SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		3 / 3 TRP A 158
VAL A 259
TRP A 340
 None
None
MAL  A 500 (-3.9A)
 1.30A 1c4dA-4b3nA:
undetectable
1c4dB-4b3nA:
undetectable		 1c4dA-4b3nA:
5.21
1c4dB-4b3nA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 8 SER A 255
THR A 225
ASN A 150
LEU A 247
 None
 1.04A 1lhvA-4b3nA:
5.9		 1lhvA-4b3nA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 6 GLU A 214
ILE A  11
TYR A  17
GLY A  19
 None
 1.09A 1maaB-4b3nA:
undetectable
1maaD-4b3nA:
undetectable		 1maaB-4b3nA:
22.19
1maaD-4b3nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 7 LYS A 277
GLU A 281
ALA A 276
ALA A  77
 None
 1.16A 1sn0B-4b3nA:
undetectable
1sn0D-4b3nA:
undetectable		 1sn0B-4b3nA:
13.26
1sn0D-4b3nA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.16A 2f16H-4b3nA:
undetectable
2f16I-4b3nA:
undetectable		 2f16H-4b3nA:
19.75
2f16I-4b3nA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 11 THR A  93
GLN A 325
ALA A 324
ALA A 303
ALA A 301
 None
 1.14A 2f16V-4b3nA:
undetectable
2f16W-4b3nA:
undetectable		 2f16V-4b3nA:
19.75
2f16W-4b3nA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 11 ALA A 303
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 1.24A 2h42A-4b3nA:
undetectable		 2h42A-4b3nA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 0.85A 2h42C-4b3nA:
undetectable		 2h42C-4b3nA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 7 VAL A  97
ALA A 105
PHE A  92
PRO A  91
 None
 1.00A 2q6oA-4b3nA:
undetectable		 2q6oA-4b3nA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.97A 3bgdA-4b3nA:
undetectable		 3bgdA-4b3nA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.68A 3bjwC-4b3nA:
undetectable		 3bjwC-4b3nA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
 None
 1.06A 3hs6A-4b3nA:
undetectable		 3hs6A-4b3nA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 ILE A  60
ALA A 276
ASP A 267
ALA A 269
ILE A   9
 None
 1.05A 3jb1A-4b3nA:
undetectable		 3jb1A-4b3nA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MAL  A 500 ( 4.2A)
MAL  A 500 (-4.3A)
MAL  A 500 (-3.4A)
MAL  A 500 (-3.9A)
MAL  A 500 ( 4.4A)
MAL  A 500 (-3.9A)
 0.41A 3jyrA-4b3nA:
60.8		 3jyrA-4b3nA:
71.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		6 / 7 ASN A  12
TRP A  62
TYR A 155
MET A 330
TRP A 340
ARG A 344
 MAL  A 500 ( 4.2A)
MAL  A 500 (-4.3A)
MAL  A 500 (-3.9A)
MAL  A 500 ( 4.4A)
MAL  A 500 (-3.9A)
None
 0.58A 3jyrA-4b3nA:
60.8		 3jyrA-4b3nA:
71.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 6 GLY A1378
MET A1490
ILE A1406
VAL A1405
 None
 1.11A 3kvvB-4b3nA:
undetectable		 3kvvB-4b3nA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 6 GLY A1378
MET A1490
ILE A1406
VAL A1405
 None
 1.13A 3kvvD-4b3nA:
undetectable		 3kvvD-4b3nA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		3 / 3 ARG A1484
GLU A1395
ASN A1482
 None
 0.90A 4imaD-4b3nA:
undetectable		 4imaD-4b3nA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		3 / 3 ARG A1484
GLU A1395
ASN A1482
 None
 0.91A 4ip7D-4b3nA:
undetectable		 4ip7D-4b3nA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 4 TYR A1480
THR A1350
VAL A1322
ILE A1376
 None
 0.89A 4jx1F-4b3nA:
undetectable		 4jx1F-4b3nA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 ILE A 266
ALA A 105
LEU A  20
VAL A  23
ILE A  59
 None
 1.06A 4m2xG-4b3nA:
undetectable		 4m2xG-4b3nA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.16A 4or0B-4b3nA:
2.3		 4or0B-4b3nA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 4 VAL A 110
ALA A 112
ILE A 317
THR A 320
 None
 1.20A 5e4dB-4b3nA:
undetectable		 5e4dB-4b3nA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 8 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.83A 5f1aA-4b3nA:
undetectable		 5f1aA-4b3nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 7 LEU A  76
GLY A 265
ALA A 264
SER A 263
 None
 0.86A 5f1aB-4b3nA:
undetectable		 5f1aB-4b3nA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 TYR A1403
GLY A1402
VAL A1477
PHE A1478
ALA A1387
 None
 0.99A 5n0rA-4b3nA:
undetectable		 5n0rA-4b3nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 TYR A1403
GLY A1402
VAL A1477
PHE A1478
ALA A1387
 None
 1.00A 5n0wA-4b3nA:
undetectable		 5n0wA-4b3nA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.40A 5w4zA-4b3nA:
undetectable		 5w4zA-4b3nA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.42A 5w4zB-4b3nA:
undetectable		 5w4zB-4b3nA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.41A 6bm5A-4b3nA:
undetectable		 6bm5A-4b3nA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		4 / 4 VAL A1352
ALA A1306
PHE A1383
PHE A1478
 None
 1.43A 6cbdA-4b3nA:
2.0		 6cbdA-4b3nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5
(Escherichia
coli;
Macaca
mulatta) 		5 / 12 LEU A 275
GLY A  24
VAL A  35
LEU A   7
ILE A   9
 None
 0.99A 6ecxA-4b3nA:
undetectable		 6ecxA-4b3nA:
20.77