SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A 223
TRP A  40
GLY A  12
VAL A  75
 None
None
GOL  A1386 (-4.7A)
None
 0.88A 1dbbH-4b6zA:
undetectable
1dbbL-4b6zA:
undetectable		 1dbbH-4b6zA:
20.41
1dbbL-4b6zA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 5 SER A 246
ARG A 245
HIS A 268
HIS A 171
 None
None
ZN  A 385 (-3.2A)
ZN  A 385 ( 3.2A)
 1.49A 1s19A-4b6zA:
undetectable		 1s19A-4b6zA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 TYR A  78
CYH A  53
TYR A 108
LEU A   3
 None
 1.50A 1uw6D-4b6zA:
undetectable
1uw6E-4b6zA:
undetectable		 1uw6D-4b6zA:
20.82
1uw6E-4b6zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 LEU A   3
TYR A  78
CYH A  53
TYR A 108
 None
 1.48A 1uw6P-4b6zA:
undetectable
1uw6T-4b6zA:
undetectable		 1uw6P-4b6zA:
20.82
1uw6T-4b6zA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 7 ARG A  52
GLU A  51
PRO A  22
ALA A  24
 None
 1.39A 2ejgB-4b6zA:
undetectable		 2ejgB-4b6zA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 7 TYR A  65
GLU A 174
HIS A 268
GLY A 269
 None
ZN  A 385 (-2.1A)
ZN  A 385 (-3.2A)
None
 1.27A 2ha4B-4b6zA:
4.7		 2ha4B-4b6zA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 TYR A  43
GLY A  12
PHE A  41
 None
GOL  A1386 (-4.7A)
None
 0.68A 2m2pB-4b6zA:
undetectable		 2m2pB-4b6zA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 271
HIS A 171
GLU A 174
 None
ZN  A 385 ( 3.2A)
ZN  A 385 (-2.1A)
 0.70A 2x45B-4b6zA:
undetectable		 2x45B-4b6zA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 344
HIS A 171
GLU A 174
 ZN  A 385 ( 4.9A)
ZN  A 385 ( 3.2A)
ZN  A 385 (-2.1A)
 0.83A 2x45B-4b6zA:
undetectable		 2x45B-4b6zA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 271
HIS A 171
GLU A 174
 None
ZN  A 385 ( 3.2A)
ZN  A 385 (-2.1A)
 0.71A 2x45C-4b6zA:
undetectable		 2x45C-4b6zA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 GLU A 344
HIS A 171
GLU A 174
 ZN  A 385 ( 4.9A)
ZN  A 385 ( 3.2A)
ZN  A 385 (-2.1A)
 0.86A 2x45C-4b6zA:
undetectable		 2x45C-4b6zA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 4 ASP A 272
ASP A 270
GLY A 314
THR A 342
 None
 1.37A 3tl9B-4b6zA:
undetectable		 3tl9B-4b6zA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.75A 3u5kA-4b6zA:
undetectable		 3u5kA-4b6zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 7 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.80A 3u5kB-4b6zA:
undetectable		 3u5kB-4b6zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.74A 3u5kC-4b6zA:
undetectable		 3u5kC-4b6zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.92A 3u5kD-4b6zA:
undetectable		 3u5kD-4b6zA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 PHE A  84
VAL A  86
MET A  55
ILE A  97
 None
 1.08A 4a97G-4b6zA:
0.6		 4a97G-4b6zA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 5 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.82A 4a9jA-4b6zA:
undetectable		 4a9jA-4b6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 5 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.83A 4a9jB-4b6zA:
undetectable		 4a9jB-4b6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 5 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.89A 4a9jC-4b6zA:
undetectable		 4a9jC-4b6zA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 TYR A  72
ARG A  85
SER A  73
 None
 1.02A 4dr2I-4b6zA:
undetectable
4dr2J-4b6zA:
undetectable		 4dr2I-4b6zA:
15.72
4dr2J-4b6zA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 TYR A  72
ARG A  85
SER A  73
 None
 1.03A 4lf7I-4b6zA:
undetectable
4lf7J-4b6zA:
0.3		 4lf7I-4b6zA:
15.72
4lf7J-4b6zA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		3 / 3 TYR A  72
ARG A  85
SER A  73
 None
 1.03A 4lf8I-4b6zA:
undetectable
4lf8J-4b6zA:
0.3		 4lf8I-4b6zA:
15.72
4lf8J-4b6zA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 6 GLU A 117
ASP A  10
ASN A 214
ARG A 169
 None
 1.38A 4ntxA-4b6zA:
undetectable
4ntxC-4b6zA:
undetectable		 4ntxA-4b6zA:
21.56
4ntxC-4b6zA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA207_0
(OXIDOREDUCTASE)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 4 GLU A 271
GLY A 269
HIS A 171
ARG A 226
 None
None
ZN  A 385 ( 3.2A)
ACT  A1387 (-2.8A)
 1.49A 4r82A-4b6zA:
undetectable
4r82B-4b6zA:
undetectable		 4r82A-4b6zA:
18.32
4r82B-4b6zA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 7 ALA A  76
ASP A 104
ARG A  49
GLY A  50
 None
 0.86A 5btgA-4b6zA:
undetectable
5btgC-4b6zA:
undetectable
5btgD-4b6zA:
3.8		 5btgA-4b6zA:
21.58
5btgC-4b6zA:
21.58
5btgD-4b6zA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 166
PHE A 209
ALA A 375
LEU A 203
VAL A 164
 None
 0.90A 5km9B-4b6zA:
undetectable		 5km9B-4b6zA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 332
ARG A 253
PHE A 336
GLY A 337
GLY A 333
 None
 0.97A 5l6eA-4b6zA:
undetectable		 5l6eA-4b6zA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 5 LEU A 129
PHE A 122
LEU A 149
TRP A 191
 None
 0.74A 5m10A-4b6zA:
undetectable		 5m10A-4b6zA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 5 HIS A 119
ASP A 218
GLY A 219
ASN A 214
 None
 1.32A 5x7pB-4b6zA:
2.9		 5x7pB-4b6zA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 8 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.71A 5y1yA-4b6zA:
undetectable		 5y1yA-4b6zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		5 / 12 THR A 153
VAL A 378
LEU A 377
PHE A 209
VAL A 164
 None
 0.89A 6drzA-4b6zA:
undetectable		 6drzA-4b6zA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4b6z FAMILY M14
UNASSIGNED PEPTIDASE
(Burkholderia
cenocepacia) 		4 / 7 ILE A 167
GLN A 170
GLU A 237
VAL A 252
 None
 1.04A 6j20A-4b6zA:
undetectable		 6j20A-4b6zA:
19.96