SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b61'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 431
GLU A 368
PHE A 356
ARG A 365
 None
 1.39A 1b2iA-4b61A:
undetectable		 1b2iA-4b61A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A  55
GLU A  51
GLU A 368
GLU A 100
 CU  A1505 (-2.3A)
None
None
None
 0.93A 1knyA-4b61A:
undetectable
1knyB-4b61A:
undetectable		 1knyA-4b61A:
18.83
1knyB-4b61A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 100
ASP A  55
GLU A  51
GLU A 368
 None
CU  A1505 (-2.3A)
None
None
 0.90A 1knyA-4b61A:
undetectable
1knyB-4b61A:
undetectable		 1knyA-4b61A:
18.83
1knyB-4b61A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 462
GLU A 368
GLY A 463
HIS A 480
GLY A  50
 78M  A1493 (-3.9A)
None
78M  A1493 (-3.7A)
78M  A1493 (-4.0A)
78M  A1499 ( 4.3A)
 0.95A 1n2xB-4b61A:
undetectable		 1n2xB-4b61A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 372
GLU A 373
GLY A 411
ILE A 415
LEU A  66
 None
 1.09A 1p91A-4b61A:
undetectable		 1p91A-4b61A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 419
GLY A 427
GLY A 468
TYR A 471
ILE A 415
 None
 1.21A 1p91A-4b61A:
undetectable		 1p91A-4b61A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 198
ARG A 204
ASP A 201
GLN A 345
ASN A 352
 None
 1.29A 1ulvA-4b61A:
1.2		 1ulvA-4b61A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 12 GLN A 387
ASP A 431
VAL A 397
HIS A 399
TYR A 264
 None
 1.45A 2g70B-4b61A:
undetectable		 2g70B-4b61A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 370
HIS A 364
ILE A 415
ASN A 352
TYR A 471
 None
 1.43A 2gl0B-4b61A:
undetectable
2gl0C-4b61A:
undetectable		 2gl0B-4b61A:
19.32
2gl0C-4b61A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 100
HIS A 364
GLU A 368
 None
 0.85A 2x45B-4b61A:
undetectable		 2x45B-4b61A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		3 / 3 GLU A 100
HIS A 364
GLU A 368
 None
 0.84A 2x45C-4b61A:
undetectable		 2x45C-4b61A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 352
ALA A 331
ALA A 379
GLN A 346
 None
 0.88A 3a2qA-4b61A:
undetectable		 3a2qA-4b61A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 10 PHE A 370
GLY A 367
VAL A 397
PHE A 401
THR A 381
 None
 1.36A 3a3yA-4b61A:
undetectable		 3a3yA-4b61A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_B_RBVB601_1
(RNA POLYMERASE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 9 ASP A 102
THR A 163
ASN A 164
LEU A 197
ARG A 119
 None
 1.33A 3sfuB-4b61A:
undetectable		 3sfuB-4b61A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 333
GLY A 311
THR A 279
LEU A 281
PHE A 366
 None
 1.08A 3sglA-4b61A:
undetectable		 3sglA-4b61A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  72
ARG A 371
ARG A 461
 None
 0.85A 4x5iA-4b61A:
undetectable		 4x5iA-4b61A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 162
ARG A 152
ARG A 154
LEU A 457
 None
 1.27A 5tuiB-4b61A:
0.5		 5tuiB-4b61A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A  51
GLU A 429
HIS A 399
THR A 412
GLY A 372
 None
 1.14A 5xipC-4b61A:
undetectable		 5xipC-4b61A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4b61 ALGINATE PRODUCTION
PROTEIN ALGE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 353
PHE A 483
ARG A 371
 None
 1.22A 5y9yA-4b61A:
undetectable		 5y9yA-4b61A:
22.11