SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.93A 1v55A-4b4oA:
undetectable
1v55J-4b4oA:
undetectable		 1v55A-4b4oA:
22.69
1v55J-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 6 ILE A 195
ALA A 199
THR A 203
ALA A  22
 None
 0.85A 1w0gA-4b4oA:
undetectable		 1w0gA-4b4oA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 9 TYR A 112
VAL A 218
GLY A 217
ASP A 121
ILE A 268
 None
 1.34A 2a1oB-4b4oA:
undetectable		 2a1oB-4b4oA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 6 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.92A 2einN-4b4oA:
undetectable
2einW-4b4oA:
undetectable		 2einN-4b4oA:
22.69
2einW-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.94A 3ag3A-4b4oA:
undetectable
3ag3J-4b4oA:
undetectable		 3ag3A-4b4oA:
22.69
3ag3J-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 ALA A  55
GLY A   6
LEU A  89
ALA A 102
TRP A 103
 None
 1.24A 3ou6C-4b4oA:
2.3		 3ou6C-4b4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 ALA A  55
GLY A   6
LEU A  89
ALA A 102
TRP A 103
 None
 1.23A 3ou7C-4b4oA:
2.2		 3ou7C-4b4oA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 6 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.95A 3wg7N-4b4oA:
undetectable
3wg7W-4b4oA:
undetectable		 3wg7N-4b4oA:
22.69
3wg7W-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 GLN A 265
GLY A 108
GLY A 158
VAL A 136
ASN A 216
 None
NDP  A 999 ( 4.4A)
None
None
None
 0.98A 4gc9A-4b4oA:
undetectable		 4gc9A-4b4oA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 8 HIS A 194
ASP A 197
ALA A 199
SER A 280
 None
 1.04A 4k0bB-4b4oA:
undetectable		 4k0bB-4b4oA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 8 HIS A 194
ASP A 197
ALA A 199
SER A 280
 None
 1.01A 4l7iB-4b4oA:
undetectable		 4l7iB-4b4oA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 PHE A 281
ALA A 292
ALA A 234
GLY A 233
LEU A 236
 None
 1.09A 4oaeA-4b4oA:
undetectable		 4oaeA-4b4oA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_A_AZMA299_1
(CARBONATE
DEHYDRATASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.21A 4uovA-4b4oA:
undetectable		 4uovA-4b4oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.21A 4uovC-4b4oA:
undetectable		 4uovC-4b4oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_D_AZMD299_1
(CARBONATE
DEHYDRATASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.21A 4uovD-4b4oA:
undetectable		 4uovD-4b4oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_E_AZME299_1
(CARBONATE
DEHYDRATASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.21A 4uovE-4b4oA:
undetectable		 4uovE-4b4oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_F_AZMF299_1
(CARBONATE
DEHYDRATASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.21A 4uovF-4b4oA:
undetectable		 4uovF-4b4oA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 10 GLY A   6
VAL A   5
VAL A  56
LEU A  49
LEU A 206
 None
 1.27A 4yb6B-4b4oA:
undetectable
4yb6C-4b4oA:
undetectable		 4yb6B-4b4oA:
24.22
4yb6C-4b4oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 10 GLY A   6
VAL A   5
VAL A  56
LEU A  49
LEU A 206
 None
 1.18A 4yb6C-4b4oA:
undetectable
4yb6F-4b4oA:
undetectable		 4yb6C-4b4oA:
24.22
4yb6F-4b4oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 10 LEU A  49
LEU A 206
GLY A   6
VAL A   5
VAL A  56
 None
 1.19A 4yb6A-4b4oA:
undetectable
4yb6D-4b4oA:
undetectable		 4yb6A-4b4oA:
24.22
4yb6D-4b4oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 10 LEU A  49
LEU A 206
GLY A   6
VAL A   5
VAL A  56
 None
 1.19A 4yb6D-4b4oA:
undetectable
4yb6E-4b4oA:
undetectable		 4yb6D-4b4oA:
24.22
4yb6E-4b4oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 GLY A 186
LEU A 161
ILE A  12
GLY A 217
THR A 224
 None
None
NDP  A 999 (-3.8A)
None
None
 1.08A 4ze2A-4b4oA:
undetectable		 4ze2A-4b4oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.91A 5b1aA-4b4oA:
undetectable
5b1aJ-4b4oA:
undetectable		 5b1aA-4b4oA:
22.69
5b1aJ-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.92A 5b3sA-4b4oA:
undetectable
5b3sJ-4b4oA:
undetectable		 5b3sA-4b4oA:
22.69
5b3sJ-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.92A 5b3sN-4b4oA:
undetectable
5b3sW-4b4oA:
undetectable		 5b3sN-4b4oA:
22.69
5b3sW-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 GLY A 186
LEU A 161
ILE A  12
GLY A 217
THR A 224
 None
None
NDP  A 999 (-3.8A)
None
None
 1.19A 5eskA-4b4oA:
undetectable		 5eskA-4b4oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.25A 5jn8B-4b4oA:
undetectable		 5jn8B-4b4oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 11 GLU A 207
HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 1.25A 5jncA-4b4oA:
undetectable		 5jncA-4b4oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		5 / 12 VAL A  56
LEU A 206
TRP A  41
GLY A   8
LEU A  16
 None
 1.09A 5jvzA-4b4oA:
undetectable		 5jvzA-4b4oA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 8 HIS A  25
VAL A  27
VAL A   3
THR A 203
 None
 0.78A 5tt3F-4b4oA:
undetectable		 5tt3F-4b4oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.91A 5xdqN-4b4oA:
undetectable
5xdqW-4b4oA:
undetectable		 5xdqN-4b4oA:
22.69
5xdqW-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.93A 5xdxA-4b4oA:
undetectable
5xdxJ-4b4oA:
undetectable		 5xdxA-4b4oA:
22.69
5xdxJ-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 6 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.93A 5z86N-4b4oA:
undetectable
5z86W-4b4oA:
undetectable		 5z86N-4b4oA:
22.69
5z86W-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 6 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.94A 5zcoN-4b4oA:
undetectable
5zcoW-4b4oA:
undetectable		 5zcoN-4b4oA:
22.69
5zcoW-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.92A 5zcpA-4b4oA:
undetectable
5zcpJ-4b4oA:
undetectable		 5zcpA-4b4oA:
22.69
5zcpJ-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 ILE A 193
TYR A 277
THR A 203
LEU A 202
 None
 0.92A 5zcqA-4b4oA:
undetectable
5zcqJ-4b4oA:
undetectable		 5zcqA-4b4oA:
22.69
5zcqJ-4b4oA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4b4o EPIMERASE FAMILY
PROTEIN SDR39U1
(Homo
sapiens) 		4 / 7 TYR A 277
LEU A 215
TYR A 279
VAL A 155
 None
 1.18A 6g2pA-4b4oA:
2.3		 6g2pA-4b4oA:
24.00