SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 0.99A 1eizA-4b46A:
4.6		 1eizA-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
PRO A 117
GLY A 115
GLY A 114
LEU A 134
 GDP  A1368 (-3.6A)
None
None
None
None
 1.00A 1ej0A-4b46A:
undetectable		 1ej0A-4b46A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 8 HIS A 122
TYR A 127
LEU A 123
GLU A  85
 None
 1.10A 1i7zA-4b46A:
undetectable		 1i7zA-4b46A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 112
GLY A 106
LEU A 107
GLY A  75
VAL A 103
 GDP  A1368 (-3.5A)
GDP  A1368 (-3.6A)
None
None
None
 1.19A 1jg2A-4b46A:
undetectable		 1jg2A-4b46A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 4 ARG A 270
LEU A 306
ASN A 307
VAL A 340
 None
 1.49A 1lqtA-4b46A:
2.8		 1lqtA-4b46A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 4 ARG A 270
LEU A 306
ASN A 307
VAL A 340
 None
 1.49A 1lqtB-4b46A:
3.5		 1lqtB-4b46A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 4 ARG A 270
LEU A 306
ASN A 307
VAL A 340
 None
 1.49A 1lquA-4b46A:
3.3		 1lquA-4b46A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 4 ARG A 270
LEU A 306
ASN A 307
VAL A 340
 None
 1.49A 1lquB-4b46A:
3.2		 1lquB-4b46A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 7 ILE A   6
PHE A 101
ALA A 120
ILE A 126
 None
 0.91A 1oniB-4b46A:
4.0
1oniC-4b46A:
undetectable		 1oniB-4b46A:
17.17
1oniC-4b46A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 6 LEU A 134
LEU A 165
SER A 229
SER A 347
 None
 0.97A 1tz8C-4b46A:
undetectable
1tz8D-4b46A:
undetectable		 1tz8C-4b46A:
16.58
1tz8D-4b46A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 PHE A 167
GLY A 135
ASN A 169
ILE A 186
VAL A 228
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-4.2A)
None
 1.02A 2hmyB-4b46A:
4.1		 2hmyB-4b46A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 114
GLY A  12
GLY A   9
GLY A 110
VAL A 104
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-3.6A)
None
 1.04A 2oxtA-4b46A:
undetectable		 2oxtA-4b46A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.04A 2zulA-4b46A:
3.5		 2zulA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.02A 3dmfA-4b46A:
3.8		 3dmfA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 106
GLY A 108
ALA A  70
VAL A 104
VAL A  15
 GDP  A1368 (-3.6A)
GDP  A1368 ( 3.8A)
None
None
None
 1.02A 3dmhA-4b46A:
2.6		 3dmhA-4b46A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 6 ARG A  62
GLY A  59
GLU A  77
GLU A  81
 None
 1.02A 3k9fA-4b46A:
undetectable
3k9fB-4b46A:
undetectable
3k9fD-4b46A:
4.6		 3k9fA-4b46A:
24.17
3k9fB-4b46A:
24.17
3k9fD-4b46A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 5 GLY A 108
GLU A 142
GLY A 106
PRO A 138
 GDP  A1368 ( 3.8A)
GDP  A1368 (-2.7A)
GDP  A1368 (-3.6A)
GDP  A1368 (-4.2A)
 0.96A 3onnA-4b46A:
5.1		 3onnA-4b46A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 112
GLY A 106
ASP A  71
VAL A  68
GLY A 115
 GDP  A1368 (-3.5A)
GDP  A1368 (-3.6A)
None
None
None
 1.06A 3sglA-4b46A:
2.4		 3sglA-4b46A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 PHE A   8
GLY A 115
ARG A 354
GLY A  12
SER A 105
 None
 1.27A 3sueD-4b46A:
undetectable		 3sueD-4b46A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 7 ARG A 315
GLY A 314
ILE A 271
ASN A 307
 None
 0.88A 4g0vA-4b46A:
4.5		 4g0vA-4b46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A  75
GLY A 114
GLY A 115
VAL A  68
VAL A  63
 None
 0.98A 4htfA-4b46A:
3.8		 4htfA-4b46A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A  75
GLY A 114
GLY A 115
VAL A  68
VAL A  63
 None
 1.01A 4htfB-4b46A:
3.2		 4htfB-4b46A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 135
GLY A 106
PRO A 138
LEU A 137
LEU A 164
 None
GDP  A1368 (-3.6A)
GDP  A1368 (-4.2A)
None
None
 1.13A 4x61A-4b46A:
undetectable		 4x61A-4b46A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 ALA A  11
GLY A 108
GLY A 106
GLY A 135
ALA A  70
 GDP  A1368 (-3.3A)
GDP  A1368 ( 3.8A)
GDP  A1368 (-3.6A)
None
None
 1.00A 5c0oG-4b46A:
3.0		 5c0oG-4b46A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 5 ILE A 271
GLY A 342
ILE A 311
LEU A 274
 None
 0.92A 5dzkd-4b46A:
undetectable
5dzkk-4b46A:
undetectable
5dzky-4b46A:
undetectable		 5dzkd-4b46A:
20.00
5dzkk-4b46A:
21.58
5dzky-4b46A:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 LEU A  74
GLY A  69
VAL A  63
SER A 105
GLY A  13
 None
 1.34A 5f9zA-4b46A:
undetectable		 5f9zA-4b46A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		3 / 3 THR A 147
PRO A 138
ASP A 168
 None
GDP  A1368 (-4.2A)
None
 0.59A 5l8dB-4b46A:
undetectable		 5l8dB-4b46A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		3 / 3 THR A 147
PRO A 138
ASP A 168
 None
GDP  A1368 (-4.2A)
None
 0.59A 5mwuB-4b46A:
undetectable		 5mwuB-4b46A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 LEU A 197
LEU A 296
ALA A 295
SER A 324
ARG A 193
 None
 1.18A 5nd7B-4b46A:
31.5		 5nd7B-4b46A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 GLY A 232
VAL A 104
LEU A 102
VAL A  15
ILE A 190
 None
 1.04A 5vopA-4b46A:
undetectable		 5vopA-4b46A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 10 PHE A  19
GLY A  29
ILE A 219
LEU A   3
PHE A 154
 None
 1.36A 5zjiA-4b46A:
undetectable
5zjiJ-4b46A:
undetectable		 5zjiA-4b46A:
11.38
5zjiJ-4b46A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		4 / 5 TYR A 183
GLN A 180
GLY A 112
ILE A 136
 GDP  A1368 (-3.5A)
None
GDP  A1368 (-3.5A)
GDP  A1368 ( 4.2A)
 1.22A 6debB-4b46A:
2.1		 6debB-4b46A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 12 PHE A 167
GLY A 135
ASN A 169
ILE A 186
VAL A 228
 None
None
GDP  A1368 (-3.3A)
GDP  A1368 (-4.2A)
None
 1.10A 6mhtA-4b46A:
3.2		 6mhtA-4b46A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4b46 CELL DIVISION
PROTEIN FTSZ
(Haloferax
volcanii) 		5 / 10 THR A 111
GLY A  65
GLY A  59
VAL A  68
ASN A  38
 GDP  A1368 (-4.3A)
None
None
None
GDP  A1368 ( 4.2A)
 1.42A 6nqaK-4b46A:
undetectable		 6nqaK-4b46A:
21.78