SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
3 / 3 LEU A  99
HIS A 112
ILE A 108
None
0.71A 1s9pB-4b0zA:
undetectable
1s9pB-4b0zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
3 / 3 PRO A  40
THR A  41
LEU A  37
None
0.78A 3ttrA-4b0zA:
undetectable
3ttrA-4b0zA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
5 / 12 PHE A 124
LEU A  99
GLU A 116
ALA A 114
THR A 113
None
1.17A 4fiaA-4b0zA:
undetectable
4fiaA-4b0zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
5 / 12 PHE A 124
LEU A  99
GLU A 116
ALA A 114
THR A 113
None
1.17A 4fiaA-4b0zA:
undetectable
4fiaA-4b0zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
4 / 5 LEU A 195
ASP A 146
GLU A 174
VAL A 167
None
1.33A 4nkvA-4b0zA:
undetectable
4nkvA-4b0zA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
4 / 6 LEU A  97
PHE A 160
ILE A 166
PHE A 163
None
1.08A 4y4dA-4b0zA:
undetectable
4y4dA-4b0zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
5 / 12 ALA A  74
ILE A  62
SER A  69
GLY A  92
ILE A  78
None
SGM  A1226 (-4.7A)
None
None
None
1.12A 5m24A-4b0zA:
undetectable
5m24A-4b0zA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA612_1
(SERUM ALBUMIN)
4b0z 26S PROTEASOME
REGULATORY SUBUNIT
RPN12

(Schizosaccharomy
ces
pombe)
5 / 12 GLU A 209
LEU A 197
ILE A 175
ALA A 176
GLU A 180
None
1.18A 5v0vA-4b0zA:
2.3
5v0vA-4b0zA:
17.59