SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 GLY A  74
VAL A 159
LEU A 163
LEU A 105
ILE A 193
 None
 0.91A 1mx1D-4b28A:
undetectable		 1mx1D-4b28A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		4 / 7 MET A 229
ALA A 249
ARG A 284
ASN A 245
 None
 1.22A 1t9wA-4b28A:
undetectable		 1t9wA-4b28A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 10 GLN A 423
ILE A 334
LEU A 350
VAL A 382
LEU A 397
 None
 1.02A 3gwxA-4b28A:
undetectable		 3gwxA-4b28A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 VAL A 178
LEU A 186
GLY A 136
ALA A 137
LEU A 139
 None
 0.94A 3pghC-4b28A:
undetectable		 3pghC-4b28A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 VAL A 178
LEU A 186
GLY A 136
ALA A 137
LEU A 139
 None
 0.98A 3rr3A-4b28A:
undetectable		 3rr3A-4b28A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 12 VAL A 178
LEU A 186
GLY A 136
ALA A 137
LEU A 139
 None
 0.99A 3rr3B-4b28A:
undetectable		 3rr3B-4b28A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 HIS A 333
HIS A 329
ILE A 409
 None
 0.75A 3u52A-4b28A:
undetectable
3u52C-4b28A:
undetectable		 3u52A-4b28A:
21.00
3u52C-4b28A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		3 / 3 TYR A 366
ASP A 307
ASP A 422
 None
FE  A1446 ( 2.2A)
None
 0.77A 4a6eA-4b28A:
undetectable		 4a6eA-4b28A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 10 VAL A 178
LEU A 186
GLY A 136
ALA A 137
LEU A 139
 None
 1.07A 4ph9B-4b28A:
undetectable		 4ph9B-4b28A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		4 / 6 LEU A  76
LEU A 183
PHE A  78
LEU A 139
 None
 0.95A 5gs4A-4b28A:
undetectable		 5gs4A-4b28A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 10 GLU A 192
GLY A 190
LEU A 170
ARG A 172
ALA A  73
 None
 1.10A 5o96E-4b28A:
undetectable
5o96F-4b28A:
undetectable		 5o96E-4b28A:
21.23
5o96F-4b28A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		5 / 10 LEU A 163
GLU A 192
GLY A 190
LEU A 170
ALA A  73
 None
 1.18A 5o96E-4b28A:
undetectable
5o96F-4b28A:
undetectable		 5o96E-4b28A:
21.23
5o96F-4b28A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b28 METALLOPEPTIDASE,
FAMILY M24, PUTATIVE
(Roseobacter
denitrificans) 		4 / 5 ARG A 257
LEU A  37
GLN A  36
PHE A  39
 None
 1.44A 6nmpP-4b28A:
undetectable
6nmpW-4b28A:
undetectable		 6nmpP-4b28A:
18.12
6nmpW-4b28A:
7.26