SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b8a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		3 / 3 PHE B   7
TYR B  13
PRO B   9
 None
 0.90A 1mcnA-4b8aB:
undetectable
1mcnB-4b8aB:
undetectable
1mcnP-4b8aB:
undetectable		 1mcnA-4b8aB:
21.13
1mcnB-4b8aB:
21.13
1mcnP-4b8aB:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 GLN B 260
PRO B   9
GLY B  90
LEU B 252
SER B  84
 None
 1.35A 2nv4B-4b8aB:
undetectable		 2nv4B-4b8aB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 964
PRO A 995
ILE A 963
LYS A 968
 None
 1.07A 2qeuA-4b8aA:
undetectable
2qeuC-4b8aA:
1.5		 2qeuA-4b8aA:
19.42
2qeuC-4b8aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 ILE B 126
GLN B  80
PHE B 102
SER B  44
ILE B  43
 None
 1.24A 3iw1A-4b8aB:
undetectable		 3iw1A-4b8aB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 199
LEU B 200
ILE B 207
LEU B 261
LEU B 232
 None
 0.91A 3k2hA-4b8aB:
undetectable		 3k2hA-4b8aB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		4 / 8 LYS B 125
ASN B 127
ASN B 103
ILE B  79
 None
 1.34A 3kp6A-4b8aB:
undetectable
3kp6B-4b8aB:
undetectable		 3kp6A-4b8aB:
20.85
3kp6B-4b8aB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		4 / 5 LEU B  81
GLY B  82
PHE B 102
PHE B 141
 None
 1.00A 3smtA-4b8aB:
undetectable		 3smtA-4b8aB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 774
MET A 771
ASP A 881
 None
 0.84A 3v5wA-4b8aA:
undetectable		 3v5wA-4b8aA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 934
PHE A 915
ALA A 914
LEU A 774
 None
 0.74A 4ejgA-4b8aA:
undetectable		 4ejgA-4b8aA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 VAL A 935
VAL A 932
VAL A 931
ILE A 999
LEU A 962
 None
 1.05A 5e4dB-4b8aA:
undetectable		 5e4dB-4b8aA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 964
PRO A 995
ILE A 963
LEU A 961
 None
 1.28A 5m45A-4b8aA:
undetectable		 5m45A-4b8aA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 964
PRO A 995
ILE A 963
LEU A 961
 None
 1.30A 5m45D-4b8aA:
undetectable		 5m45D-4b8aA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 964
PRO A 995
ILE A 963
LEU A 961
 None
 1.26A 5m45G-4b8aA:
undetectable		 5m45G-4b8aA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 GLU A 964
PRO A 995
ILE A 963
LEU A 961
 None
 1.32A 5m45J-4b8aA:
undetectable		 5m45J-4b8aA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4b8a GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 ASN A 952
ILE B 171
LEU B 174
MET B 146
 None
 1.07A 5u4sB-4b8aA:
undetectable		 5u4sB-4b8aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 ASN B 172
VAL B  73
MET B  69
ASP B 166
LEU B  83
 None
 1.23A 5x24A-4b8aB:
undetectable		 5x24A-4b8aB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B  28
ALA B  88
ILE B  43
MET B 151
LEU B  85
 None
 1.21A 6aybA-4b8aB:
undetectable		 6aybA-4b8aB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B  19
ASP B  18
LEU B 170
LEU B 145
GLY B 248
 None
 1.07A 6b0iB-4b8aB:
undetectable		 6b0iB-4b8aB:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4b8a POLY(A) RIBONUCLEASE
POP2
(Saccharomyces
cerevisiae) 		5 / 12 VAL B  19
ASP B  18
LEU B 170
LEU B 145
GLY B 248
 None
 1.02A 6b0lB-4b8aB:
undetectable		 6b0lB-4b8aB:
18.89