SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b7l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4b7l FILAMIN-B
(Homo
sapiens) 		3 / 3 TRP A 128
VAL A 127
PRO A 126
 None
 0.97A 1rg1A-4b7lA:
undetectable		 1rg1A-4b7lA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 4b7l FILAMIN-B
(Homo
sapiens) 		3 / 3 TRP A 128
VAL A 127
PRO A 126
 None
 0.96A 1rh0A-4b7lA:
undetectable		 1rh0A-4b7lA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 4b7l FILAMIN-B
(Homo
sapiens) 		4 / 4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.91A 1ya4B-4b7lA:
undetectable		 1ya4B-4b7lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4b7l FILAMIN-B
(Homo
sapiens) 		4 / 4 LEU A  53
PRO A 126
ILE A 118
LEU A 117
 None
 0.96A 1ya4C-4b7lA:
undetectable		 1ya4C-4b7lA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 4b7l FILAMIN-B
(Homo
sapiens) 		5 / 7 LEU A 234
TRP A 165
ALA A 170
GLY A 172
PHE A 237
 None
 1.32A 2wq5A-4b7lA:
undetectable		 2wq5A-4b7lA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 4b7l FILAMIN-B
(Homo
sapiens) 		5 / 10 ALA A  83
LEU A  94
LEU A  84
HIS A 120
LEU A 117
 None
 1.23A 3erdB-4b7lA:
undetectable		 3erdB-4b7lA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4b7l FILAMIN-B
(Homo
sapiens) 		4 / 7 LYS A 255
ALA A 257
THR A 281
VAL A 279
 None
 0.87A 3ozkB-4b7lA:
undetectable		 3ozkB-4b7lA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4b7l FILAMIN-B
(Homo
sapiens) 		5 / 12 ILE A  97
LEU A  87
VAL A  80
LEU A  54
GLY A 105
 None
 0.83A 3uq6B-4b7lA:
undetectable		 3uq6B-4b7lA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4b7l FILAMIN-B
(Homo
sapiens) 		5 / 11 ALA A  83
LEU A  94
LEU A  84
HIS A 120
LEU A 117
 None
 1.28A 4zn7B-4b7lA:
undetectable		 4zn7B-4b7lA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4b7l FILAMIN-B
(Homo
sapiens) 		5 / 12 GLY A 285
ASN A 312
ALA A 334
ALA A 284
ALA A 257
 None
 0.92A 5zw4A-4b7lA:
undetectable		 5zw4A-4b7lA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4b7l FILAMIN-B
(Homo
sapiens) 		3 / 3 LEU A 107
GLN A  41
LYS A  13
 None
 0.99A 6exiA-4b7lA:
undetectable		 6exiA-4b7lA:
13.39