SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b67'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 11 LEU A  82
LEU A  43
HIS A  40
ARG A 202
ALA A 200
 None
 1.47A 1hk3A-4b67A:
undetectable		 1hk3A-4b67A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		4 / 8 LEU A 416
GLU A 413
THR A 213
ILE A 208
 None
 1.02A 1qvtA-4b67A:
undetectable		 1qvtA-4b67A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 10 ALA A  75
LEU A  62
GLN A 486
GLY A 484
PHE A 483
 None
 1.22A 1uhoA-4b67A:
undetectable		 1uhoA-4b67A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		3 / 3 GLN A 342
HIS A 354
ARG A 273
 None
 0.92A 1zlqA-4b67A:
undetectable		 1zlqA-4b67A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 12 ILE A 277
VAL A 365
LEU A 220
MET A 216
ALA A 400
 None
 1.36A 2jj8C-4b67A:
undetectable		 2jj8C-4b67A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 12 SER A 417
VAL A 419
THR A 203
ILE A 451
PHE A 186
 None
 1.00A 2vdyB-4b67A:
undetectable		 2vdyB-4b67A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		4 / 7 GLY A 129
ILE A 132
THR A 135
LEU A 125
 SO4  A1496 (-3.2A)
SO4  A1496 (-3.7A)
None
None
 0.98A 2xrhA-4b67A:
undetectable		 2xrhA-4b67A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 12 VAL A 188
LEU A 415
ILE A  79
VAL A 168
ILE A 210
 None
None
None
FAD  A1492 (-3.8A)
FAD  A1492 (-3.5A)
 1.05A 3frqB-4b67A:
undetectable		 3frqB-4b67A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		4 / 4 ILE A 210
ARG A 423
ILE A 208
THR A 213
 FAD  A1492 (-3.5A)
None
None
None
 1.15A 3ia4C-4b67A:
undetectable		 3ia4C-4b67A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		3 / 3 LEU A 471
ARG A 144
ASN A 323
 None
FAD  A1492 ( 3.8A)
NAP  A1493 ( 2.9A)
 0.64A 3qxvD-4b67A:
undetectable		 3qxvD-4b67A:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		4 / 6 GLN A 102
ASP A 288
GLU A 294
LEU A 467
 NAP  A1493 (-4.0A)
None
None
FAD  A1492 (-3.8A)
 1.32A 4ax8A-4b67A:
2.4		 4ax8A-4b67A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 12 SER A 417
VAL A 419
THR A 203
ILE A 451
PHE A 186
 None
 0.92A 4c49A-4b67A:
undetectable		 4c49A-4b67A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 211
GLY A 212
SER A 466
ALA A 209
TRP A  90
 FAD  A1492 (-3.1A)
None
None
FAD  A1492 (-4.8A)
FAD  A1492 (-4.4A)
 0.86A 4htfA-4b67A:
2.7		 4htfA-4b67A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		5 / 12 GLY A 211
GLY A 212
SER A 466
ALA A 209
TRP A  90
 FAD  A1492 (-3.1A)
None
None
FAD  A1492 (-4.8A)
FAD  A1492 (-4.4A)
 0.92A 4htfB-4b67A:
2.7		 4htfB-4b67A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		3 / 3 TYR A 407
HIS A  91
MET A  94
 FAD  A1492 ( 4.4A)
FAD  A1492 ( 3.7A)
None
 1.13A 6af6A-4b67A:
undetectable		 6af6A-4b67A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4b67 L-ORNITHINE N5
MONOOXYGENASE
(Aspergillus
fumigatus) 		3 / 3 TYR A 269
ALA A 400
LEU A 236
 None
 0.68A 6d9kF-4b67A:
undetectable		 6d9kF-4b67A:
20.99