SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b2q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 ILE D 344
MET D 459
VAL D 165
GLY D 343
 None
None
ADP  D1476 (-4.2A)
None
 1.14A 1e06B-4b2qD:
undetectable		 1e06B-4b2qD:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 LYS H 109
LEU H 105
ALA H 108
LEU H 104
 None
 1.44A 1f86B-4b2qH:
undetectable		 1f86B-4b2qH:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ASP D 349
LEU D 317
ASP D 315
THR D 332
 None
 0.97A 1rmtD-4b2qD:
undetectable		 1rmtD-4b2qD:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ALA H  87
LEU H  16
ALA H  90
LEU H  32
VAL H  57
 None
 1.07A 2bxeA-4b2qH:
undetectable		 2bxeA-4b2qH:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 141
ASP D 142
SER D 355
GLY D 151
ILE D 153
 None
 1.40A 2dcfA-4b2qD:
undetectable		 2dcfA-4b2qD:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 THR D 185
VAL D 218
VAL D  98
ARG D 295
 None
 0.74A 2ij7C-4b2qD:
undetectable		 2ij7C-4b2qD:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 LYS H 109
LEU H 105
ALA H 108
LEU H 104
 None
 1.47A 2roxA-4b2qH:
undetectable		 2roxA-4b2qH:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE D  62
LEU D 234
PHE D 261
GLN D 282
ARG D 274
 None
 1.27A 2w3mB-4b2qD:
undetectable		 2w3mB-4b2qD:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 141
ASP D 142
SER D 355
GLY D 151
ILE D 153
 None
 1.41A 3a65A-4b2qD:
undetectable		 3a65A-4b2qD:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 GLU D 169
GLY D 137
THR D 136
GLU D 135
 None
 0.94A 3e9xA-4b2qD:
undetectable		 3e9xA-4b2qD:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 GLY D 462
GLN D 416
VAL D 432
ASP D 436
VAL D 466
 None
 1.46A 3fi0M-4b2qD:
undetectable		 3fi0M-4b2qD:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLY D  88
GLY D 236
PHE D 184
LEU D 217
ALA D 240
 None
 1.07A 3kkzB-4b2qD:
undetectable		 3kkzB-4b2qD:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 VAL H  85
LEU H  52
ILE H  70
VAL H  30
 None
 0.83A 4a9kA-4b2qH:
undetectable		 4a9kA-4b2qH:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 PRO D 350
ASP D 349
ILE D 344
VAL D 161
 None
None
None
ADP  D1476 (-4.4A)
 1.14A 4hytA-4b2qD:
undetectable		 4hytA-4b2qD:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LYS D  45
LEU D  46
THR D  61
ALA D  63
ALA D 228
 None
 1.12A 4x1iB-4b2qD:
2.6		 4x1iB-4b2qD:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ALA D 264
ASP D 256
GLU D 193
GLU D 189
THR D 164
 None
None
MG  D1477 ( 4.1A)
MG  D1477 (-4.1A)
MG  D1477 ( 3.4A)
 1.48A 4zjoA-4b2qD:
0.0		 4zjoA-4b2qD:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 141
LEU D 431
GLY D 137
ASP D 142
ILE D 174
 None
 1.23A 5b8hA-4b2qD:
undetectable
5b8hB-4b2qD:
undetectable		 5b8hA-4b2qD:
21.85
5b8hB-4b2qD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL D 141
LEU D 431
GLY D 137
ASP D 142
ILE D 174
 None
 1.23A 5b8hA-4b2qD:
undetectable
5b8hB-4b2qD:
undetectable		 5b8hA-4b2qD:
21.85
5b8hB-4b2qD:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 LEU D 217
SER D 182
PHE D 181
GLU D 247
 None
 0.93A 5b8iA-4b2qD:
undetectable		 5b8iA-4b2qD:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 SER D 353
ARG D 337
GLY D 338
GLU D 341
 None
 1.11A 5btiA-4b2qD:
undetectable
5btiB-4b2qD:
undetectable		 5btiA-4b2qD:
23.68
5btiB-4b2qD:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 SER D 353
ARG D 337
GLY D 338
GLU D 341
 None
 1.19A 5btiC-4b2qD:
undetectable
5btiD-4b2qD:
undetectable		 5btiC-4b2qD:
23.68
5btiD-4b2qD:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 SER D 353
ASP D 315
ARG D 337
GLY D 338
 None
 0.94A 5cdqA-4b2qD:
undetectable
5cdqC-4b2qD:
undetectable
5cdqD-4b2qD:
undetectable		 5cdqA-4b2qD:
23.51
5cdqC-4b2qD:
23.51
5cdqD-4b2qD:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ILE D 296
ILE D 258
THR D 185
VAL D 183
VAL D 251
 None
 0.90A 5jkwA-4b2qD:
undetectable		 5jkwA-4b2qD:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4b2q ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 LEU H 105
VAL H 129
GLN H 134
GLU H  99
 None
 0.77A 5tudA-4b2qH:
3.0		 5tudA-4b2qH:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLU D  49
ALA D 230
GLY D 227
LEU D 234
PHE D 261
 None
 1.15A 5w7pA-4b2qD:
2.1		 5w7pA-4b2qD:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4b2q ATP SYNTHASE SUBUNIT
B, MITOCHONDRIAL
(Bos
taurus) 		3 / 3 PHE T 125
ARG T 129
GLN T 128
 None
 0.73A 6g1pB-4b2qT:
undetectable		 6g1pB-4b2qT:
17.68