SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 5 THR A 238
ASP A 358
HIS A 362
HIS A 406
HIS A 517
 ZN  A1002 ( 2.3A)
ZN  A1001 (-2.1A)
ZN  A1001 ( 3.2A)
ZN  A1002 (-3.2A)
ZN  A1001 ( 3.3A)
 0.48A 1ei6A-4b56A:
5.1		 1ei6A-4b56A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		6 / 8 ASP A 200
THR A 238
ASP A 358
HIS A 362
HIS A 406
HIS A 517
 ZN  A1002 ( 2.1A)
ZN  A1002 ( 2.3A)
ZN  A1001 (-2.1A)
ZN  A1001 ( 3.2A)
ZN  A1002 (-3.2A)
ZN  A1001 ( 3.3A)
 0.47A 1ei6C-4b56A:
8.3		 1ei6C-4b56A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 THR A 238
ASP A 358
HIS A 362
HIS A 517
 ZN  A1002 ( 2.3A)
ZN  A1001 (-2.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.3A)
 0.45A 1ei6D-4b56A:
15.3		 1ei6D-4b56A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 PHE A 328
ARG A 331
LEU A 389
LEU A 352
LEU A 220
 None
 1.28A 1eiiA-4b56A:
1.0		 1eiiA-4b56A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 5 THR A 608
LEU A 693
GLY A 606
LYS A 711
 None
 1.39A 1gtiF-4b56A:
undetectable		 1gtiF-4b56A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 VAL A 779
ASP A 789
ASP A 783
HIS A 811
 None
CA  A1003 (-3.3A)
CA  A1003 (-2.5A)
None
 1.26A 1pk2A-4b56A:
undetectable		 1pk2A-4b56A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 ASP A 631
TYR A 634
GLU A 628
 None
 0.75A 1vm1A-4b56A:
undetectable		 1vm1A-4b56A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 TRP A 289
THR A 247
TYR A 243
 None
 1.20A 2a3bA-4b56A:
undetectable		 2a3bA-4b56A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 LYS A 510
GLY A 365
PRO A 366
 None
 0.54A 2hreB-4b56A:
undetectable		 2hreB-4b56A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 11 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.87A 2iyfA-4b56A:
undetectable		 2iyfA-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.89A 2iyfB-4b56A:
undetectable		 2iyfB-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 LEU A 195
GLY A 532
ASN A 399
LEU A 398
LEU A 389
 None
 0.99A 2nxeB-4b56A:
undetectable		 2nxeB-4b56A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 LEU A 477
PRO A 478
LEU A 481
 None
 0.50A 2qd5B-4b56A:
undetectable		 2qd5B-4b56A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 11 LEU A 402
ILE A 531
GLY A 532
SER A 198
LEU A 199
 None
 1.00A 2qmmA-4b56A:
undetectable
2qmmB-4b56A:
undetectable		 2qmmA-4b56A:
13.48
2qmmB-4b56A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 ASP A 358
GLN A 410
PHE A 516
GLY A 411
GLY A 407
 ZN  A1001 (-2.1A)
None
None
None
None
 1.45A 2y6rC-4b56A:
undetectable		 2y6rC-4b56A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 LEU A 195
GLY A 532
ASN A 399
LEU A 398
LEU A 389
 None
 1.09A 2zbpA-4b56A:
undetectable		 2zbpA-4b56A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 9 LEU A 402
ILE A 531
GLY A 532
SER A 198
LEU A 199
 None
 1.07A 3ai9X-4b56A:
undetectable		 3ai9X-4b56A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 LEU A 195
GLY A 532
ASN A 399
LEU A 398
LEU A 389
 None
 1.05A 3cjtG-4b56A:
undetectable		 3cjtG-4b56A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 LEU A 195
GLY A 532
LEU A 558
LEU A 398
LEU A 389
 None
 1.12A 3cjtG-4b56A:
undetectable		 3cjtG-4b56A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		6 / 12 LEU A 195
GLY A 532
LEU A 558
ASN A 399
LEU A 398
LEU A 389
 None
 1.31A 3cjtO-4b56A:
undetectable		 3cjtO-4b56A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 GLU A 847
HIS A 841
HIS A 811
 None
