SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 LEU A   2
VAL A 225
VAL A 252
LEU A 103
TYR A 256
 None
 1.33A 1lwfA-4b5mA:
undetectable		 1lwfA-4b5mA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 5 LYS A 240
ALA A 248
LEU A 250
SER A   6
 None
 0.95A 1tt6B-4b5mA:
undetectable		 1tt6B-4b5mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		3 / 3 ARG A 193
ASN A 151
THR A 203
 None
 0.82A 2q63A-4b5mA:
undetectable		 2q63A-4b5mA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 5 ILE A 183
HIS A 184
TYR A 222
ARG A 193
 None
 1.26A 3b9mA-4b5mA:
undetectable		 3b9mA-4b5mA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 6 LYS A 240
ALA A 248
LEU A 250
SER A   6
 None
 0.95A 3d2tB-4b5mA:
undetectable		 3d2tB-4b5mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 10 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fhjA-4b5mA:
undetectable		 3fhjA-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 10 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fhjB-4b5mA:
undetectable		 3fhjB-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 10 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.20A 3fhjC-4b5mA:
undetectable		 3fhjC-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fhjD-4b5mA:
undetectable		 3fhjD-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 10 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fhjE-4b5mA:
undetectable		 3fhjE-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fhjF-4b5mA:
undetectable		 3fhjF-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fi0A-4b5mA:
undetectable		 3fi0A-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.16A 3fi0C-4b5mA:
undetectable		 3fi0C-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.19A 3fi0D-4b5mA:
undetectable		 3fi0D-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.23A 3fi0F-4b5mA:
undetectable		 3fi0F-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.09A 3fi0H-4b5mA:
undetectable		 3fi0H-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.12A 3fi0J-4b5mA:
undetectable		 3fi0J-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.17A 3fi0K-4b5mA:
undetectable		 3fi0K-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.17A 3fi0L-4b5mA:
undetectable		 3fi0L-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.18A 3fi0M-4b5mA:
undetectable		 3fi0M-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.15A 3fi0N-4b5mA:
undetectable		 3fi0N-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.15A 3fi0O-4b5mA:
undetectable		 3fi0O-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 9 ASP A  30
ILE A  31
VAL A 105
VAL A 145
GLN A 223
 None
 1.21A 3fi0R-4b5mA:
undetectable		 3fi0R-4b5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 6 LYS A 185
LEU A 186
LEU A 134
GLU A 135
 None
 1.11A 3h5gB-4b5mA:
undetectable
3h5gC-4b5mA:
undetectable		 3h5gB-4b5mA:
6.56
3h5gC-4b5mA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 6 VAL A 182
ILE A 152
HIS A 154
ILE A 183
 None
 0.59A 3hegA-4b5mA:
undetectable		 3hegA-4b5mA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		3 / 3 ASP A 149
TYR A 109
TRP A 204
 None
 1.37A 4p7nA-4b5mA:
undetectable		 4p7nA-4b5mA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 12 ASP A  47
TYR A  16
SER A  45
ALA A  39
TYR A  72
 None
 1.45A 4u15B-4b5mA:
undetectable		 4u15B-4b5mA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 8 ARG A 142
ASP A  99
PHE A 100
VAL A 145
 None
 1.10A 4xqgA-4b5mA:
undetectable		 4xqgA-4b5mA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 8 ARG A 142
ASP A  99
PHE A 100
VAL A 145
 None
 1.12A 4xqgB-4b5mA:
undetectable		 4xqgB-4b5mA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 7 ARG A 219
ARG A 176
ILE A 179
TYR A 222
 None
 1.20A 5a06B-4b5mA:
undetectable		 5a06B-4b5mA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 6 LYS A 240
ALA A 248
LEU A 250
SER A   6
 None
 0.96A 5bojA-4b5mA:
undetectable		 5bojA-4b5mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		5 / 12 ASP A  90
ALA A  70
PHE A 130
GLY A  68
LEU A  37
 None
 0.96A 5i73A-4b5mA:
undetectable		 5i73A-4b5mA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4b5m PUTATIVE
EXODEOXYRIBONUCLEASE
(Neisseria
meningitidis) 		4 / 8 SER A  45
ASP A  47
PRO A  51
TYR A  72
 None
 0.92A 5l1fA-4b5mA:
undetectable
5l1fB-4b5mA:
undetectable		 5l1fA-4b5mA:
14.84
5l1fB-4b5mA:
14.84