SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b2o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 THR A 232
THR A 233
PRO A 201
 None
 0.84A 1a7yA-4b2oA:
undetectable		 1a7yA-4b2oA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.91A 1fb7A-4b2oA:
undetectable		 1fb7A-4b2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 GLY A 236
VAL A 237
ILE A 193
ARG A 253
GLY A 197
 None
 0.99A 1fohA-4b2oA:
2.6		 1fohA-4b2oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 GLY A 236
VAL A 237
ILE A 193
ARG A 253
GLY A 197
 None
 0.99A 1fohB-4b2oA:
1.9		 1fohB-4b2oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 GLY A 236
VAL A 237
ILE A 193
ARG A 253
GLY A 197
 None
 0.95A 1fohC-4b2oA:
2.2		 1fohC-4b2oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 GLY A 236
VAL A 237
ILE A 193
ARG A 253
GLY A 197
 None
 0.94A 1fohD-4b2oA:
2.2		 1fohD-4b2oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.97A 1hsgB-4b2oA:
undetectable		 1hsgB-4b2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 THR A 232
THR A 233
PRO A 201
 None
 0.84A 1qfiA-4b2oA:
undetectable		 1qfiA-4b2oA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.93A 1sdtB-4b2oA:
undetectable		 1sdtB-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 1.01A 1sduB-4b2oA:
undetectable		 1sduB-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 7 PHE A 146
THR A 174
VAL A 237
GLY A 236
 None
 0.88A 2a1mA-4b2oA:
undetectable		 2a1mA-4b2oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 8 THR A 174
VAL A 237
GLY A 236
ILE A  35
 None
 0.80A 2a1mB-4b2oA:
undetectable		 2a1mB-4b2oA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 9 PHE A 146
THR A 174
VAL A 237
GLY A 236
ILE A  35
 None
 1.13A 2a1oB-4b2oA:
undetectable		 2a1oB-4b2oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 9 PHE A 146
VAL A 237
GLY A 236
ASP A 148
ILE A  35
 None
 1.15A 2a1oB-4b2oA:
undetectable		 2a1oB-4b2oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.91A 2aquA-4b2oA:
undetectable		 2aquA-4b2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 11 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.91A 2aquB-4b2oA:
undetectable		 2aquB-4b2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 ILE A 251
ILE A 193
ILE A 147
ALA A 248
ILE A 239
 None
 0.89A 2b60A-4b2oA:
undetectable		 2b60A-4b2oA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.93A 2f80A-4b2oA:
undetectable		 2f80A-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.96A 2f81A-4b2oA:
undetectable		 2f81A-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.92A 2f8gA-4b2oA:
undetectable		 2f8gA-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.87A 2hs2B-4b2oA:
undetectable		 2hs2B-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
ILE A  35
VAL A   9
 None
 0.73A 2o4sB-4b2oA:
undetectable		 2o4sB-4b2oA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 ASP A  61
THR A 142
PRO A 143
 None
 0.62A 2pynB-4b2oA:
undetectable		 2pynB-4b2oA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
ILE A  35
VAL A   9
 None
 0.79A 2q5kB-4b2oA:
undetectable		 2q5kB-4b2oA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 ASP A  61
THR A 142
PRO A 143
 None
 0.62A 2q64B-4b2oA:
undetectable		 2q64B-4b2oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 ASP A  61
THR A 142
PRO A 143
 None
 0.64A 2qakB-4b2oA:
undetectable		 2qakB-4b2oA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.97A 2qhcB-4b2oA:
undetectable		 2qhcB-4b2oA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 11 GLY A  59
ALA A  60
ASP A  61
ILE A  35
VAL A   9
 None
 0.80A 2r5qB-4b2oA:
undetectable		 2r5qB-4b2oA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 SER A  54
SER A  58
VAL A   9
GLY A  11
ALA A  41
 None
 1.12A 2x2iA-4b2oA:
2.3		 2x2iA-4b2oA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 SER A  54
SER A  58
VAL A   9
GLY A  11
ALA A  41
 None
 1.22A 2x2iC-4b2oA:
undetectable		 2x2iC-4b2oA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.87A 2z54A-4b2oA:
undetectable		 2z54A-4b2oA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 10 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.92A 3ekyA-4b2oA:
undetectable		 3ekyA-4b2oA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 11 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.86A 3el1A-4b2oA:
undetectable		 3el1A-4b2oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 11 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.94A 3em4A-4b2oA:
undetectable		 3em4A-4b2oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 11 GLY A  59
ALA A  60
ASP A  61
LEU A  25
VAL A   9
 None
 0.85A 3em4U-4b2oA:
undetectable		 3em4U-4b2oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 11 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.91A 3em4U-4b2oA:
undetectable		 3em4U-4b2oA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 ARG A 216
ASP A  71
GLN A 116
 None
 0.89A 3lcvB-4b2oA:
undetectable		 3lcvB-4b2oA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 VAL A   9
VAL A  22
SER A  58
 None
 0.70A 3n8xB-4b2oA:
undetectable		 3n8xB-4b2oA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.85A 3ndwA-4b2oA:
undetectable		 3ndwA-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.85A 3ndxA-4b2oA:
undetectable		 3ndxA-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
VAL A   9
ILE A  36
 None
 0.87A 3pwmB-4b2oA:
undetectable		 3pwmB-4b2oA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 THR A 199
GLY A 200
GLY A 207
HIS A 177
ASP A  16
 None
None
None
FE2  A1266 ( 3.3A)
None
 1.38A 3tkaA-4b2oA:
undetectable		 3tkaA-4b2oA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 ASP A  61
THR A 142
PRO A 143
 None
 0.64A 3tkgD-4b2oA:
undetectable		 3tkgD-4b2oA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 7 ALA A  89
GLU A 137
LEU A 134
TRP A  70
 None
 1.03A 4iomA-4b2oA:
3.1		 4iomA-4b2oA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 HIS A 177
ASP A   8
ASN A  40
LEU A  47
HIS A 150
 FE2  A1266 ( 3.3A)
FE2  A1266 (-3.1A)
FE2  A1266 ( 2.5A)
None
FE2  A1267 (-3.3A)
 1.27A 5dv4A-4b2oA:
5.1		 5dv4A-4b2oA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 6 PHE A  78
VAL A  82
MET A  65
ILE A  63
 None
 0.90A 5iwuA-4b2oA:
undetectable		 5iwuA-4b2oA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 LEU A 134
ILE A 135
ARG A 167
VAL A 171
TYR A 163
 None
 1.24A 5vlmE-4b2oA:
undetectable		 5vlmE-4b2oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 7 ASN A  67
HIS A  68
GLY A 207
ASN A  40
 PO4  A1265 ( 2.6A)
PO4  A1265 (-3.7A)
None
FE2  A1266 ( 2.5A)
 0.70A 5x7pA-4b2oA:
2.3		 5x7pA-4b2oA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 7 HIS A  68
ASP A   8
GLY A 207
ASN A  40
 PO4  A1265 (-3.7A)
FE2  A1266 (-3.1A)
None
FE2  A1266 ( 2.5A)
 0.96A 5x7pA-4b2oA:
2.3		 5x7pA-4b2oA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		3 / 3 TYR A 202
HIS A 260
MET A 261
 None
 0.96A 6af6A-4b2oA:
undetectable		 6af6A-4b2oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CM4_A_8NUA2001_1
(D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 4 ASP A 243
ALA A 191
SER A 169
PHE A  33
 None
 0.97A 6cm4A-4b2oA:
0.0		 6cm4A-4b2oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_1
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
ILE A  35
VAL A   9
 None
 0.73A 6dj1B-4b2oA:
undetectable		 6dj1B-4b2oA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		5 / 12 GLY A  59
ALA A  60
ASP A  61
ILE A  35
VAL A   9
 None
 0.76A 6dj2B-4b2oA:
undetectable		 6dj2B-4b2oA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 5 LEU A 234
THR A 199
THR A 232
GLY A  14
 None
 1.08A 6gtqA-4b2oA:
undetectable		 6gtqA-4b2oA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 4b2o YMDB
PHOSPHODIESTERASE
(Bacillus
subtilis) 		4 / 7 GLY A 197
HIS A  68
ASN A  40
GLY A 207
 None
PO4  A1265 (-3.7A)
FE2  A1266 ( 2.5A)
None
 0.93A 6n7fA-4b2oA:
undetectable		 6n7fA-4b2oA:
19.31