SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		3 / 3 ASP A 208
GLU A  70
ARG A 422
 ADP  A1478 (-4.4A)
MG  A1479 ( 4.0A)
None
 0.74A 1wopA-4b0tA:
undetectable		 1wopA-4b0tA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A  63
ILE A  55
ILE A  92
ALA A  93
 None
 0.89A 2i30A-4b0tA:
undetectable		 2i30A-4b0tA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 11 GLY A 225
SER A 186
ILE A 182
SER A 183
ALA A 273
 None
 1.00A 2nnhA-4b0tA:
undetectable		 2nnhA-4b0tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		4 / 7 ASN A  57
SER A  59
TYR A  71
THR A  73
 None
None
None
ADP  A1478 (-3.9A)
 0.85A 2uz2A-4b0tA:
undetectable		 2uz2A-4b0tA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 12 ASN A  78
GLU A 309
ASN A 317
ARG A 322
VAL A 323
 None
 1.20A 3cb8A-4b0tA:
undetectable		 3cb8A-4b0tA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A  55
GLY A  58
ALA A 419
ALA A 409
ALA A  72
 None
None
None
None
ADP  A1478 ( 3.1A)
 1.01A 3jb2A-4b0tA:
undetectable		 3jb2A-4b0tA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		3 / 3 SER A 186
ASP A 226
ASN A 228
 None
 0.90A 3lslA-4b0tA:
undetectable
3lslD-4b0tA:
undetectable		 3lslA-4b0tA:
19.60
3lslD-4b0tA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		4 / 6 ILE A 234
ALA A 235
THR A  80
THR A 401
 None
 1.09A 3mdrA-4b0tA:
undetectable		 3mdrA-4b0tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 11 MET A 149
ILE A 266
VAL A 224
VAL A 189
ILE A 204
 None
 1.20A 3rf4A-4b0tA:
1.1
3rf4C-4b0tA:
0.9		 3rf4A-4b0tA:
15.38
3rf4C-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 11 ILE A 204
MET A 149
ILE A 266
VAL A 224
VAL A 189
 None
 1.22A 3rf4A-4b0tA:
1.0
3rf4B-4b0tA:
0.9		 3rf4A-4b0tA:
15.38
3rf4B-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 11 ILE A 204
MET A 149
ILE A 266
VAL A 224
VAL A 189
 None
 1.18A 3rf4B-4b0tA:
0.9
3rf4C-4b0tA:
0.9		 3rf4B-4b0tA:
15.38
3rf4C-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 9 ALA A  93
GLY A  89
LEU A  61
ASN A  57
ILE A  55
 None
 1.28A 3wdmA-4b0tA:
undetectable		 3wdmA-4b0tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A 324
ILE A 158
GLU A 335
ILE A 334
ALA A 333
 None
 1.05A 4ltwA-4b0tA:
undetectable		 4ltwA-4b0tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 9 THR A 206
GLU A 131
VAL A 244
LEU A 245
ILE A 248
 None
 1.17A 4r38C-4b0tA:
undetectable		 4r38C-4b0tA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		3 / 3 PRO A 210
ILE A 203
SER A 214
 None
 0.76A 5fsaA-4b0tA:
undetectable		 5fsaA-4b0tA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 422
HIS A 211
ARG A 418
 None
ADP  A1478 (-3.0A)
ADP  A1478 (-3.4A)
 1.16A 5iaoC-4b0tA:
undetectable		 5iaoC-4b0tA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		3 / 3 ARG A 422
HIS A 211
ARG A 418
 None
ADP  A1478 (-3.0A)
ADP  A1478 (-3.4A)
 1.14A 5iaoF-4b0tA:
undetectable		 5iaoF-4b0tA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		4 / 6 LEU A 152
ILE A 334
MET A 330
TRP A 348
 None
 1.04A 5ljeA-4b0tA:
undetectable		 5ljeA-4b0tA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		5 / 12 VAL A  98
LEU A 407
GLN A 392
ARG A 385
GLY A 384
 None
 1.19A 5m50E-4b0tA:
undetectable		 5m50E-4b0tA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		4 / 7 SER A 270
HIS A 165
GLY A 179
ARG A 163
 None
 1.04A 6btxA-4b0tA:
undetectable		 6btxA-4b0tA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 4b0t PUP--PROTEIN LIGASE
(Corynebacterium
glutamicum) 		4 / 5 GLU A 131
VAL A 222
LEU A 152
THR A 241
 None
 1.24A 6dyoA-4b0tA:
undetectable		 6dyoA-4b0tA:
10.49