 0.94A 3co4A-4b56A:
undetectable		 3co4A-4b56A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 THR A 817
SER A 834
PHE A 813
 None
 0.84A 3d4sA-4b56A:
undetectable		 3d4sA-4b56A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 5 TYR A 422
ALA A 437
ALA A 457
TYR A 453
 None
 1.22A 3d91A-4b56A:
undetectable		 3d91A-4b56A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		6 / 12 GLY A 248
ASN A 567
ILE A 288
ASN A 548
LEU A 249
THR A 351
 None
NAG  A2001 (-1.9A)
None
None
NAG  A2001 (-4.9A)
None
 1.47A 3eeyC-4b56A:
undetectable		 3eeyC-4b56A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		6 / 12 GLY A 248
ASN A 567
ILE A 288
ASN A 548
LEU A 249
THR A 351
 None
NAG  A2001 (-1.9A)
None
None
NAG  A2001 (-4.9A)
None
 1.48A 3eeyE-4b56A:
undetectable		 3eeyE-4b56A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 5 VAL A 815
ILE A 838
TYR A 747
MET A 746
 None
 1.27A 3gvuA-4b56A:
undetectable		 3gvuA-4b56A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 5 PRO A 700
SER A 702
LEU A 655
SER A 741
 None
 1.35A 3ijxH-4b56A:
undetectable		 3ijxH-4b56A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 7 THR A 238
ASP A 358
HIS A 362
HIS A 517
 ZN  A1002 ( 2.3A)
ZN  A1001 (-2.1A)
ZN  A1001 ( 3.2A)
ZN  A1001 ( 3.3A)
 0.44A 3t01A-4b56A:
26.6		 3t01A-4b56A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 LEU A 477
PRO A 478
LEU A 481
 None
 0.46A 3w1wB-4b56A:
undetectable		 3w1wB-4b56A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 SER A 690
ASN A 691
GLY A 719
GLN A 751
 None
 0.92A 4af0A-4b56A:
undetectable		 4af0A-4b56A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 ILE A 256
ARG A 488
PRO A 316
VAL A 309
 None
 1.10A 4f4dB-4b56A:
undetectable		 4f4dB-4b56A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 HIS A 811
GLY A 786
ILE A 876
 None
NAG  A2001 ( 4.9A)
None
 0.54A 4k50A-4b56A:
undetectable		 4k50A-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 HIS A 811
GLY A 786
ILE A 876
 None
NAG  A2001 ( 4.9A)
None
 0.56A 4k50I-4b56A:
undetectable		 4k50I-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 HIS A 155
ASP A 157
SER A 142
ASP A 151
 None
 1.16A 4kttA-4b56A:
undetectable		 4kttA-4b56A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 11 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.87A 4m83A-4b56A:
undetectable		 4m83A-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_B_ERYB501_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 11 ASN A 293
VAL A 290
ILE A 562
TYR A 552
ALA A 564
 None
 0.91A 4m83B-4b56A:
undetectable		 4m83B-4b56A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 7 PRO A 240
SER A 274
PHE A 270
ASP A 258
 None
 1.31A 4ndnC-4b56A:
undetectable		 4ndnC-4b56A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 ASP A 872
LYS A 896
LEU A 893
 None
 1.02A 4ptjA-4b56A:
undetectable		 4ptjA-4b56A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 TYR A 433
GLY A 518
ASP A 405
ASP A 200
GLY A 201
 None
None
ZN  A1002 (-2.3A)
ZN  A1002 ( 2.1A)
None
 1.13A 4qa0A-4b56A:
undetectable		 4qa0A-4b56A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 TYR A 433
GLY A 518
ASP A 405
ASP A 200
GLY A 201
 None
None
ZN  A1002 (-2.3A)
ZN  A1002 ( 2.1A)
None
 1.20A 4qa2A-4b56A:
undetectable		 4qa2A-4b56A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 TYR A 433
GLY A 518
ASP A 405
ASP A 200
GLY A 201
 None
None
ZN  A1002 (-2.3A)
ZN  A1002 ( 2.1A)
None
 1.20A 4qa2B-4b56A:
