SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 286
ILE A 291
LEU A 352
LEU A 281
PHE A 321
 None
 1.08A 1axwA-4b8bA:
undetectable		 1axwA-4b8bA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 447
ILE A 448
ALA A 456
LEU A 468
ILE A 490
 None
None
AU  A1749 ( 3.9A)
None
AU  A1749 (-4.6A)
 1.15A 1bsxA-4b8bA:
undetectable		 1bsxA-4b8bA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 447
ILE A 448
ALA A 456
LEU A 468
ILE A 490
 None
None
AU  A1749 ( 3.9A)
None
AU  A1749 (-4.6A)
 1.15A 1bsxB-4b8bA:
undetectable		 1bsxB-4b8bA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 THR A 465
LEU A 462
VAL A 471
LEU A 475
 None
 1.00A 1fbmB-4b8bA:
undetectable		 1fbmB-4b8bA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.17A 1fbyA-4b8bA:
undetectable		 1fbyA-4b8bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.14A 1fbyB-4b8bA:
undetectable		 1fbyB-4b8bA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.17A 1fm6A-4b8bA:
undetectable		 1fm6A-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.14A 1fm9A-4b8bA:
undetectable		 1fm9A-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 634
LEU A 675
ARG A 676
LEU A 567
 None
 0.90A 1hk3A-4b8bA:
undetectable		 1hk3A-4b8bA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.12A 1k74A-4b8bA:
undetectable		 1k74A-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 THR A 465
LEU A 462
VAL A 471
LEU A 475
 None
 0.96A 1mz9D-4b8bA:
undetectable		 1mz9D-4b8bA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 644
VAL A 618
LEU A 621
LEU A 605
 None
 0.78A 1pthA-4b8bA:
undetectable		 1pthA-4b8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 644
VAL A 618
LEU A 621
LEU A 605
 None
 0.77A 1pthB-4b8bA:
undetectable		 1pthB-4b8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.14A 1xdkE-4b8bA:
undetectable		 1xdkE-4b8bA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.14A 1xiuA-4b8bA:
undetectable		 1xiuA-4b8bA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.19A 1xlsA-4b8bA:
undetectable		 1xlsA-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.19A 1xlsB-4b8bA:
undetectable		 1xlsB-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.19A 1xlsC-4b8bA:
undetectable		 1xlsC-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.19A 1xlsD-4b8bA:
undetectable		 1xlsD-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 258
VAL A 290
ILE A 291
LEU A 352
ILE A 349
 None
 1.15A 1yatA-4b8bA:
undetectable		 1yatA-4b8bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 258
VAL A 290
LEU A 352
ILE A 349
PHE A 282
 None
 1.12A 1yatA-4b8bA:
undetectable		 1yatA-4b8bA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 459
LEU A 462
LEU A 475
LEU A 484
 None
 1.03A 2ab2A-4b8bA:
undetectable		 2ab2A-4b8bA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.76A 2aclG-4b8bA:
undetectable		 2aclG-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 485
LEU A 531
ARG A 488
GLY A 491
 None
AU  A1749 (-3.7A)
None
None
 1.22A 2hs2B-4b8bA:
undetectable		 2hs2B-4b8bA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 273
TRP A 299
LEU A 281
ILE A 208
 None
 0.81A 2q83B-4b8bA:
undetectable		 2q83B-4b8bA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 241
GLU A 207
LEU A 281
ILE A 291
LEU A 323
 None
 1.29A 2zzaA-4b8bA:
undetectable		 2zzaA-4b8bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 241
GLU A 207
LEU A 281
ILE A 291
LEU A 323
 None
 1.29A 2zzaB-4b8bA:
undetectable		 2zzaB-4b8bA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 455
ILE A 490
ALA A 487
VAL A 471
LEU A 462
 None
AU  A1749 (-4.6A)
None
None
None
 1.11A 3a51E-4b8bA:
undetectable		 3a51E-4b8bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.76A 3falC-4b8bA:
