A)
 1.14A 3n23C-4b0nA:
undetectable		 3n23C-4b0nA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 GLY A 200
ILE A 189
ASP A 171
LEU A 157
ARG A 186
 None
 1.11A 3o7wA-4b0nA:
undetectable		 3o7wA-4b0nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 5 PHE A 165
LEU A 284
GLY A 193
VAL A 160
 MLA  A1415 (-4.3A)
ACD  A1416 (-4.3A)
ACD  A1416 ( 4.3A)
None
 1.03A 3wrkD-4b0nA:
undetectable		 3wrkD-4b0nA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 8 GLY A 333
LEU A 239
ASN A 364
PHE A 243
 None
None
None
ACD  A1416 (-4.9A)
 1.06A 4m5mA-4b0nA:
undetectable		 4m5mA-4b0nA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 8 ALA A 244
ASN A 364
ARG A  91
HIS A 240
 None
None
ACD  A1416 (-3.4A)
ACD  A1416 (-3.9A)
 1.23A 5db5A-4b0nA:
undetectable
5db5B-4b0nA:
undetectable		 5db5A-4b0nA:
21.14
5db5B-4b0nA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 PHE A 230
VAL A  65
PHE A  98
ILE A  88
PHE A  93
 ACD  A1416 (-4.7A)
None
ACD  A1416 (-4.1A)
None
ACD  A1416 ( 4.5A)
 1.18A 5hkgA-4b0nA:
undetectable		 5hkgA-4b0nA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 ASP A 206
ILE A 267
ALA A 266
GLY A 200
GLY A 408
 None
 0.97A 5i73A-4b0nA:
0.9		 5i73A-4b0nA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 7 VAL A 221
LEU A 223
LEU A 170
LEU A 174
 None
 0.67A 5jq7A-4b0nA:
undetectable		 5jq7A-4b0nA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 9 ILE A 144
GLY A  47
ILE A  45
VAL A 158
ILE A 219
 None
 1.16A 5kr0A-4b0nA:
undetectable		 5kr0A-4b0nA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		5 / 12 VAL A 160
GLU A 222
ALA A 196
SER A 367
LEU A 284
 None
None
None
None
ACD  A1416 (-4.3A)
 1.39A 5nd2B-4b0nA:
undetectable		 5nd2B-4b0nA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4b0n POLYKETIDE SYNTHASE
III
(Ectocarpus
siliculosus) 		4 / 7 GLN A 342
GLY A 346
ILE A 307
TRP A 328
 None
 1.11A 5vlmC-4b0nA:
undetectable		 5vlmC-4b0nA:
18.32