SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b7x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A  58
ARG A  14
ILE A  68
 None
 0.82A 1a4gB-4b7xA:
undetectable		 1a4gB-4b7xA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  98
PHE A 111
GLY A 106
GLY A  32
LEU A  31
 None
 0.96A 1fe2A-4b7xA:
undetectable		 1fe2A-4b7xA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 GLU A 183
ALA A 179
LEU A 188
ALA A 157
GLY A 328
 None
NAP  A 400 (-3.7A)
None
None
None
 1.29A 1mjqG-4b7xA:
undetectable
1mjqH-4b7xA:
undetectable		 1mjqG-4b7xA:
13.03
1mjqH-4b7xA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 178
ALA A 179
ALA A 157
ILE A 217
CYH A 213
 None
NAP  A 400 (-3.7A)
None
None
None
 1.06A 2aclC-4b7xA:
undetectable		 2aclC-4b7xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 178
ALA A 179
ALA A 157
ILE A 217
CYH A 213
 None
NAP  A 400 (-3.7A)
None
None
None
 1.06A 2aclE-4b7xA:
undetectable		 2aclE-4b7xA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 165
ALA A 164
GLY A 155
ILE A 178
VAL A 243
 None
None
NAP  A 400 ( 4.7A)
None
None
 1.02A 2f80A-4b7xA:
undetectable		 2f80A-4b7xA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 165
ALA A 164
GLY A 155
ILE A 178
VAL A 243
 None
None
NAP  A 400 ( 4.7A)
None
None
 1.01A 2f81A-4b7xA:
undetectable		 2f81A-4b7xA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 161
ALA A 135
GLY A 132
ALA A 127
LEU A 139
 None
 0.96A 2nyuA-4b7xA:
8.6		 2nyuA-4b7xA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 139
ASP A 141
MET A 292
LEU A 301
 None
 1.31A 2qxsA-4b7xA:
undetectable		 2qxsA-4b7xA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 139
ASP A 141
MET A 292
LEU A 301
 None
 1.32A 2qxsB-4b7xA:
undetectable		 2qxsB-4b7xA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  99
LEU A  46
LEU A 332
PHE A  24
 None
 0.84A 2vctB-4b7xA:
undetectable		 2vctB-4b7xA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 200
VAL A 224
GLY A 226
SER A 249
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.6A)
None
NAP  A 400 (-4.9A)
 0.49A 2wekB-4b7xA:
37.7		 2wekB-4b7xA:
30.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 228
GLY A 155
SER A 154
ALA A 159
VAL A 160
 None
NAP  A 400 ( 4.7A)
None
NAP  A 400 (-3.4A)
NAP  A 400 (-3.8A)
 0.79A 2yvlA-4b7xA:
8.9		 2yvlA-4b7xA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A 154
GLY A 225
GLY A 246
 None
None
NAP  A 400 (-3.4A)
 0.43A 3bogA-4b7xA:
undetectable
3bogC-4b7xA:
undetectable		 3bogA-4b7xA:
undetectable
3bogC-4b7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 SER A 154
GLY A 155
GLY A 225
GLY A 246
 None
NAP  A 400 ( 4.7A)
None
NAP  A 400 (-3.4A)
 0.72A 3bogB-4b7xA:
undetectable
3bogD-4b7xA:
undetectable		 3bogB-4b7xA:
undetectable
3bogD-4b7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 178
ALA A 179
ALA A 157
ILE A 217
CYH A 213
 None
NAP  A 400 (-3.7A)
None
None
None
 1.10A 3falA-4b7xA:
undetectable		 3falA-4b7xA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 160
VAL A 163
LEU A 301
SER A 162
GLY A 132
 NAP  A 400 (-3.8A)
None
None
None
None
 1.22A 3ls4H-4b7xA:
undetectable		 3ls4H-4b7xA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 6 MET A 276
ILE A 236
ILE A 217
VAL A 232
 NAP  A 400 (-3.6A)
None
None
None
 0.74A 4olmA-4b7xA:
undetectable		 4olmA-4b7xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 5 ASN A   6
GLN A 101
ASP A 102
ARG A   7
 None
 1.35A 5w4zA-4b7xA:
undetectable		 5w4zA-4b7xA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		4 / 4 PHE A 137
LEU A 296
LEU A 289
VAL A 163
 None
 1.15A 5xxiA-4b7xA:
undetectable		 5xxiA-4b7xA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4b7x PROBABLE
OXIDOREDUCTASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 153
ALA A 159
GLY A 132
PHE A 221
ALA A 138
 None
NAP  A 400 (-3.4A)
None
None
None
 1.20A 6ieyA-4b7xA:
2.8
6ieyB-4b7xA:
2.5		 6ieyA-4b7xA:
24.93
6ieyB-4b7xA:
24.93