undetectable		 3falC-4b8bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.75A 3fc6A-4b8bA:
undetectable		 3fc6A-4b8bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 241
GLU A 207
LEU A 281
ILE A 291
LEU A 323
 None
 1.30A 3ia4B-4b8bA:
undetectable		 3ia4B-4b8bA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_1
(DIHYDROFOLATE
REDUCTASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 241
GLU A 207
LEU A 281
ILE A 291
LEU A 323
 None
 1.30A 3ia4C-4b8bA:
undetectable		 3ia4C-4b8bA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 443
LEU A 462
VAL A 471
ILE A 455
ILE A 448
 None
 1.15A 3jw3A-4b8bA:
undetectable		 3jw3A-4b8bA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 644
VAL A 618
LEU A 621
LEU A 665
LEU A 605
 None
 0.97A 3n8wA-4b8bA:
undetectable		 3n8wA-4b8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 644
VAL A 618
LEU A 621
LEU A 665
LEU A 605
 None
 1.00A 3n8zA-4b8bA:
undetectable		 3n8zA-4b8bA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 475
ILE A 447
ALA A 443
ILE A 434
GLY A 466
 None
None
None
AU  A1752 ( 4.2A)
None
 1.04A 3nxuA-4b8bA:
undetectable		 3nxuA-4b8bA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.19A 3oapA-4b8bA:
undetectable		 3oapA-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 392
ILE A 411
PHE A 357
PHE A 376
 AU  A1752 ( 4.6A)
None
AU  A1755 (-4.6A)
None
 1.12A 3owxB-4b8bA:
undetectable		 3owxB-4b8bA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 SER A 733
VAL A 728
LEU A 731
GLU A 693
ALA A 691
 None
 1.24A 4e0fA-4b8bA:
undetectable		 4e0fA-4b8bA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 281
PHE A 282
TRP A 314
PRO A 273
 None
 1.22A 4j7uD-4b8bA:
undetectable		 4j7uD-4b8bA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.68A 4k6iA-4b8bA:
undetectable		 4k6iA-4b8bA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.72A 4nqaH-4b8bA:
undetectable		 4nqaH-4b8bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 303
ILE A 291
LEU A 281
PHE A 282
 None
 0.95A 4uymA-4b8bA:
undetectable		 4uymA-4b8bA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 258
VAL A 290
ILE A 291
LEU A 352
ILE A 349
 None
 1.09A 5b8iC-4b8bA:
undetectable		 5b8iC-4b8bA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 258
VAL A 290
LEU A 352
ILE A 349
PHE A 282
 None
 1.15A 5b8iC-4b8bA:
undetectable		 5b8iC-4b8bA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 397
SER A 351
SER A 348
SER A 296
 None
 1.48A 5hswA-4b8bA:
undetectable		 5hswA-4b8bA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 581
GLY A 579
HIS A 540
ASN A 575
 None
 0.91A 5nnwD-4b8bA:
undetectable		 5nnwD-4b8bA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 581
GLY A 579
HIS A 540
ASN A 575
 None
 0.92A 5no9D-4b8bA:
undetectable		 5no9D-4b8bA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 512
LEU A 551
ILE A 543
LEU A 515
LEU A 499
 None
 1.16A 5og9B-4b8bA:
undetectable		 5og9B-4b8bA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.11A 5uanA-4b8bA:
undetectable		 5uanA-4b8bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
VAL A 728
 None
 1.17A 5z12B-4b8bA:
undetectable		 5z12B-4b8bA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.79A 5z12C-4b8bA:
undetectable		 5z12C-4b8bA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.79A 6a5yD-4b8bA:
undetectable		 6a5yD-4b8bA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.80A 6a5zD-4b8bA:
undetectable		 6a5zD-4b8bA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 741
ALA A 744
ALA A 745
LEU A 714
ALA A 715
 None
 0.79A 6a5zL-4b8bA:
undetectable		 6a5zL-4b8bA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 472
LEU A 499
PHE A 495
PHE A 534
ILE A 448
 None
 1.13A 6dwnC-4b8bA:
undetectable		 6dwnC-4b8bA:
7.65