SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b3g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 ALA A   5
VAL A  10
TRP A 386
 None
 0.95A 1grmA-4b3gA:
undetectable		 1grmA-4b3gA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 ALA A   5
VAL A  10
TRP A 386
 None
 0.95A 1grmB-4b3gA:
undetectable		 1grmB-4b3gA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 4 GLY A  58
LEU A  59
GLY A  61
ARG A  62
 None
 1.06A 1j7kA-4b3gA:
2.5		 1j7kA-4b3gA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKT_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 10 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.42A 1qktA-4b3gA:
undetectable		 1qktA-4b3gA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 12 LEU A 166
LEU A 209
LEU A 390
LEU A 155
TYR A 158
 None
 1.12A 1sqnB-4b3gA:
undetectable		 1sqnB-4b3gA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 5 MET A 423
ALA A 427
ILE A 211
ASP A 400
 None
 1.03A 1upfA-4b3gA:
2.9		 1upfA-4b3gA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 5 MET A 423
ALA A 427
ILE A 211
ASP A 400
 None
 1.04A 1upfC-4b3gA:
undetectable		 1upfC-4b3gA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 4 HIS A 213
ASP A 375
ASN A 352
ASP A 400
 None
 1.46A 1wg8A-4b3gA:
0.0		 1wg8A-4b3gA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 SER A 614
VAL A 636
LEU A 490
 None
 0.38A 1yajG-4b3gA:
undetectable		 1yajG-4b3gA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 6 PRO A 268
LEU A 280
ARG A 270
GLY A 354
 None
None
A  G   8 ( 3.6A)
A  G   8 ( 4.3A)
 0.94A 2hs2B-4b3gA:
undetectable		 2hs2B-4b3gA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 ARG A 443
GLN A 403
PRO A 216
 None
 0.99A 2qhfA-4b3gA:
undetectable		 2qhfA-4b3gA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 12 SER A 582
ASN A 511
THR A 616
VAL A 617
LEU A 591
 None
 1.45A 2xrlA-4b3gA:
2.6		 2xrlA-4b3gA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 11 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.33A 3hm1B-4b3gA:
undetectable		 3hm1B-4b3gA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 6 PHE A 579
ALA A 600
THR A 602
ALA A 452
 None
 1.05A 3mdrB-4b3gA:
undetectable		 3mdrB-4b3gA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 SER A 180
SER A 205
HIS A 183
 None
 0.79A 3mzeA-4b3gA:
undetectable		 3mzeA-4b3gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 10 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.47A 3ollA-4b3gA:
undetectable		 3ollA-4b3gA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 5 GLU A 226
LEU A 229
GLN A 230
LYS A 233
 None
 0.45A 3pgyB-4b3gA:
undetectable		 3pgyB-4b3gA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 12 VAL A 348
LEU A 349
GLY A 354
ALA A 355
LEU A 361
 None
None
A  G   8 ( 4.3A)
None
None
 1.09A 4coxC-4b3gA:
undetectable		 4coxC-4b3gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 6 SER A 279
LEU A 280
ASP A 281
LEU A 263
 None
 0.78A 4wozA-4b3gA:
undetectable
4wozB-4b3gA:
undetectable		 4wozA-4b3gA:
18.74
4wozB-4b3gA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 10 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.45A 5dxeB-4b3gA:
undetectable		 5dxeB-4b3gA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 9 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.42A 5dxgA-4b3gA:
undetectable		 5dxgA-4b3gA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_A_BEZA601_0
(EUGENOL OXIDASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 9 VAL A 491
ILE A 611
LEU A 525
TYR A 642
ARG A 637
 None
 1.47A 5fxfA-4b3gA:
0.8		 5fxfA-4b3gA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 10 LEU A 389
GLU A 382
MET A 423
LEU A 426
ARG A 425
 None
 1.37A 5hyrA-4b3gA:
undetectable		 5hyrA-4b3gA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 12 ILE A 167
PHE A 171
LEU A 166
ALA A 151
VAL A   6
 None
 1.19A 5km9B-4b3gA:
undetectable		 5km9B-4b3gA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 THR A 602
PRO A 216
ASP A 400
 None
 0.84A 5l8dB-4b3gA:
undetectable		 5l8dB-4b3gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		3 / 3 THR A 602
PRO A 216
ASP A 400
 None
 0.84A 5mwuB-4b3gA:
undetectable		 5mwuB-4b3gA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 8 LEU A 166
GLU A 382
LEU A 397
ILE A 374
 None
 0.99A 5mzjA-4b3gA:
2.1		 5mzjA-4b3gA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 5 TYR A 629
SER A 453
ALA A 452
THR A 602
 None
 1.38A 5n0wB-4b3gA:
undetectable		 5n0wB-4b3gA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		5 / 10 ALA A 350
LEU A 280
LEU A 361
THR A 351
LEU A 342
 None
None
None
A  G   8 ( 2.6A)
None
 0.97A 6f5uA-4b3gA:
undetectable
6f5uB-4b3gA:
undetectable		 6f5uA-4b3gA:
9.60
6f5uB-4b3gA:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b3g DNA-BINDING PROTEIN
SMUBP-2
(Homo
sapiens) 		4 / 6 ARG A 297
LYS A 298
GLN A 302
PHE A 304
 None
 1.31A 6nmpC-4b3gA:
1.5
6nmpJ-4b3gA:
undetectable		 6nmpC-4b3gA:
17.24
6nmpJ-4b3gA:
7.31