SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b18'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 PHE A 174
LEU A 135
ALA A 148
ALA A 192
THR A 162
 None
 1.09A 1cbsA-4b18A:
undetectable		 1cbsA-4b18A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 ARG A 397
ALA A 443
THR A 405
ALA A 400
 None
 0.97A 1w0gA-4b18A:
undetectable		 1w0gA-4b18A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 305
LEU A 317
ILE A 362
LEU A 347
LEU A 344
 None
 1.05A 2bdmA-4b18A:
undetectable		 2bdmA-4b18A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 LEU A 208
GLY A 194
ASN A 238
ALA A 235
ALA A 232
 None
 1.06A 2bm9C-4b18A:
undetectable		 2bm9C-4b18A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A 422
GLY A 423
LEU A 419
ILE A 404
PHE A 382
 None
 1.09A 2f8dA-4b18A:
undetectable		 2f8dA-4b18A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 PHE A 174
LEU A 135
ALA A 148
ALA A 192
THR A 162
 None
 1.09A 2fr3A-4b18A:
undetectable		 2fr3A-4b18A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 10 PHE A 131
ILE A 154
ALA A 170
VAL A 150
PHE A 106
 None
 1.32A 3ay0A-4b18A:
undetectable		 3ay0A-4b18A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 ILE A 472
ILE A 481
LEU A 499
GLU A 448
LEU A 451
 None
 1.30A 3f78A-4b18A:
undetectable		 3f78A-4b18A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 9 ILE A 472
ILE A 481
LEU A 499
GLU A 448
LEU A 451
 None
 1.34A 3f78B-4b18A:
undetectable		 3f78B-4b18A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 12 ARG A 397
ARG A 395
ALA A 443
THR A 405
ALA A 400
 None
 1.25A 3ua1A-4b18A:
undetectable		 3ua1A-4b18A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 GLY A 169
ILE A 166
GLN A 167
VAL A 128
 None
 1.00A 4d39B-4b18A:
undetectable		 4d39B-4b18A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 GLY A 169
ILE A 166
GLN A 167
VAL A 128
 None
 1.05A 4kcnA-4b18A:
undetectable		 4kcnA-4b18A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 5 TYR A 503
ILE A 481
PRO A 467
THR A 408
 None
 1.24A 4ze1A-4b18A:
undetectable		 4ze1A-4b18A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 ALA A 235
ASN A 238
LEU A 239
 None
 0.39A 5i1nB-4b18A:
undetectable		 5i1nB-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 ALA A 235
ASN A 238
LEU A 239
 None
 0.32A 5i1oC-4b18A:
undetectable		 5i1oC-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 ALA A 235
ASN A 238
LEU A 239
 None
 0.48A 5i1oA-4b18A:
undetectable		 5i1oA-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 ALA A 235
ASN A 238
LEU A 239
 None
 0.22A 5i1pA-4b18A:
undetectable		 5i1pA-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		3 / 3 ALA A 235
ASN A 238
LEU A 239
 None
 0.35A 5i1pD-4b18A:
undetectable		 5i1pD-4b18A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		5 / 10 LEU A 432
ILE A 450
PHE A 382
ALA A 401
LEU A 389
 None
 1.24A 5y7pB-4b18A:
undetectable		 5y7pB-4b18A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4b18 IMPORTIN SUBUNIT
ALPHA-1
(Homo
sapiens) 		4 / 6 ARG A 397
ALA A 443
THR A 405
ALA A 400
 None
 1.01A 6ma6A-4b18A:
undetectable		 6ma6A-4b18A:
10.32