SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GYX_A_BEZA1077_0
(HYPOTHETICAL PROTEIN
YDCE)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 7 CYH A 124
PHE A 127
ARG A 107
SER A 139
 None
None
EDO  A1287 (-4.0A)
None
 1.46A 1gyxA-4b4uA:
1.4
1gyxB-4b4uA:
1.0		 1gyxA-4b4uA:
14.19
1gyxB-4b4uA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 4 THR A  29
LEU A  25
VAL A  22
LEU A  18
 None
 0.98A 1mz9D-4b4uA:
undetectable		 1mz9D-4b4uA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		3 / 3 THR A 265
PRO A 263
THR A 267
 None
EDO  A1286 (-4.3A)
None
 0.70A 209dC-4b4uA:
undetectable		 209dC-4b4uA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 9 THR A 268
GLY A 144
THR A 141
ALA A 140
LEU A 269
 None
 1.16A 2npnA-4b4uA:
2.0		 2npnA-4b4uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 8 THR A 255
PRO A 256
VAL A 257
ALA A 229
 None
None
EDO  A1286 ( 4.9A)
None
 1.05A 2v41G-4b4uA:
undetectable
2v41H-4b4uA:
undetectable		 2v41G-4b4uA:
20.57
2v41H-4b4uA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 9 VAL A 257
GLY A 259
PRO A 263
THR A 265
GLY A 144
 EDO  A1286 ( 4.9A)
EDO  A1286 (-3.7A)
EDO  A1286 (-4.3A)
None
None
 1.20A 3bjwG-4b4uA:
1.9		 3bjwG-4b4uA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 5 PRO A 258
VAL A 257
THR A 147
GLY A 144
 EDO  A1286 (-4.0A)
EDO  A1286 ( 4.9A)
None
None
 1.17A 3elzB-4b4uA:
undetectable		 3elzB-4b4uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.02A 3ln1A-4b4uA:
undetectable		 3ln1A-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.01A 3ln1B-4b4uA:
undetectable		 3ln1B-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.02A 3ln1C-4b4uA:
undetectable		 3ln1C-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 257
ALA A 253
VAL A 227
GLY A 207
ALA A 229
 EDO  A1286 ( 4.9A)
None
None
None
None
 1.01A 3ln1D-4b4uA:
undetectable		 3ln1D-4b4uA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 10 PRO A 173
SER A 167
GLY A 171
PRO A 142
ASP A 228
 None
NAP  A1001 (-4.5A)
None
None
None
 1.27A 3lsfB-4b4uA:
undetectable
3lsfE-4b4uA:
1.2		 3lsfB-4b4uA:
20.97
3lsfE-4b4uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 VAL A 227
LEU A 149
GLY A 223
ALA A 224
SER A 252
 None
 1.12A 3rr3D-4b4uA:
undetectable		 3rr3D-4b4uA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 LEU A  65
GLY A  93
ALA A 280
PRO A  33
LEU A  25
 None
 1.11A 3tm4A-4b4uA:
4.5		 3tm4A-4b4uA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 ILE A 145
VAL A 163
LEU A 198
ALA A 224
ILE A 215
 None
 1.18A 3w67C-4b4uA:
undetectable		 3w67C-4b4uA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 6 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.93A 4ac9C-4b4uA:
4.0		 4ac9C-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 6 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.96A 4acaC-4b4uA:
undetectable		 4acaC-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 6 THR A 141
GLY A 144
ARG A   8
ILE A 148
 None
None
EDO  A1286 (-3.5A)
None
 0.96A 4acbC-4b4uA:
undetectable		 4acbC-4b4uA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 7 THR A  73
LEU A  79
VAL A 100
VAL A  40
 None
 1.01A 4cp4A-4b4uA:
undetectable		 4cp4A-4b4uA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 5 SER A 167
GLY A 165
THR A 141
VAL A 206
 NAP  A1001 (-4.5A)
NAP  A1001 (-3.6A)
None
None
 1.04A 4eohA-4b4uA:
4.2		 4eohA-4b4uA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 12 GLY A 230
GLY A 210
LEU A 214
ILE A 242
ALA A 229
 None
NAP  A1001 ( 3.9A)
NAP  A1001 (-4.6A)
None
None
 1.10A 4qtuB-4b4uA:
2.6		 4qtuB-4b4uA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		4 / 7 GLU A  15
LYS A  12
ALA A  11
ASN A  55
 None
 0.98A 5mvsA-4b4uA:
4.6		 5mvsA-4b4uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 10 ILE A 148
ILE A 187
ALA A 175
LEU A 178
ALA A 183
 None
 1.47A 5zjiB-4b4uA:
undetectable		 5zjiB-4b4uA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		7 / 12 LEU A  95
GLN A  97
ASP A 120
THR A 141
SER A 167
ILE A 169
THR A 265
 None
None
None
None
NAP  A1001 (-4.5A)
None
None
 1.04A 6debB-4b4uA:
40.9		 6debB-4b4uA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		7 / 12 LEU A  95
GLN A  97
PRO A  99
ASP A 120
THR A 141
ILE A 169
THR A 265
 None
 1.04A 6debB-4b4uA:
40.9		 6debB-4b4uA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 10 SER A  46
LEU A  78
ASP A 120
ILE A 104
PRO A 101
 None
 1.37A 6dlzB-4b4uA:
4.6
6dlzC-4b4uA:
4.7		 6dlzB-4b4uA:
12.87
6dlzC-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 11 ILE A 104
PRO A 101
SER A  46
LEU A  78
ASP A 120
 None
 1.38A 6dlzA-4b4uA:
4.8
6dlzD-4b4uA:
4.6		 6dlzA-4b4uA:
12.87
6dlzD-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 10 SER A  46
LEU A  78
ASP A 120
ILE A 104
PRO A 101
 None
 1.37A 6dm1B-4b4uA:
4.5
6dm1C-4b4uA:
4.8		 6dm1B-4b4uA:
12.87
6dm1C-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 11 ILE A 104
PRO A 101
SER A  46
LEU A  78
ASP A 120
 None
 1.37A 6dm1A-4b4uA:
4.6
6dm1D-4b4uA:
4.6		 6dm1A-4b4uA:
12.87
6dm1D-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 10 SER A  46
LEU A  78
ASP A 120
ILE A 104
PRO A 101
 None
 1.42A 6dm2B-4b4uA:
4.5
6dm2C-4b4uA:
4.6		 6dm2B-4b4uA:
12.87
6dm2C-4b4uA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4b4u BIFUNCTIONAL PROTEIN
FOLD
(Acinetobacter
baumannii) 		5 / 10 ILE A 104
PRO A 101
SER A  46
LEU A  78
ASP A 120
 None
 1.42A 6dm2A-4b4uA:
4.7
6dm2D-4b4uA:
4.6		 6dm2A-4b4uA:
12.87
6dm2D-4b4uA:
12.87