SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 PHE A 113
VAL A 115
ILE A 230
ILE A 149
LEU A  93
 None
 1.06A 1fm4A-4b43A:
undetectable		 1fm4A-4b43A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 1.09A 1hsgB-4b43A:
undetectable		 1hsgB-4b43A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 11 LEU A  90
GLY A 129
ILE A 125
PRO A  74
LEU A 227
 None
 1.21A 1p91A-4b43A:
undetectable		 1p91A-4b43A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 PHE A 177
ALA A 170
ALA A 168
LEU A 226
GLY A 172
 None
 1.19A 1qabF-4b43A:
undetectable		 1qabF-4b43A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.32A 1v8bA-4b43A:
2.2		 1v8bA-4b43A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.31A 1v8bB-4b43A:
2.2		 1v8bB-4b43A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.32A 1v8bD-4b43A:
undetectable		 1v8bD-4b43A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 11 LEU A 231
LEU A  93
ILE A 215
VAL A 148
ILE A 146
 None
 1.13A 2uxoB-4b43A:
undetectable		 2uxoB-4b43A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 VAL A  77
ILE A 125
LEU A 252
GLY A 320
ALA A 141
 None
 1.15A 2xf3A-4b43A:
undetectable		 2xf3A-4b43A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 ILE A 182
ILE A 213
ALA A 178
VAL A 192
PRO A 189
 None
 1.21A 3a51E-4b43A:
undetectable		 3a51E-4b43A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 VAL A 110
VAL A 250
ILE A 125
ARG A 299
 None
 1.08A 3ms9A-4b43A:
undetectable		 3ms9A-4b43A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 VAL A 110
VAL A 250
ILE A 125
ARG A 299
 None
 1.04A 3mssA-4b43A:
undetectable		 3mssA-4b43A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 VAL A 110
VAL A 250
ILE A 125
ARG A 299
 None
 1.05A 3mssC-4b43A:
undetectable		 3mssC-4b43A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.94A 3nu6B-4b43A:
undetectable		 3nu6B-4b43A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 1.02A 3nu9B-4b43A:
undetectable		 3nu9B-4b43A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 LEU A 196
PHE A 201
ILE A 149
ALA A 178
GLU A 237
 None
 1.06A 3nxuA-4b43A:
undetectable		 3nxuA-4b43A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 10 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 0.97A 3oy4B-4b43A:
undetectable		 3oy4B-4b43A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 9 VAL A 122
VAL A 123
VAL A 148
ILE A 146
ALA A 234
 None
 1.19A 4fwdA-4b43A:
2.9		 4fwdA-4b43A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 6 PRO A 247
GLY A 276
ALA A 302
GLN A 314
 None
 1.08A 4g0uA-4b43A:
undetectable		 4g0uA-4b43A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		3 / 3 MET A  15
GLU A  19
LEU A  23
 None
 0.42A 4v2oB-4b43A:
undetectable		 4v2oB-4b43A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.36A 5axdA-4b43A:
2.3		 5axdA-4b43A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.35A 5axdC-4b43A:
2.3		 5axdC-4b43A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 7 VAL A  46
LEU A  23
GLU A  44
ALA A  45
LEU A   9
 None
 1.33A 5jq7A-4b43A:
undetectable		 5jq7A-4b43A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 9 GLY A 303
ALA A 302
VAL A 310
GLY A 249
VAL A 110
 None
 1.00A 5kr0B-4b43A:
undetectable		 5kr0B-4b43A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 ALA A 284
PHE A 313
ARG A 248
GLN A 269
GLY A 320
 None
None
None
GOL  A1365 (-4.5A)
None
 1.12A 5m54E-4b43A:
undetectable		 5m54E-4b43A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.24A 5m5kB-4b43A:
2.7		 5m5kB-4b43A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.37A 5m66A-4b43A:
undetectable		 5m66A-4b43A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.40A 5m66C-4b43A:
undetectable		 5m66C-4b43A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 VAL A 326
GLU A 324
LEU A 329
ALA A 332
ARG A 339
 None
MG  A1361 (-4.1A)
None
None
MG  A1361 (-3.1A)
 1.27A 5nd4B-4b43A:
2.9		 5nd4B-4b43A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 HIS A 109
THR A 107
ASP A 126
THR A 127
ASP A  91
 None
 1.34A 5utuF-4b43A:
undetectable		 5utuF-4b43A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 ILE A 149
ALA A 147
ALA A 173
HIS A  84
LEU A  86
 None
 1.02A 6a60D-4b43A:
undetectable		 6a60D-4b43A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		4 / 5 PRO A  74
VAL A 122
GLY A 129
VAL A 148
 None
 1.09A 6ak3B-4b43A:
undetectable		 6ak3B-4b43A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4b43 TRANSLATION
INITIATION FACTOR
IF-2
(Thermus
thermophilus) 		5 / 12 VAL A  46
LEU A  24
GLU A  44
ALA A  43
LEU A  20
 None
 1.08A 6f6iA-4b43A:
0.5
6f6iB-4b43A:
undetectable		 6f6iA-4b43A:
12.69
6f6iB-4b43A:
12.40