SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b6i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 4b6i SMA2266
(Serratia
marcescens) 		5 / 11 SER A  66
LEU A  37
GLY A  76
PHE A  73
TYR A  83
 None
 1.48A 4foxC-4b6iA:
undetectable		 4foxC-4b6iA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4b6i SMA2266
(Serratia
marcescens) 		6 / 12 SER A  66
LEU A  37
GLY A  76
PHE A  73
TYR A  83
ALA A 107
 None
 1.48A 4foxD-4b6iA:
undetectable		 4foxD-4b6iA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4b6i SMA2266
(Serratia
marcescens) 		4 / 7 ARG A  40
GLY A  43
ASN A  85
GLN A  53
 None
 1.10A 4g0vA-4b6iA:
undetectable		 4g0vA-4b6iA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4b6i SMA2266
(Serratia
marcescens) 		4 / 7 LEU A  65
ALA A  61
LEU A  32
SER A  39
 None
 1.06A 4iklA-4b6iA:
undetectable
4iklB-4b6iA:
undetectable		 4iklA-4b6iA:
22.90
4iklB-4b6iA:
22.90