SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 GLY A 172
LEU A 173
GLY A 142
TYR A 117
MET A 111
 None
 1.11A 1fduC-4b2nA:
undetectable		 1fduC-4b2nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 7 TYR A 515
HIS A 368
TYR A 367
GLY A 363
 HEM  A 701 (-4.7A)
None
None
None
 1.26A 1mxgA-4b2nA:
undetectable		 1mxgA-4b2nA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 LEU A 221
LEU A 220
GLY A 219
MET A 599
ARG A 227
 None
 1.37A 1p93A-4b2nA:
undetectable		 1p93A-4b2nA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 TRP A 537
VAL A 521
PRO A 522
 None
 0.68A 1rg1A-4b2nA:
undetectable		 1rg1A-4b2nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 TRP A 537
VAL A 521
PRO A 522
 None
 0.67A 1rh0A-4b2nA:
undetectable		 1rh0A-4b2nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 5 ILE A 381
SER A 389
ARG A 370
ASN A 378
 None
 1.19A 1y0xX-4b2nA:
undetectable		 1y0xX-4b2nA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 THR A 512
PRO A 514
PRO A 212
 None
 0.90A 2d55C-4b2nA:
undetectable		 2d55C-4b2nA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 5 LEU A 169
PRO A 170
LEU A 173
ILE A 187
 None
 0.70A 2qd4A-4b2nA:
undetectable		 2qd4A-4b2nA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 7 ILE A 174
MET A 111
GLN A 109
LEU A 240
 None
 1.02A 2qqcB-4b2nA:
undetectable
2qqcC-4b2nA:
undetectable		 2qqcB-4b2nA:
11.54
2qqcC-4b2nA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 7 LEU A 240
ILE A 174
MET A 111
GLN A 109
 None
 1.03A 2qqcA-4b2nA:
undetectable
2qqcF-4b2nA:
undetectable		 2qqcA-4b2nA:
5.44
2qqcF-4b2nA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 7 LEU A 240
ILE A 174
MET A 111
GLN A 109
 None
 1.07A 2qqcI-4b2nA:
undetectable
2qqcL-4b2nA:
undetectable		 2qqcI-4b2nA:
5.44
2qqcL-4b2nA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 5 PRO A 155
PRO A 153
TYR A 152
TYR A 117
 None
 1.11A 3d9lA-4b2nA:
undetectable
3d9lY-4b2nA:
undetectable		 3d9lA-4b2nA:
10.39
3d9lY-4b2nA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 5 PRO A 476
ILE A 479
PRO A 485
TYR A 480
 None
 1.30A 3d9lA-4b2nA:
undetectable
3d9lY-4b2nA:
undetectable		 3d9lA-4b2nA:
10.39
3d9lY-4b2nA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 SER A 392
ALA A  59
VAL A 396
GLY A 415
LEU A 506
 HEM  A 701 ( 4.1A)
None
None
None
HEM  A 701 (-4.6A)
 1.04A 3ln1D-4b2nA:
undetectable		 3ln1D-4b2nA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 ALA A 218
GLY A 247
SER A 248
MET A 285
ALA A 222
 HEM  A 700 ( 4.9A)
None
None
None
None
 1.26A 3ou6C-4b2nA:
undetectable		 3ou6C-4b2nA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 ALA A 218
GLY A 247
SER A 248
MET A 285
ALA A 222
 HEM  A 700 ( 4.9A)
None
None
None
None
 1.24A 3ou7C-4b2nA:
undetectable		 3ou7C-4b2nA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 ARG A 626
ARG A 246
ILE A 618
 None
 0.95A 4b7qA-4b2nA:
undetectable		 4b7qA-4b2nA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 SER A 347
VAL A  43
ALA A  22
PHE A 296
LEU A 413
 None
 1.23A 4ib4A-4b2nA:
undetectable		 4ib4A-4b2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 VAL A  30
VAL A  43
ALA A  22
PHE A 296
LEU A 413
 None
 1.13A 4ib4A-4b2nA:
undetectable		 4ib4A-4b2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.13A 4jksA-4b2nA:
undetectable		 4jksA-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.14A 4jksB-4b2nA:
undetectable		 4jksB-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.13A 4jkuA-4b2nA:
undetectable		 4jkuA-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_2
(SUGAR KINASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.15A 4k8cB-4b2nA:
0.0		 4k8cB-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_2
(SUGAR KINASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.15A 4k8kA-4b2nA:
undetectable		 4k8kA-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_2
(SUGAR KINASE)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.16A 4k8kB-4b2nA:
0.0		 4k8kB-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.14A 4kalB-4b2nA:
undetectable		 4kalB-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 GLU A 337
ARG A  84
HIS A  71
 None
 0.79A 4kf9A-4b2nA:
undetectable		 4kf9A-4b2nA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.13A 4lcaA-4b2nA:
undetectable		 4lcaA-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 4 SER A 389
LEU A 528
TYR A 367
PRO A 384
 None
None
None
HEM  A 701 ( 4.9A)
 1.15A 4lcaB-4b2nA:
undetectable		 4lcaB-4b2nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 SER A 347
VAL A  43
ALA A  22
PHE A 296
LEU A 413
 None
 1.27A 4nc3A-4b2nA:
undetectable		 4nc3A-4b2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 12 VAL A  30
VAL A  43
ALA A  22
PHE A 296
LEU A 413
 None
 1.19A 4nc3A-4b2nA:
undetectable		 4nc3A-4b2nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		5 / 9 ASP A 217
GLY A 142
LEU A 143
LEU A 173
ALA A 193
 None
None
None
None
HEM  A 700 ( 4.9A)
 1.08A 5dqfA-4b2nA:
undetectable		 5dqfA-4b2nA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 6 PRO A 348
TYR A 515
PRO A 505
LEU A 506
 None
HEM  A 701 (-4.7A)
None
HEM  A 701 (-4.6A)
 1.18A 5tl8A-4b2nA:
undetectable		 5tl8A-4b2nA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		4 / 7 TRP A 525
TRP A 653
ASP A 561
TYR A 560
 None
 1.29A 5vlmG-4b2nA:
undetectable		 5vlmG-4b2nA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 TYR A 152
PRO A 170
LEU A 173
 None
 0.91A 6beoA-4b2nA:
undetectable		 6beoA-4b2nA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 4b2n 70 KDA PROTEIN
(Xanthomonas
sp.
35Y) 		3 / 3 ARG A 246
ARG A 626
ASP A 217
 None
 0.83A 6d8pA-4b2nA:
undetectable		 6d8pA-4b2nA:
23.36