SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b5d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		6 / 12 ILE A  87
VAL A 119
LEU A  74
VAL A 125
THR A  96
TRP A  69
 None
 1.32A 2aw1A-4b5dA:
undetectable		 2aw1A-4b5dA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WNC_A_TKTA300_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		5 / 10 TRP A 153
TYR A 194
CSS A 196
CSS A 197
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 ( 3.8A)
SW4  A1213 ( 4.2A)
SW4  A1213 (-3.6A)
SW4  A1213 (-3.7A)
 0.72A 2wncA-4b5dA:
21.7
2wncE-4b5dA:
17.6		 2wncA-4b5dA:
28.11
2wncE-4b5dA:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 7 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.48A 2xz5B-4b5dA:
22.2
2xz5E-4b5dA:
22.1		 2xz5B-4b5dA:
29.88
2xz5E-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.51A 2xz5A-4b5dA:
22.1
2xz5C-4b5dA:
22.2		 2xz5A-4b5dA:
29.88
2xz5C-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.50A 2xz5C-4b5dA:
22.2
2xz5D-4b5dA:
22.1		 2xz5C-4b5dA:
29.88
2xz5D-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 7 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.49A 2xz5D-4b5dA:
22.1
2xz5E-4b5dA:
22.1		 2xz5D-4b5dA:
29.88
2xz5E-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 MET A   5
ALA A   6
LEU A   9
GLN A  85
 None
 0.48A 3cldB-4b5dA:
undetectable		 3cldB-4b5dA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.44A 4afgD-4b5dA:
33.8
4afgE-4b5dA:
34.4		 4afgD-4b5dA:
100.00
4afgE-4b5dA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.36A 4aftD-4b5dA:
21.9
4aftE-4b5dA:
17.6		 4aftD-4b5dA:
29.88
4aftE-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 TRP A 153
VAL A 154
TYR A 194
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 (-4.5A)
SW4  A1213 ( 3.8A)
SW4  A1213 (-3.7A)
 0.36A 4bqtC-4b5dA:
21.9
4bqtD-4b5dA:
21.9		 4bqtC-4b5dA:
29.88
4bqtD-4b5dA:
29.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		3 / 3 LEU A 101
MET A 109
ASP A 144
 None
 0.70A 4j7xB-4b5dA:
undetectable		 4j7xB-4b5dA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 6 LEU A  42
LEU A 173
ASN A 185
ILE A 182
 None
 0.93A 4ww7A-4b5dA:
1.3		 4ww7A-4b5dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 8 LEU A 172
LEU A  42
ALA A  63
LEU A 133
 None
 0.82A 5y7pE-4b5dA:
undetectable		 5y7pE-4b5dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4b5d CAPITELLA TELETA
ACHBP
(Capitella
teleta) 		4 / 7 TRP A 153
CSS A 196
CSS A 197
TYR A 201
 SW4  A1213 (-4.0A)
SW4  A1213 ( 4.2A)
SW4  A1213 (-3.6A)
SW4  A1213 (-3.7A)
 0.74A 6cnkB-4b5dA:
17.6
6cnkC-4b5dA:
21.2		 6cnkB-4b5dA:
13.59
6cnkC-4b5dA:
19.26