SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b6l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 5 PRO A 259
VAL A 275
TYR A 251
MET A 250
 None
 1.03A 1m8dA-4b6lA:
undetectable		 1m8dA-4b6lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 5 PRO A 259
VAL A 275
TYR A 251
MET A 250
 None
 1.04A 1m8dB-4b6lA:
undetectable		 1m8dB-4b6lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 5 PRO A 259
VAL A 275
TYR A 251
MET A 250
 None
 1.13A 1m9jA-4b6lA:
undetectable		 1m9jA-4b6lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 5 PRO A 259
VAL A 275
TYR A 251
MET A 250
 None
 1.11A 1m9jB-4b6lA:
undetectable		 1m9jB-4b6lA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 6 LEU A  68
LYS A  91
ILE A 137
ARG A 184
 9ZP  A1333 (-3.9A)
None
None
None
 1.07A 1opjB-4b6lA:
22.6		 1opjB-4b6lA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 LEU A 147
LEU A 188
GLY A 189
GLN A 168
THR A 194
 None
 1.23A 1p93A-4b6lA:
undetectable		 1p93A-4b6lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.56A 1uwhA-4b6lA:
24.5		 1uwhA-4b6lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
GLU A 110
LEU A 176
HIS A 183
GLY A 202
PHE A 192
 9ZP  A1333 (-3.5A)
None
None
None
9ZP  A1333 ( 4.4A)
9ZP  A1333 (-3.6A)
 1.28A 1uwhA-4b6lA:
24.5		 1uwhA-4b6lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 ALA A  89
LYS A  91
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.60A 1uwhB-4b6lA:
24.3		 1uwhB-4b6lA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.56A 1uwjA-4b6lA:
6.6		 1uwjA-4b6lA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.56A 1uwjB-4b6lA:
6.6		 1uwjB-4b6lA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 6 LEU A  68
VAL A 123
ILE A 137
ARG A 184
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-4.4A)
None
None
 0.85A 2hyyA-4b6lA:
23.0		 2hyyA-4b6lA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 10 LYS A  91
ILE A  93
LYS A 106
GLU A 110
ILE A 107
 None
 1.34A 2j9dD-4b6lA:
2.3
2j9dE-4b6lA:
1.6
2j9dF-4b6lA:
2.3		 2j9dD-4b6lA:
16.40
2j9dE-4b6lA:
17.39
2j9dF-4b6lA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 8 ILE A  93
LYS A 106
GLU A 110
ILE A 107
 None
 0.87A 2j9dJ-4b6lA:
2.2
2j9dK-4b6lA:
2.2
2j9dL-4b6lA:
2.0		 2j9dJ-4b6lA:
16.40
2j9dK-4b6lA:
16.40
2j9dL-4b6lA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 10 ARG A  66
LEU A  68
ALA A  89
LYS A  91
VAL A 123
LEU A 139
LEU A 141
 9ZP  A1333 (-3.3A)
9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.4A)
9ZP  A1333 (-3.8A)
9ZP  A1333 (-4.7A)
 0.72A 3aoxA-4b6lA:
23.5		 3aoxA-4b6lA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 LEU A  68
GLY A  69
ALA A  89
LYS A  91
VAL A 123
CYH A 142
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.6A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.4A)
9ZP  A1333 (-4.1A)
 0.58A 3c7qA-4b6lA:
22.2		 3c7qA-4b6lA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 9 LEU A  68
LYS A  91
ILE A 137
ARG A 184
VAL A 201
 9ZP  A1333 (-3.9A)
None
None
None
None
 1.01A 3oxzA-4b6lA:
22.8		 3oxzA-4b6lA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 6 LYS A  91
VAL A 123
ILE A 137
ARG A 184
 None
9ZP  A1333 (-4.4A)
None
None
 1.08A 3pyyA-4b6lA:
22.5		 3pyyA-4b6lA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 6 PRO A 258
TYR A 269
VAL A 227
THR A 262
 None
 1.10A 3tneA-4b6lA:
undetectable		 3tneA-4b6lA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 LEU A  68
ALA A  89
LEU A 139
LEU A 141
GLY A 202
ASP A 203
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
9ZP  A1333 (-3.8A)
9ZP  A1333 (-4.7A)
9ZP  A1333 ( 4.4A)
None
 0.62A 3zbfA-4b6lA:
25.5		 3zbfA-4b6lA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 PHE A 191
ALA A 241
SER A 245
GLY A 247
LEU A 246
 None
 0.97A 4e1gA-4b6lA:
undetectable		 4e1gA-4b6lA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 PHE A 191
ALA A 241
SER A 245
GLY A 247
LEU A 246
 None
 0.99A 4e1gB-4b6lA:
undetectable		 4e1gB-4b6lA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		3 / 3 ARG A 216
LEU A 210
GLU A 211
 None
 0.74A 4l3gF-4b6lA:
2.9		 4l3gF-4b6lA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 LEU A  68
ALA A  89
LYS A  91
LEU A 139
LEU A 141
ASP A 203
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-3.8A)
9ZP  A1333 (-4.7A)
None
 0.51A 4mkcA-4b6lA:
24.5		 4mkcA-4b6lA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 VAL A  90
ALA A  89
TYR A  88
SER A 126
THR A  54
 None
9ZP  A1333 (-3.5A)
None
None
None
 1.33A 4mm4A-4b6lA:
undetectable		 4mm4A-4b6lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 VAL A  90
ALA A  89
TYR A  88
SER A 126
THR A  54
 None
9ZP  A1333 (-3.5A)
None
None
None
 1.31A 4mm4B-4b6lA:
undetectable		 4mm4B-4b6lA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 7 ALA A  89
CYH A 142
ASN A 190
ASP A 203
 9ZP  A1333 (-3.5A)
9ZP  A1333 (-4.1A)
None
None
 0.22A 4ogrE-4b6lA:
28.9		 4ogrE-4b6lA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		3 / 3 GLN A 168
HIS A 121
ARG A 120
 None
 0.71A 4qyqA-4b6lA:
undetectable		 4qyqA-4b6lA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		3 / 3 GLN A 168
HIS A 121
ARG A 120
 None
 0.65A 4qyqB-4b6lA:
undetectable		 4qyqB-4b6lA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
ILE A 137
SER A 146
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.61A 4rzvA-4b6lA:
23.9		 4rzvA-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
SER A 146
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.92A 4rzvA-4b6lA:
23.9		 4rzvA-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
GLY A 205
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 1.36A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.97A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
CYH A 142
SER A 146
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.65A 4rzvB-4b6lA:
23.2		 4rzvB-4b6lA:
29.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
ASP A 203
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
None
 0.74A 4xv2A-4b6lA:
24.2		 4xv2A-4b6lA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
ASP A 203
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
None
 0.72A 4xv2B-4b6lA:
24.5		 4xv2B-4b6lA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.76A 5cswA-4b6lA:
24.0		 5cswA-4b6lA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 ALA A  89
LYS A  91
CYH A 142
PHE A 192
GLY A 202
PHE A 204
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
None
 0.79A 5cswB-4b6lA:
24.0		 5cswB-4b6lA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 LEU A  68
ALA A  89
ILE A 137
LEU A 141
GLY A 202
ASP A 203
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.7A)
9ZP  A1333 ( 4.4A)
None
 0.78A 5h2uB-4b6lA:
24.6		 5h2uB-4b6lA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 ALA A  89
LYS A  91
GLU A 110
CYH A 142
LEU A 176
HIS A 183
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.1A)
None
None
9ZP  A1333 ( 4.4A)
 0.66A 5hi2A-4b6lA:
24.4		 5hi2A-4b6lA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 ALA A  89
LYS A  91
ILE A 137
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.78A 5hieA-4b6lA:
23.1		 5hieA-4b6lA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 ALA A  89
LYS A  91
ILE A 137
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.81A 5hieB-4b6lA:
8.4		 5hieB-4b6lA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 ALA A  89
LYS A  91
ILE A 137
PHE A 192
GLY A 202
 9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.78A 5hieD-4b6lA:
23.2		 5hieD-4b6lA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 8 ALA A  89
GLU A 110
CYH A 142
ASP A 203
 9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
None
 0.43A 5owrA-4b6lA:
24.2		 5owrA-4b6lA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 12 ILE A 150
LEU A 188
LEU A 323
PHE A 313
GLY A 247
 None
 0.99A 5uxdB-4b6lA:
4.5		 5uxdB-4b6lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		6 / 12 GLY A  69
ALA A  89
GLU A 110
CYH A 142
PHE A 192
ASP A 203
 9ZP  A1333 (-3.6A)
9ZP  A1333 (-3.5A)
None
9ZP  A1333 (-4.1A)
9ZP  A1333 (-3.6A)
None
 0.83A 5vc3A-4b6lA:
28.1		 5vc3A-4b6lA:
28.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 LEU A  68
ALA A  89
LYS A  91
GLU A 110
VAL A 123
PHE A 192
GLY A 202
 9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.4A)
9ZP  A1333 (-3.6A)
9ZP  A1333 ( 4.4A)
 0.65A 5vcvA-4b6lA:
27.0		 5vcvA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 5 HIS A 114
LEU A 141
CYH A 142
ASP A 203
 None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
None
 0.72A 5vcvA-4b6lA:
27.0		 5vcvA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		4 / 4 VAL A 123
LEU A 141
ASN A 190
ASP A 203
 9ZP  A1333 (-4.4A)
9ZP  A1333 (-4.7A)
None
None
 0.79A 5vcyA-4b6lA:
26.9		 5vcyA-4b6lA:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 ARG A  66
LEU A  68
ALA A  89
LYS A  91
GLU A 110
LEU A 141
CYH A 142
 9ZP  A1333 (-3.3A)
9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
 0.74A 5y7zA-4b6lA:
28.2		 5y7zA-4b6lA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		7 / 12 ARG A  66
LEU A  68
ALA A  89
LYS A  91
GLU A 110
LEU A 141
CYH A 142
 9ZP  A1333 (-3.3A)
9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
 0.74A 5y7zA-4b6lA:
28.2		 5y7zA-4b6lA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens) 		5 / 9 LEU A 295
ARG A 296
PRO A 303
VAL A 243
ILE A 294
 None
 1.16A 6ef6A-4b6lA:
7.7		 6ef6A-4b6lA:
21.07