SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 4b6d RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 CYH A 319
ASP A 318
VAL A 321
CYH A 335
 ZN  A1341 ( 2.2A)
None
None
ZN  A1341 ( 2.3A)
 1.42A 1ekjG-4b6dA:
undetectable
1ekjH-4b6dA:
undetectable		 1ekjG-4b6dA:
13.44
1ekjH-4b6dA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4b6d RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 CYH A 303
ARG A 330
CYH A 300
 ZN  A1340 (-2.2A)
None
ZN  A1340 (-2.3A)
 1.28A 1p9gA-4b6dA:
undetectable		 1p9gA-4b6dA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4b6d RAC
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		3 / 3 CYH A 327
ARG A 330
CYH A 300
 ZN  A1340 (-2.3A)
None
ZN  A1340 (-2.3A)
 1.47A 1p9gA-4b6dA:
undetectable		 1p9gA-4b6dA:
16.36