SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b6g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		4 / 7 SER A 166
SER A  63
PHE A  65
PHE A 168
 None
 0.93A 1fxvA-4b6gA:
undetectable
1fxvB-4b6gA:
undetectable		 1fxvA-4b6gA:
21.68
1fxvB-4b6gA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		4 / 5 SER A  50
ALA A  78
ASP A  80
GLU A  56
 None
 1.14A 1lqtA-4b6gA:
undetectable
1lqtB-4b6gA:
undetectable		 1lqtA-4b6gA:
18.22
1lqtB-4b6gA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		4 / 5 SER A  50
ALA A  78
ASP A  80
GLU A  56
 None
 1.12A 1lquA-4b6gA:
undetectable
1lquB-4b6gA:
undetectable		 1lquA-4b6gA:
18.22
1lquB-4b6gA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 LEU A  52
ILE A 171
GLN A 227
ASP A  95
LEU A 188
 None
 1.10A 2jn3A-4b6gA:
undetectable		 2jn3A-4b6gA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 ILE A 263
ILE A  46
PHE A  59
TYR A 256
PHE A 168
 None
 1.04A 2oa1B-4b6gA:
1.4		 2oa1B-4b6gA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		4 / 8 ALA A 155
LEU A 152
ALA A 200
PHE A 233
 None
 0.81A 2vcvP-4b6gA:
undetectable		 2vcvP-4b6gA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		4 / 5 ILE A 263
HIS A 266
TYR A 256
GLY A 143
 None
 1.27A 3b9mA-4b6gA:
undetectable		 3b9mA-4b6gA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 MET A   1
ALA A  21
PHE A  30
LEU A   3
VAL A  77
 None
 1.27A 4ib4A-4b6gA:
undetectable		 4ib4A-4b6gA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.16A 4zdyA-4b6gA:
undetectable		 4zdyA-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.17A 4ze2A-4b6gA:
undetectable		 4ze2A-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 ALA A 167
GLY A 150
GLY A 148
GLY A  51
LEU A 154
 None
 0.96A 5c0oE-4b6gA:
undetectable		 5c0oE-4b6gA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 TYR A 256
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.34A 5esgA-4b6gA:
undetectable		 5esgA-4b6gA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.17A 5eslA-4b6gA:
undetectable		 5eslA-4b6gA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.27A 5v5zA-4b6gA:
undetectable		 5v5zA-4b6gA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 MET A 146
LEU A  52
ARG A  84
TYR A 120
ASP A  92
 None
 1.47A 5vlmC-4b6gA:
undetectable		 5vlmC-4b6gA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 GLY A 147
GLY A 143
PHE A 102
THR A  81
TYR A 256
 None
 1.48A 5yf0A-4b6gA:
undetectable		 5yf0A-4b6gA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4b6g PUTATIVE ESTERASE
(Neisseria
meningitidis) 		5 / 12 TYR A  94
PHE A 102
GLY A 180
HIS A 144
MET A 146
 None
 1.15A 6e8qA-4b6gA:
undetectable		 6e8qA-4b6gA:
13.92