SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 PHE A  98
LEU A 267
GLY A 197
ALA A 196
GLY A 191
 None
 1.15A 1igxA-4b45A:
undetectable		 1igxA-4b45A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 108
GLY A 102
LEU A 103
GLY A  71
VAL A  99
 GSP  A1342 (-4.0A)
GSP  A1342 ( 4.1A)
None
None
None
 1.16A 1jg2A-4b45A:
3.5		 1jg2A-4b45A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 11 GLY A  12
GLY A  13
VAL A  49
LEU A  47
LEU A 130
 None
 1.16A 1mx1A-4b45A:
3.0		 1mx1A-4b45A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_A_ADNA1301_1
(SUGAR KINASE MJ0406)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ALA A 263
GLY A 318
GLY A 317
ALA A 260
THR A 255
 None
 1.12A 2c49A-4b45A:
5.8		 2c49A-4b45A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ASP A  33
GLY A   7
VAL A   8
VAL A 127
ILE A  97
 None
 0.90A 2f8gA-4b45A:
undetectable		 2f8gA-4b45A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 110
GLY A  12
GLY A   9
GLY A 106
VAL A 100
 None
None
GSP  A1342 (-3.5A)
GSP  A1342 (-3.9A)
None
 0.98A 2oxtA-4b45A:
2.9		 2oxtA-4b45A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ALA A 112
GLY A 110
GLY A 108
ALA A  11
GLY A  66
 None
None
GSP  A1342 (-4.0A)
GSP  A1342 (-3.3A)
GSP  A1342 (-3.4A)
 0.88A 2pkmA-4b45A:
6.2		 2pkmA-4b45A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 6 VAL A  99
GLY A 191
ARG A 189
LEU A 313
 None
 1.07A 3bjwE-4b45A:
undetectable		 3bjwE-4b45A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ASP A 158
ARG A 189
ILE A 186
ILE A 222
ALA A 157
 None
 1.09A 3ohtA-4b45A:
undetectable
3ohtB-4b45A:
undetectable		 3ohtA-4b45A:
23.56
3ohtB-4b45A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ASP A 158
VAL A 190
ILE A 186
ILE A 222
ALA A 157
 None
 1.23A 3ohtA-4b45A:
undetectable
3ohtB-4b45A:
undetectable		 3ohtA-4b45A:
23.56
3ohtB-4b45A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 9 GLY A 318
GLY A 317
VAL A 314
GLU A 320
ILE A 222
 None
 1.38A 3owxA-4b45A:
6.2		 3owxA-4b45A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		6 / 10 ASP A  33
VAL A   4
GLY A   7
VAL A   8
VAL A 127
ILE A  97
 None
 1.46A 3oxwD-4b45A:
undetectable		 3oxwD-4b45A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ASP A  33
GLY A   7
VAL A   8
VAL A 127
ILE A  97
 None
 0.97A 3oxxC-4b45A:
undetectable		 3oxxC-4b45A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		3 / 3 ILE A 336
VAL A 144
ARG A 148
 None
 0.77A 3p73A-4b45A:
undetectable		 3p73A-4b45A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 108
GLY A  12
LEU A  86
GLN A  79
ALA A 118
 GSP  A1342 (-4.0A)
None
None
None
None
 0.98A 3t7vA-4b45A:
undetectable		 3t7vA-4b45A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 LEU A 162
GLY A 102
GLY A   9
LEU A 133
GLY A 147
 None
GSP  A1342 ( 4.1A)
GSP  A1342 (-3.5A)
None
None
 1.17A 4blvA-4b45A:
undetectable		 4blvA-4b45A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 10 GLY A 106
ALA A  72
GLY A 110
VAL A  64
VAL A   8
 GSP  A1342 (-3.9A)
None
None
GSP  A1342 ( 4.4A)
None
 1.31A 4c5nD-4b45A:
5.4		 4c5nD-4b45A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 6 ARG A 188
GLY A 191
ALA A 271
GLN A  25
 None
 1.04A 4g0uA-4b45A:
2.4		 4g0uA-4b45A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 6 LEU A 315
ALA A 223
LEU A 225
SER A 256
 None
 0.85A 4ikiB-4b45A:
undetectable		 4ikiB-4b45A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 LEU A 115
VAL A  99
GLY A 108
ILE A   6
VAL A  52
 None
None
GSP  A1342 (-4.0A)
None
None
 1.03A 4xdrA-4b45A:
undetectable		 4xdrA-4b45A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 7 LEU A 315
ALA A 223
LEU A 217
ALA A 159
LEU A 193
 None
 1.19A 4z90F-4b45A:
undetectable
4z90G-4b45A:
undetectable
4z90H-4b45A:
undetectable
4z90J-4b45A:
undetectable		 4z90F-4b45A:
22.52
4z90G-4b45A:
22.52
4z90H-4b45A:
22.52
4z90J-4b45A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A   7
GLY A   9
SER A 107
GLY A 108
LEU A   5
 None
GSP  A1342 (-3.5A)
GSP  A1342 (-4.1A)
GSP  A1342 (-4.0A)
None
 1.03A 5c0oH-4b45A:
3.8		 5c0oH-4b45A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 LEU A   5
PHE A  98
LEU A 225
LEU A  19
ALA A 195
 None
 1.19A 5ienB-4b45A:
undetectable		 5ienB-4b45A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		6 / 11 ALA A 116
ALA A 118
VAL A 129
GLY A 110
GLY A 111
ALA A 112
 None
 1.49A 5lf7K-4b45A:
undetectable
5lf7L-4b45A:
undetectable		 5lf7K-4b45A:
22.22
5lf7L-4b45A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		6 / 11 ALA A 116
ALA A 118
VAL A 129
GLY A 110
GLY A 111
ALA A 112
 None
 1.49A 5lf7Y-4b45A:
undetectable
5lf7Z-4b45A:
undetectable		 5lf7Y-4b45A:
22.22
5lf7Z-4b45A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 VAL A 289
LEU A 193
LEU A 267
ALA A 266
ARG A 189
 None
 1.20A 5nd7B-4b45A:
31.8		 5nd7B-4b45A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 LEU A   5
VAL A  31
ALA A 195
ALA A  30
GLY A  29
 None
 1.18A 5tzoB-4b45A:
undetectable		 5tzoB-4b45A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_E_D16E402_1
(THYMIDYLATE SYNTHASE)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 6 PHE A  98
LEU A  15
GLY A  12
TYR A 179
 None
None
None
GSP  A1342 (-3.8A)
 0.89A 5x5qE-4b45A:
undetectable		 5x5qE-4b45A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 5 PRO A 134
GLY A 104
TYR A 142
VAL A 144
 GSP  A1342 ( 4.4A)
GSP  A1342 ( 4.6A)
None
None
 1.24A 5x80C-4b45A:
undetectable
5x80D-4b45A:
undetectable		 5x80C-4b45A:
22.51
5x80D-4b45A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 VAL A  49
LEU A 194
ASP A  23
LEU A  19
ALA A  16
 None
 0.94A 6b0iB-4b45A:
29.8		 6b0iB-4b45A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A  63
HIS A  62
VAL A  82
ILE A  54
ASP A  78
 None
 1.46A 6bxnB-4b45A:
2.8		 6bxnB-4b45A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 4b45 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		6 / 12 ALA A 112
THR A 152
GLY A 110
SER A 109
GLY A 105
ASN A 145
 None
None
None
None
GSP  A1342 (-3.4A)
None
 1.44A 6c79A-4b45A:
undetectable		 6c79A-4b45A:
13.86