SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		3 / 3 TRP A 138
VAL A 174
TRP A 180
 None
 1.15A 1c4dA-4b8jA:
undetectable
1c4dB-4b8jA:
undetectable		 1c4dA-4b8jA:
3.39
1c4dB-4b8jA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		3 / 3 GLU A 490
LYS A 484
VAL A 486
 None
 0.97A 1l2iA-4b8jA:
undetectable		 1l2iA-4b8jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 ILE A 488
GLY A 435
ALA A 396
SER A 398
TYR A 492
 None
 1.38A 1nbhA-4b8jA:
undetectable		 1nbhA-4b8jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 ILE A 488
GLY A 435
ALA A 396
SER A 398
TYR A 492
 None
 1.38A 1nbhD-4b8jA:
undetectable		 1nbhD-4b8jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 5 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.16A 1t88B-4b8jA:
undetectable		 1t88B-4b8jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		3 / 3 ARG A  97
SER A  83
TYR A  82
 None
 0.74A 1x70A-4b8jA:
undetectable		 1x70A-4b8jA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 LEU A 293
LEU A 305
ILE A 351
LEU A 335
LEU A 332
 None
 1.01A 2bdmA-4b8jA:
undetectable		 2bdmA-4b8jA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 10 ALA A 262
GLN A 208
LEU A 205
LEU A 209
ASN A 220
 None
 1.39A 2ceoB-4b8jA:
undetectable		 2ceoB-4b8jA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 8 LEU A 292
ILE A 251
HIS A 252
GLY A 284
 None
 0.93A 3b9lA-4b8jA:
undetectable		 3b9lA-4b8jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 VAL A 280
GLY A 284
ILE A 251
THR A 307
LEU A 289
 None
 1.36A 3bexC-4b8jA:
undetectable
3bexD-4b8jA:
undetectable		 3bexC-4b8jA:
20.61
3bexD-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 THR A 307
LEU A 289
VAL A 280
GLY A 284
ILE A 251
 None
 1.36A 3bexE-4b8jA:
undetectable
3bexF-4b8jA:
undetectable		 3bexE-4b8jA:
20.61
3bexF-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 VAL A 280
GLY A 284
ILE A 251
THR A 307
LEU A 289
 None
 1.36A 3bf1A-4b8jA:
undetectable
3bf1B-4b8jA:
undetectable		 3bf1A-4b8jA:
20.61
3bf1B-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 VAL A 280
GLY A 284
ILE A 251
THR A 307
LEU A 289
 None
 1.35A 3bf1C-4b8jA:
undetectable
3bf1D-4b8jA:
undetectable		 3bf1C-4b8jA:
20.61
3bf1D-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 THR A 307
LEU A 289
VAL A 280
GLY A 284
ILE A 251
 None
 1.35A 3bf1C-4b8jA:
undetectable
3bf1D-4b8jA:
undetectable		 3bf1C-4b8jA:
20.61
3bf1D-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 VAL A 280
GLY A 284
ILE A 251
THR A 307
LEU A 289
 None
 1.35A 3bf1E-4b8jA:
undetectable
3bf1F-4b8jA:
undetectable		 3bf1E-4b8jA:
20.61
3bf1F-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 THR A 307
LEU A 289
VAL A 280
GLY A 284
ILE A 251
 None
 1.32A 3bf1E-4b8jA:
undetectable
3bf1F-4b8jA:
undetectable		 3bf1E-4b8jA:
20.61
3bf1F-4b8jA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.14A 3fwgA-4b8jA:
undetectable		 3fwgA-4b8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 LEU A 467
LEU A 433
LEU A 436
LEU A 440
LEU A 473
 None
 0.91A 3hm1A-4b8jA:
undetectable		 3hm1A-4b8jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		3 / 3 ILE A 439
SER A 394
SER A 398
 None
 0.64A 3iltH-4b8jA:
undetectable		 3iltH-4b8jA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 GLY A 309
THR A 350
SER A 267
ILE A 277
ARG A  27
 None
 1.34A 3iv6C-4b8jA:
undetectable		 3iv6C-4b8jA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 ILE A 155
ALA A 201
ALA A 186
VAL A 185
ASN A 184
 None
 1.06A 3jb3A-4b8jA:
undetectable		 3jb3A-4b8jA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.10A 3wrhE-4b8jA:
undetectable		 3wrhE-4b8jA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 THR A 307
GLY A 309
ILE A 322
LEU A 305
 None
 1.11A 4ac9C-4b8jA:
undetectable		 4ac9C-4b8jA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 THR A 307
GLY A 309
ILE A 322
LEU A 305
 None
 1.08A 4acaC-4b8jA:
undetectable		 4acaC-4b8jA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 THR A 307
GLY A 309
ILE A 322
LEU A 305
 None
 1.07A 4acbC-4b8jA:
undetectable		 4acbC-4b8jA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 11 SER A 114
GLY A 115
ILE A 108
LEU A 100
ILE A 143
 None
 1.04A 4dt8A-4b8jA:
undetectable		 4dt8A-4b8jA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.11A 4ek1A-4b8jA:
undetectable		 4ek1A-4b8jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 LEU A 205
ALA A 243
TRP A 223
ALA A 221
THR A 222
 None
 1.13A 4fiaA-4b8jA:
undetectable		 4fiaA-4b8jA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		5 / 12 LEU A 205
ALA A 243
TRP A 223
ALA A 221
THR A 222
 None
 1.13A 4fiaA-4b8jA:
undetectable		 4fiaA-4b8jA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.09A 4g3rA-4b8jA:
undetectable		 4g3rA-4b8jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 5 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.16A 4l49A-4b8jA:
undetectable		 4l49A-4b8jA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 6 PHE A 228
LEU A 167
VAL A 164
VAL A 185
 None
 1.09A 4l4cA-4b8jA:
undetectable		 4l4cA-4b8jA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 4 VAL A 300
THR A 260
GLU A 256
GLU A 257
 None
 1.29A 4l78A-4b8jA:
undetectable		 4l78A-4b8jA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 7 ARG A  29
PHE A 383
ASP A 425
ILE A 428
 None
 1.31A 5a06B-4b8jA:
undetectable		 5a06B-4b8jA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4b8j IMPORTIN SUBUNIT
ALPHA-1A
(Oryza
sativa) 		4 / 5 LEU A 440
MET A 460
CYH A 418
CYH A 413
 None
 1.32A 5te0A-4b8jA:
undetectable		 5te0A-4b8jA:
22.39