SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b4c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 TRP A1273
ILE A1288
TRP A1253
LEU A1309
 None
 1.30A 1j96A-4b4cA:
undetectable		 1j96A-4b4cA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A1168
VAL A1172
ALA A1179
CYH A1176
 None
 1.03A 1mz9D-4b4cA:
undetectable		 1mz9D-4b4cA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A1310
LEU A1313
ASP A1258
ALA A1306
 None
 0.95A 2opxA-4b4cA:
undetectable		 2opxA-4b4cA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A1254
ILE A1251
ASP A1252
ASN A1260
LEU A1284
 EDO  A2332 (-3.5A)
None
None
None
None
 1.00A 3cjtO-4b4cA:
undetectable		 3cjtO-4b4cA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A1172
TYR A1138
GLU A1218
ILE A1215
 None
 0.85A 3q5sA-4b4cA:
undetectable		 3q5sA-4b4cA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN A1174
CYH A1176
GLY A1175
ILE A1135
 None
 1.04A 3w9tF-4b4cA:
undetectable		 3w9tF-4b4cA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TRP A1273
ILE A1288
TRP A1253
LEU A1309
 None
 1.17A 4xo7B-4b4cA:
undetectable		 4xo7B-4b4cA:
21.45