SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 4b4s BCL-2-LIKE PROTEIN
10
(Homo
sapiens) 		4 / 6 LEU A 130
LEU A  16
SER A  19
THR A  95
 None
 1.06A 1ictB-4b4sA:
undetectable		 1ictB-4b4sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4b4s BCL-2-LIKE PROTEIN
10
(Homo
sapiens) 		4 / 6 LEU A 130
LEU A  16
SER A  19
THR A  95
 None
 1.03A 1tyrA-4b4sA:
undetectable		 1tyrA-4b4sA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4b4s BCL-2-LIKE PROTEIN
10
(Homo
sapiens) 		4 / 7 LEU A 146
VAL A 131
LEU A 134
SER A 135
 None
 0.53A 3r9vA-4b4sA:
undetectable
3r9vB-4b4sA:
undetectable		 3r9vA-4b4sA:
21.43
3r9vB-4b4sA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b4s BCL-2-LIKE PROTEIN
10
(Homo
sapiens) 		4 / 8 THR A  91
THR A  82
LEU A  45
VAL A  74
 None
 1.00A 4l4aA-4b4sA:
undetectable		 4l4aA-4b4sA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4b4s BCL-2-LIKE PROTEIN
10
(Homo
sapiens) 		4 / 6 LEU A 130
LEU A  16
SER A  19
THR A  95
 None
 1.23A 5l4iB-4b4sA:
undetectable		 5l4iB-4b4sA:
20.11