SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b4d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 5 PRO A 179
VAL A 148
TYR A 177
GLU A 158
 None
 1.18A 1m8dA-4b4dA:
undetectable		 1m8dA-4b4dA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 5 PRO A 179
VAL A 148
TYR A 177
GLU A 158
 None
 1.16A 1m8dB-4b4dA:
undetectable		 1m8dB-4b4dA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 5 PRO A 179
VAL A 148
TYR A 177
GLU A 158
 None
 1.20A 1m9jB-4b4dA:
undetectable		 1m9jB-4b4dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 LEU A 205
ILE A 140
LEU A 192
THR A 193
LEU A 195
 None
None
None
CL  A1261 (-4.0A)
None
 0.73A 2bdmA-4b4dA:
undetectable		 2bdmA-4b4dA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 PRO A  96
GLY A  36
LEU A 100
LEU A  65
SER A  58
 None
 1.26A 2nv4B-4b4dA:
3.7		 2nv4B-4b4dA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 8 LEU A 226
PRO A 122
SER A  55
GLY A 117
 None
None
FAD  A1260 (-3.8A)
None
 1.09A 2qd5A-4b4dA:
2.4		 2qd5A-4b4dA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 ASP A 211
ALA A 213
GLY A 248
THR A 246
TYR A 250
 None
 1.08A 5hfjA-4b4dA:
2.9		 5hfjA-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 ALA A 213
GLY A 248
SER A 241
THR A 246
TYR A 250
 None
 1.21A 5hfjB-4b4dA:
undetectable		 5hfjB-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 ASP A 211
ALA A 213
GLY A 248
THR A 246
TYR A 250
 None
 1.13A 5hfjC-4b4dA:
2.8		 5hfjC-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 ASP A 211
ALA A 213
SER A 241
THR A 246
TYR A 250
 None
 1.20A 5hfjD-4b4dA:
3.2		 5hfjD-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		6 / 12 ASP A 211
ALA A 213
GLY A 248
SER A 241
THR A 246
TYR A 250
 None
 1.24A 5hfjE-4b4dA:
2.8		 5hfjE-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 ASP A 211
ALA A 213
GLY A 248
THR A 246
TYR A 250
 None
 1.11A 5hfjH-4b4dA:
2.5		 5hfjH-4b4dA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_A_ASCA502_0
(OS09G0567300 PROTEIN)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 5 GLU A 158
PRO A 179
ARG A 154
PHE A 186
 None
 1.22A 5jcnA-4b4dA:
1.9		 5jcnA-4b4dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 6 GLU A 158
PRO A 179
ARG A 154
PHE A 186
 None
 1.20A 5jcnB-4b4dA:
2.3		 5jcnB-4b4dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		6 / 9 SER A  55
THR A 118
GLY A 119
ALA A 121
CYH A 220
GLU A 253
 FAD  A1260 (-3.8A)
FAD  A1260 (-3.3A)
None
FAD  A1260 ( 3.8A)
None
FAD  A1260 ( 4.2A)
 0.48A 5vw4A-4b4dA:
7.3		 5vw4A-4b4dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		6 / 9 THR A 118
GLY A 119
ALA A 121
CYH A 220
GLY A 221
GLU A 253
 FAD  A1260 (-3.3A)
None
FAD  A1260 ( 3.8A)
None
None
FAD  A1260 ( 4.2A)
 0.64A 5vw4A-4b4dA:
7.3		 5vw4A-4b4dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 8 SER A  55
THR A 118
GLY A 119
CYH A 220
GLU A 253
 FAD  A1260 (-3.8A)
FAD  A1260 (-3.3A)
None
None
FAD  A1260 ( 4.2A)
 0.49A 5vw5A-4b4dA:
20.9		 5vw5A-4b4dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 8 THR A 118
GLY A 119
CYH A 220
GLY A 221
GLU A 253
 FAD  A1260 (-3.3A)
None
None
None
FAD  A1260 ( 4.2A)
 0.66A 5vw5A-4b4dA:
20.9		 5vw5A-4b4dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		5 / 12 LEU A 151
GLY A 117
ALA A 152
PHE A 256
THR A 116
 None
None
None
FAD  A1260 (-3.7A)
None
 1.34A 5x6yC-4b4dA:
undetectable		 5x6yC-4b4dA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 7 LEU A 100
GLN A  37
PHE A  38
PHE A 252
 None
None
FAD  A1260 ( 3.6A)
None
 0.95A 5zcqP-4b4dA:
undetectable
5zcqW-4b4dA:
undetectable		 5zcqP-4b4dA:
20.59
5zcqW-4b4dA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4d FERREDOXIN-NADP
REDUCTASE
(Xanthomonas
citri) 		4 / 5 LEU A 100
GLN A  37
PHE A  38
PHE A 252
 None
None
FAD  A1260 ( 3.6A)
None
 1.15A 6nmpP-4b4dA:
undetectable
6nmpW-4b4dA:
undetectable		 6nmpP-4b4dA:
20.59
6nmpW-4b4dA:
14.54