SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b2g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 7 HIS A 250
THR A 256
TYR A 210
LEU A 214
 None
 1.14A 1qzrA-4b2gA:
undetectable		 1qzrA-4b2gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 7 HIS A 250
THR A 256
TYR A 210
LEU A 214
 None
 1.12A 1qzrB-4b2gA:
undetectable		 1qzrB-4b2gA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 12 LEU A 505
CYH A 509
LEU A 511
ALA A 512
GLU A 515
 None
 1.05A 1s9pC-4b2gA:
undetectable		 1s9pC-4b2gA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 4 LEU A 322
SER A 326
TYR A 325
LEU A 235
 None
None
MLI  A1598 (-4.3A)
None
 1.31A 1xz1A-4b2gA:
undetectable		 1xz1A-4b2gA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 4 LEU A 322
SER A 326
TYR A 325
LEU A 235
 None
None
MLI  A1598 (-4.3A)
None
 1.33A 1xz3A-4b2gA:
undetectable		 1xz3A-4b2gA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 6 TYR A 132
SER A 195
GLN A 212
ASP A 308
 None
 1.25A 2cl5B-4b2gA:
undetectable		 2cl5B-4b2gA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 6 GLU A 103
ALA A 407
LEU A  96
THR A 405
 None
 1.03A 2roxB-4b2gA:
undetectable		 2roxB-4b2gA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 7 ILE A 442
THR A 479
MET A 315
LEU A 235
 None
 0.95A 2xrhA-4b2gA:
undetectable		 2xrhA-4b2gA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 7 VAL A 567
TYR A 489
LYS A 571
GLU A 574
 None
 1.29A 3hs4A-4b2gA:
undetectable		 3hs4A-4b2gA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 12 LEU A 401
GLY A 344
LEU A 134
SER A 133
ALA A 365
 None
 1.17A 3i5uB-4b2gA:
undetectable		 3i5uB-4b2gA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 8 PHE A 343
ASP A 416
TYR A 336
LEU A 409
 None
V1N  A1600 (-2.8A)
None
None
 0.95A 3jq7B-4b2gA:
undetectable		 3jq7B-4b2gA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 4 GLY A 151
TYR A 153
GLY A 227
ASP A 308
 None
 1.07A 3kl3A-4b2gA:
undetectable		 3kl3A-4b2gA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		3 / 3 SER A 530
GLY A 524
SER A 444
 None
None
MLI  A1599 (-3.3A)
 0.49A 3loqA-4b2gA:
undetectable		 3loqA-4b2gA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 10 LEU A 152
GLY A 295
ILE A 296
VAL A 223
LEU A 226
 None
 1.09A 3ogpB-4b2gA:
undetectable		 3ogpB-4b2gA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 10 LEU A 152
GLY A 295
ILE A 296
VAL A 223
LEU A 226
 None
 1.00A 3ogpA-4b2gA:
undetectable		 3ogpA-4b2gA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 8 TYR A 342
LEU A 173
SER A 444
SER A 108
 V1N  A1600 (-4.4A)
MLI  A1599 (-3.9A)
MLI  A1599 (-3.3A)
V1N  A1600 ( 2.5A)
 1.10A 3rodA-4b2gA:
undetectable		 3rodA-4b2gA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 12 MET A 130
THR A  30
GLN A 429
LEU A 347
LEU A 345
 None
 1.45A 4qztA-4b2gA:
undetectable		 4qztA-4b2gA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		3 / 3 VAL A 420
HIS A 392
VAL A 388
 None
 0.69A 5jmnC-4b2gA:
2.2		 5jmnC-4b2gA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 5 TYR A 177
TYR A 193
TYR A 132
ARG A 185
 None
 1.15A 5mthH-4b2gA:
undetectable
5mthL-4b2gA:
undetectable		 5mthH-4b2gA:
17.56
5mthL-4b2gA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 12 MET A 209
PHE A 154
ILE A 482
LEU A 234
ALA A 228
 None
 1.27A 5oy02-4b2gA:
undetectable		 5oy02-4b2gA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		5 / 12 LEU A 452
PHE A 585
VAL A 456
ALA A 455
LEU A 517
 None
 1.22A 6ajiA-4b2gA:
undetectable		 6ajiA-4b2gA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		4 / 5 TYR A 489
GLU A 535
TYR A 318
HIS A 485
 None
 1.34A 6ep4A-4b2gA:
undetectable		 6ep4A-4b2gA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 4b2g GH3-1 AUXIN
CONJUGATING ENZYME
(Vitis
vinifera) 		3 / 3 HIS A 372
ARG A 434
ILE A 417
 None
 0.67A 6fgdA-4b2gA:
undetectable		 6fgdA-4b2gA:
22.04