undetectable		 4qa2B-4b56A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 10 ASP A 200
TYR A 322
TYR A 353
PHE A 328
SER A 198
 ZN  A1002 ( 2.1A)
None
None
None
None
 1.47A 4xpbA-4b56A:
undetectable		 4xpbA-4b56A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 5 MET A 233
GLU A 547
TYR A 250
ARG A 869
 None
 1.21A 4yshB-4b56A:
undetectable		 4yshB-4b56A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		6 / 11 LEU A 398
LEU A 339
LEU A 354
LEU A 402
LEU A 400
LEU A 199
 None
 1.35A 4zowA-4b56A:
undetectable		 4zowA-4b56A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 7 PRO A 240
SER A 274
PHE A 270
ASP A 258
 None
 1.26A 5a1iA-4b56A:
undetectable		 5a1iA-4b56A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 6 GLU A 550
GLY A 201
ASP A 200
GLY A 407
 None
None
ZN  A1002 ( 2.1A)
None
 0.90A 5cdnC-4b56A:
3.0
5cdnD-4b56A:
undetectable		 5cdnC-4b56A:
19.40
5cdnD-4b56A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 6 GLU A 550
GLY A 201
ASP A 200
GLY A 407
 None
None
ZN  A1002 ( 2.1A)
None
 0.91A 5cdnT-4b56A:
2.9
5cdnU-4b56A:
undetectable		 5cdnT-4b56A:
19.40
5cdnU-4b56A:
12.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 ASP A 200
THR A 238
PHE A 239
PRO A 287
ARG A 331
 ZN  A1002 ( 2.1A)
ZN  A1002 ( 2.3A)
None
None
None
 0.95A 5dlvA-4b56A:
53.4		 5dlvA-4b56A:
44.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		6 / 12 ASP A 200
THR A 238
PHE A 239
PRO A 287
TRP A 289
ARG A 331
 ZN  A1002 ( 2.1A)
ZN  A1002 ( 2.3A)
None
None
None
None
 0.95A 5dlvB-4b56A:
53.6		 5dlvB-4b56A:
44.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 10 GLY A 365
GLY A 361
SER A 360
LEU A 375
GLU A 356
 None
 1.19A 5hwkA-4b56A:
undetectable		 5hwkA-4b56A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 10 GLY A 365
GLY A 361
SER A 360
LEU A 375
GLU A 356
 None
 1.19A 5hwkB-4b56A:
undetectable		 5hwkB-4b56A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 10 LEU A 354
ILE A 217
LEU A 220
LEU A 389
LEU A 195
 None
 1.25A 5y7pB-4b56A:
undetectable		 5y7pB-4b56A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 10 LEU A 354
ILE A 217
LEU A 220
LEU A 389
LEU A 195
 None
 1.23A 5y7pD-4b56A:
undetectable		 5y7pD-4b56A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 10 LEU A 354
ILE A 217
LEU A 220
LEU A 389
LEU A 195
 None
 1.24A 5y7pH-4b56A:
undetectable		 5y7pH-4b56A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 5 ALA A 374
SER A 360
GLY A 361
TYR A 206
 None
 1.24A 5yodB-4b56A:
undetectable		 5yodB-4b56A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		3 / 3 TYR A 710
HIS A 705
MET A 670
 None
 1.06A 6af6A-4b56A:
undetectable		 6af6A-4b56A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 VAL A 551
PHE A 537
LEU A 385
VAL A 382
GLY A 534
 None
 1.16A 6brdA-4b56A:
undetectable		 6brdA-4b56A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		5 / 12 ASP A 358
HIS A 242
GLY A 518
HIS A 517
MET A 408
 ZN  A1001 (-2.1A)
None
None
ZN  A1001 ( 3.3A)
ZN  A1001 ( 4.9A)
 1.46A 6exiD-4b56A:
undetectable		 6exiD-4b56A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 HIS A 155
ASP A 157
SER A 142
ASP A 151
 None
 1.19A 6fbnB-4b56A:
undetectable		 6fbnB-4b56A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 8 HIS A 155
ASP A 157
SER A 142
ASP A 151
 None
 1.15A 6fcbA-4b56A:
undetectable		 6fcbA-4b56A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1
(Mus
musculus) 		4 / 7 PRO A 240
SER A 274
PHE A 270
ASP A 258
 None
 1.28A 6g6rA-4b56A:
undetectable		 6g6rA-4b56A:
18.40