SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA205_1
(CARDIAC TROPONIN C)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		5 / 12 ALA A 117
ILE A 118
PHE A 124
PHE A  64
LEU A  49
 None
 0.92A 1dtlA-4b6jA:
undetectable		 1dtlA-4b6jA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		5 / 12 LEU A  80
LEU A  13
GLY A 150
ASP A 176
ALA A 162
 None
 1.13A 2bm9B-4b6jA:
2.6		 2bm9B-4b6jA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		5 / 12 ASP A 110
VAL A   4
LEU A 147
MET A 149
LEU A  84
 None
 1.10A 3s79A-4b6jA:
undetectable		 3s79A-4b6jA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		4 / 5 VAL A 168
LEU A 185
LEU A 182
ILE A   7
 None
 0.98A 4a9jA-4b6jA:
undetectable		 4a9jA-4b6jA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		5 / 10 ILE A   7
THR A  12
GLY A  11
GLY A 152
PHE A 159
 None
 1.19A 4bwlC-4b6jA:
undetectable		 4bwlC-4b6jA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		4 / 7 PHE A  64
PHE A  98
GLY A 126
PHE A  18
 None
 1.00A 4ejjB-4b6jA:
undetectable		 4ejjB-4b6jA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		5 / 12 PHE A 188
LEU A 177
LYS A   3
GLY A  88
LYS A  87
 None
 0.92A 4kykA-4b6jA:
undetectable
4kykB-4b6jA:
undetectable		 4kykA-4b6jA:
22.90
4kykB-4b6jA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		4 / 6 LYS A  70
ARG A  24
ALA A  23
MET A  22
 None
 1.40A 4o7gB-4b6jA:
0.0		 4o7gB-4b6jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		4 / 8 LEU A 185
THR A  83
LEU A  84
LEU A  80
 None
 0.71A 4z90F-4b6jA:
undetectable
4z90G-4b6jA:
undetectable
4z90H-4b6jA:
undetectable
4z90I-4b6jA:
undetectable
4z90J-4b6jA:
undetectable		 4z90F-4b6jA:
21.36
4z90G-4b6jA:
21.36
4z90H-4b6jA:
21.36
4z90I-4b6jA:
21.36
4z90J-4b6jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 4b6j PHOSPHOSERINE
PHOSPHATASE
(Thermococcus
onnurineus) 		5 / 12 ASP A 110
VAL A   4
LEU A 147
MET A 149
LEU A  84
 None
 1.08A 5jkvA-4b6jA:
undetectable		 5jkvA-4b6jA:
18.89