SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b5q'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		3 / 3 VAL A  21
VAL A  19
TRP A  18
 None
 0.95A 1av2C-4b5qA:
undetectable
1av2D-4b5qA:
undetectable		 1av2C-4b5qA:
5.26
1av2D-4b5qA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		5 / 12 THR A  15
ALA A  52
THR A  51
ALA A  91
ALA A 164
 None
 0.94A 2gluB-4b5qA:
undetectable		 2gluB-4b5qA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		3 / 3 VAL A  19
TRP A  18
VAL A  21
 None
 0.90A 2izqA-4b5qA:
undetectable
2izqB-4b5qA:
undetectable		 2izqA-4b5qA:
5.26
2izqB-4b5qA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		4 / 7 VAL A  36
THR A  37
PHE A  41
ARG A  42
 None
 0.84A 2kotA-4b5qA:
undetectable		 2kotA-4b5qA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		3 / 3 VAL A  21
VAL A  19
TRP A  18
 None
 0.87A 3l8lA-4b5qA:
undetectable
3l8lB-4b5qA:
undetectable		 3l8lA-4b5qA:
5.26
3l8lB-4b5qA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		4 / 7 TYR A 198
LEU A 200
LEU A 117
THR A 121
 None
 1.06A 3lm8B-4b5qA:
undetectable
3lm8D-4b5qA:
undetectable		 3lm8B-4b5qA:
21.31
3lm8D-4b5qA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		5 / 10 VAL A  60
PHE A   7
LEU A 166
VAL A 168
THR A 129
 None
 1.06A 4e3hA-4b5qA:
undetectable		 4e3hA-4b5qA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		4 / 5 HIS A   1
HIS A  76
GLN A 158
TYR A 160
 CU  A 221 ( 3.0A)
CU  A 221 ( 3.1A)
GOL  A 222 (-3.0A)
CU  A 221 (-4.9A)
 0.75A 4gboA-4b5qA:
8.3		 4gboA-4b5qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		4 / 5 HIS A   1
HIS A 149
GLN A 158
TYR A 160
 CU  A 221 ( 3.0A)
GOL  A 222 (-4.2A)
GOL  A 222 (-3.0A)
CU  A 221 (-4.9A)
 0.90A 4gboB-4b5qA:
8.4		 4gboB-4b5qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		5 / 12 GLU A 144
ILE A 193
LEU A  48
LYS A 104
ILE A 161
 None
 0.98A 4o1eB-4b5qA:
undetectable		 4o1eB-4b5qA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		3 / 3 PRO A  10
LEU A 141
SER A  61
 None
 0.81A 5fsaB-4b5qA:
undetectable		 5fsaB-4b5qA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		4 / 5 HIS A   1
HIS A  76
GLN A 158
TYR A 160
 CU  A 221 ( 3.0A)
CU  A 221 ( 3.1A)
GOL  A 222 (-3.0A)
CU  A 221 (-4.9A)
 0.73A 5uizA-4b5qA:
8.4		 5uizA-4b5qA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 4b5q GLYCOSIDE HYDROLASE
FAMILY 61 PROTEIN D
(Phanerochaete
chrysosporium) 		4 / 4 HIS A   1
HIS A 149
GLN A 158
TYR A 160
 CU  A 221 ( 3.0A)
GOL  A 222 (-4.2A)
GOL  A 222 (-3.0A)
CU  A 221 (-4.9A)
 0.90A 5uizB-4b5qA:
8.4		 5uizB-4b5qA:
20.24