SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b3k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 252
LEU A 269
LEU A 275
ALA A 197
PHE A 261
 None
 1.22A 1gseA-4b3kA:
undetectable		 1gseA-4b3kA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 11 LEU A 294
ALA A 197
ALA A 256
MET A 253
LEU A 225
 None
 1.11A 1iiuA-4b3kA:
undetectable		 1iiuA-4b3kA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 294
ALA A 197
ALA A 256
MET A 253
LEU A 225
 None
 1.09A 1kt5A-4b3kA:
undetectable		 1kt5A-4b3kA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 252
SER A 173
VAL A 138
ALA A 199
HIS A 118
 None
 1.39A 1q23D-4b3kA:
undetectable
1q23E-4b3kA:
undetectable		 1q23D-4b3kA:
16.80
1q23E-4b3kA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 197
ALA A 256
MET A 253
LEU A 225
HIS A 163
 None
 1.07A 1qabF-4b3kA:
undetectable		 1qabF-4b3kA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASP A  61
LEU A  62
HIS A 119
 None
 0.73A 1qknA-4b3kA:
undetectable		 1qknA-4b3kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 TRP A 247
LYS A 302
PRO A 319
 None
 1.46A 2dqyB-4b3kA:
1.8		 2dqyB-4b3kA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 7 THR A  14
ILE A 419
ASN A 437
GLN A  57
 None
 1.18A 2jc9A-4b3kA:
undetectable		 2jc9A-4b3kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 PHE A 145
CYH A 149
PHE A 153
 None
 1.15A 3cr5X-4b3kA:
undetectable		 3cr5X-4b3kA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 5 ASN A  29
THR A  14
SER A  76
ARG A  74
 None
 1.47A 3hlwB-4b3kA:
undetectable		 3hlwB-4b3kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 SER A  52
SER A  19
HIS A  56
 None
 0.65A 3mzeA-4b3kA:
undetectable		 3mzeA-4b3kA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 8 THR A 221
GLY A 295
LEU A 223
LEU A 296
 None
 0.91A 3nbqB-4b3kA:
undetectable		 3nbqB-4b3kA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 8 THR A 221
GLY A 295
LEU A 223
LEU A 296
 None
 0.90A 3nbqC-4b3kA:
undetectable		 3nbqC-4b3kA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 336
GLU A 374
GLY A 373
 None
 0.66A 3w9tA-4b3kA:
undetectable		 3w9tA-4b3kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  16
ILE A 115
VAL A 157
TYR A  98
ASN A 100
 None
 1.21A 4a81A-4b3kA:
undetectable		 4a81A-4b3kA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 TYR A  98
ALA A 105
TYR A  73
ILE A 419
GLY A  16
 None
 1.50A 4iilA-4b3kA:
undetectable		 4iilA-4b3kA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 121
TRP A 416
SER A  76
 None
 0.98A 4lrhB-4b3kA:
undetectable		 4lrhB-4b3kA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 121
TRP A 416
SER A  76
 None
 1.07A 4lrhF-4b3kA:
undetectable		 4lrhF-4b3kA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		5 / 12 SER A 314
PHE A 243
GLU A 171
LEU A 269
GLY A 186
 None
 1.29A 4zjlA-4b3kA:
undetectable		 4zjlA-4b3kA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 LEU A 294
PHE A 363
ILE A 222
 None
 0.77A 5dzk1-4b3kA:
undetectable
5dzkF-4b3kA:
1.7
5dzkM-4b3kA:
1.1		 5dzk1-4b3kA:
3.12
5dzkF-4b3kA:
18.35
5dzkM-4b3kA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 5 ALA A 255
ALA A 197
ILE A 286
LEU A 283
 None
 0.64A 5jncD-4b3kA:
undetectable		 5jncD-4b3kA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 4 GLN A 442
THR A 441
GLU A 436
LEU A  64
 None
 1.42A 5m66A-4b3kA:
undetectable		 5m66A-4b3kA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 269
VAL A 274
TYR A 322
HIS A 242
 None
 1.01A 5nu7A-4b3kA:
undetectable		 5nu7A-4b3kA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 5 GLN A 385
ASP A 386
SER A 449
ARG A 389
 None
 1.33A 5w4zA-4b3kA:
8.1		 5w4zA-4b3kA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ARG A 376
GLY A 373
GLU A 374
 None
 0.41A 6fgdA-4b3kA:
undetectable		 6fgdA-4b3kA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 8 TRP A 424
HIS A 119
HIS A 300
GLU A 366
 None
 1.22A 6mn4D-4b3kA:
undetectable		 6mn4D-4b3kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4b3k BETA-GLUCOSIDASE
(Streptococcus
pyogenes) 		4 / 7 TRP A 424
HIS A 119
HIS A 300
GLU A 366
 None
 1.29A 6mn4E-4b3kA:
undetectable		 6mn4E-4b3kA:
20.00