SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b62'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 432
ASP A 376
GLY A 336
THR A 333
 None
 0.93A 1hxbB-4b62A:
undetectable		 1hxbB-4b62A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 321
VAL A 323
GLU A 338
LEU A 355
ILE A 358
 None
 1.32A 1t6zA-4b62A:
undetectable		 1t6zA-4b62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		5 / 11 VAL A 321
VAL A 323
GLU A 338
LEU A 355
ILE A 358
 None
 1.21A 1t6zB-4b62A:
undetectable		 1t6zB-4b62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 325
ARG A 305
ARG A 307
 None
 0.72A 2j9dA-4b62A:
undetectable
2j9dC-4b62A:
1.9		 2j9dA-4b62A:
24.84
2j9dC-4b62A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 365
ILE A 358
VAL A 332
VAL A 323
 None
 0.79A 3fi0B-4b62A:
undetectable		 3fi0B-4b62A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 365
ILE A 358
VAL A 332
VAL A 323
 None
 0.79A 3fi0G-4b62A:
undetectable		 3fi0G-4b62A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 8 VAL A 365
ILE A 358
VAL A 332
VAL A 323
 None
 0.77A 3fi0Q-4b62A:
undetectable		 3fi0Q-4b62A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		5 / 9 ALA A 361
LEU A 312
ILE A 334
LEU A 339
ILE A 441
 None
 1.28A 3jw3B-4b62A:
undetectable		 3jw3B-4b62A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 432
ASP A 376
GLY A 336
THR A 333
 None
 0.91A 3k4vC-4b62A:
undetectable		 3k4vC-4b62A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 7 THR A 414
LEU A 370
ILE A 441
THR A 442
 None
None
None
EDO  A1447 (-2.9A)
 0.98A 5zsfA-4b62A:
undetectable
5zsfB-4b62A:
undetectable		 5zsfA-4b62A:
17.20
5zsfB-4b62A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4b62 TSSL1
(Pseudomonas
aeruginosa) 		4 / 6 THR A 442
LEU A 370
THR A 333
LEU A 403
 EDO  A1447 (-2.9A)
None
None
None
 1.21A 6mvxA-4b62A:
undetectable
6mvxB-4b62A:
undetectable
6mvxC-4b62A:
undetectable		 6mvxA-4b62A:
20.00
6mvxB-4b62A:
20.00
6mvxC-4b62A:
20.00