SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 8 GLY A 123
HIS A 140
THR A  39
ILE A 118
 None
 0.82A 1c9sU-4b8sA:
undetectable
1c9sV-4b8sA:
undetectable		 1c9sU-4b8sA:
10.02
1c9sV-4b8sA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 11 LEU A 245
LEU A 266
LEU A 292
VAL A 217
ILE A 239
 None
 1.31A 1ee2A-4b8sA:
2.1		 1ee2A-4b8sA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 11 SER A 376
TYR A 133
ILE A 453
ALA A 457
SER A 460
 None
 1.07A 1eqgB-4b8sA:
undetectable		 1eqgB-4b8sA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 6 ASN A  38
ASN A  40
ILE A 124
GLY A 119
 GLC  A 468 (-4.6A)
GLC  A 468 ( 4.1A)
None
GLC  A 468 (-3.5A)
 0.97A 1oniA-4b8sA:
undetectable
1oniB-4b8sA:
undetectable		 1oniA-4b8sA:
12.97
1oniB-4b8sA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 6 ASN A  38
ASN A  40
ILE A 124
GLY A 119
 GLC  A 468 (-4.6A)
GLC  A 468 ( 4.1A)
None
GLC  A 468 (-3.5A)
 1.02A 1oniD-4b8sA:
undetectable
1oniF-4b8sA:
undetectable		 1oniD-4b8sA:
12.97
1oniF-4b8sA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		3 / 3 ASP A 451
GLU A 308
TYR A 354
 GLC  A 468 (-2.9A)
GOL  A1468 (-2.9A)
AMP  A1472 ( 4.0A)
 0.79A 1wsvA-4b8sA:
undetectable		 1wsvA-4b8sA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ARG A 348
PHE A  20
ALA A 457
ILE A 394
ILE A 391
 None
 1.29A 2bjfA-4b8sA:
undetectable		 2bjfA-4b8sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 11 ILE A  85
LEU A  47
PHE A 189
ARG A  87
LYS A  90
 None
 1.37A 2bxmA-4b8sA:
undetectable		 2bxmA-4b8sA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 4 ASP A  42
ASP A 451
ASP A 211
GLY A 123
 GLC  A 468 (-2.7A)
GLC  A 468 (-2.9A)
None
None
 1.39A 2igtC-4b8sA:
3.8		 2igtC-4b8sA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		3 / 3 ARG A 390
GLU A 392
GLN A 393
 None
 1.03A 2p16A-4b8sA:
undetectable		 2p16A-4b8sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.36A 2pkkA-4b8sA:
17.9		 2pkkA-4b8sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.36A 2pkmA-4b8sA:
17.7		 2pkmA-4b8sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ALA A 281
GLU A 308
MET A 125
ILE A 124
GLY A 120
 GOL  A1468 ( 3.9A)
GOL  A1468 (-2.9A)
None
None
GLC  A 468 (-3.6A)
 1.04A 2yjaB-4b8sA:
undetectable		 2yjaB-4b8sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 GLN A 121
SER A 456
GLY A 448
GLY A 450
ASN A  40
 GLC  A 468 ( 4.8A)
None
GLC  A 468 ( 4.0A)
AMP  A1472 ( 3.7A)
GLC  A 468 ( 4.1A)
 1.24A 2zw9A-4b8sA:
2.1		 2zw9A-4b8sA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 8 ARG A 109
TYR A 185
ASP A 212
GLU A 102
 None
 1.29A 3dh0A-4b8sA:
3.8		 3dh0A-4b8sA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 GLY A  84
TYR A 107
LEU A 108
VAL A  99
LEU A  52
 None
 1.29A 3g9eA-4b8sA:
undetectable		 3g9eA-4b8sA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		3 / 3 GLU A 414
GLU A 419
TRP A  12
 None
 1.21A 3hrdA-4b8sA:
undetectable
3hrdE-4b8sA:
undetectable
3hrdF-4b8sA:
undetectable		 3hrdA-4b8sA:
22.56
3hrdE-4b8sA:
22.56
3hrdF-4b8sA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 9 ALA A 210
VAL A 104
ILE A  85
LEU A  82
ILE A  75
 None
 1.24A 3jw3B-4b8sA:
undetectable		 3jw3B-4b8sA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 11 SER A 376
TYR A 133
ILE A 453
ALA A 457
SER A 460
 None
 1.09A 3n8yA-4b8sA:
undetectable		 3n8yA-4b8sA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ALA A 378
SER A 456
ASN A  29
LEU A  24
PHE A 374
 None
 1.21A 3nrrA-4b8sA:
undetectable		 3nrrA-4b8sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ALA A 378
SER A 456
ASN A  29
LEU A  24
PHE A 374
 None
 1.23A 3nrrB-4b8sA:
undetectable		 3nrrB-4b8sA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ALA A 215
PHE A 206
ILE A 207
LEU A  81
VAL A  99
 None
None
GLC  A 468 ( 4.3A)
None
None
 1.11A 3o7wA-4b8sA:
2.5		 3o7wA-4b8sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 11 ILE A 330
GLY A 328
GLU A 306
ARG A 405
THR A 353
 None
 1.07A 3r76A-4b8sA:
4.2		 3r76A-4b8sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 11 ILE A 330
GLY A 328
GLU A 306
ARG A 405
THR A 353
 None
 1.07A 3r76B-4b8sA:
4.2		 3r76B-4b8sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 7 VAL A 302
LEU A 309
MET A 313
ILE A 312
 None
 0.82A 3rfmA-4b8sA:
undetectable		 3rfmA-4b8sA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 HIS A 350
GLY A 303
GLY A 450
SER A 454
ALA A 375
 None
GOL  A1468 (-4.5A)
AMP  A1472 ( 3.7A)
GOL  A1468 ( 4.5A)
None
 1.27A 3sueD-4b8sA:
undetectable		 3sueD-4b8sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		6 / 12 ASP A  42
GLY A 119
GLY A 120
ARG A 205
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.69A 3uboA-4b8sA:
23.1		 3uboA-4b8sA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.40A 3uq6A-4b8sA:
22.8		 3uq6A-4b8sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.45A 3vaqA-4b8sA:
22.8		 3vaqA-4b8sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.41A 3vasA-4b8sA:
21.2		 3vasA-4b8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.47A 3vasB-4b8sA:
21.7		 3vasB-4b8sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 LEU A 266
LEU A 269
ASN A 270
VAL A  33
THR A 300
 None
None
None
None
GOL  A1469 (-4.5A)
 0.94A 3zqtA-4b8sA:
undetectable		 3zqtA-4b8sA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.43A 4dc3B-4b8sA:
22.9		 4dc3B-4b8sA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.39A 4e3aB-4b8sA:
23.6		 4e3aB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.44A 4jksA-4b8sA:
23.6		 4jksA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.43A 4jksB-4b8sA:
23.6		 4jksB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.44A 4jkuA-4b8sA:
23.5		 4jkuA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.42A 4k8cA-4b8sA:
23.6		 4k8cA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.42A 4k8cB-4b8sA:
23.6		 4k8cB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.45A 4k8kA-4b8sA:
23.6		 4k8kA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.45A 4k8kB-4b8sA:
23.6		 4k8kB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.42A 4kahA-4b8sA:
23.6		 4kahA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.41A 4kahB-4b8sA:
23.6		 4kahB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.44A 4kalA-4b8sA:
23.5		 4kalA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.44A 4kalB-4b8sA:
23.5		 4kalB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.43A 4kanA-4b8sA:
23.7		 4kanA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.42A 4kanB-4b8sA:
23.6		 4kanB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.42A 4kbeA-4b8sA:
23.7		 4kbeA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.40A 4kbeB-4b8sA:
23.6		 4kbeB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.44A 4lbgA-4b8sA:
23.5		 4lbgA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.43A 4lbgB-4b8sA:
23.6		 4lbgB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.41A 4lcaA-4b8sA:
23.4		 4lcaA-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
ILE A 186
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
None
GLC  A 468 (-2.9A)
 0.41A 4lcaB-4b8sA:
23.5		 4lcaB-4b8sA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ILE A 135
LEU A 129
PHE A 223
ALA A 237
LEU A 236
 None
 1.07A 4o1zB-4b8sA:
0.9		 4o1zB-4b8sA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 8 ILE A 135
LYS A  31
ILE A  27
ASN A  29
ALA A  26
 None
None
None
None
GOL  A1470 ( 3.8A)
 1.43A 4ou1A-4b8sA:
3.0		 4ou1A-4b8sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 VAL A 139
LEU A 242
SER A 240
ALA A 122
PHE A 299
 None
 1.47A 4qdcA-4b8sA:
undetectable		 4qdcA-4b8sA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 5 PHE A 152
HIS A 140
LEU A  35
PRO A 172
 None
 1.37A 5csyB-4b8sA:
undetectable		 5csyB-4b8sA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ALA A 281
GLU A 308
MET A 125
ILE A 124
GLY A 120
 GOL  A1468 ( 3.9A)
GOL  A1468 (-2.9A)
None
None
GLC  A 468 (-3.6A)
 0.96A 5gs4A-4b8sA:
undetectable		 5gs4A-4b8sA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		6 / 12 ALA A 359
THR A 361
LEU A 432
GLY A 423
LEU A 424
GLY A 365
 None
 1.29A 5h2uA-4b8sA:
undetectable		 5h2uA-4b8sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 9 LEU A 340
ILE A 346
ILE A 315
GLU A 319
GLU A 308
 None
None
None
None
GOL  A1468 (-2.9A)
 1.43A 5igzA-4b8sA:
undetectable		 5igzA-4b8sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 ASP A  42
GLY A 119
GLY A 120
GLY A 448
ASP A 451
 GLC  A 468 (-2.7A)
GLC  A 468 (-3.5A)
GLC  A 468 (-3.6A)
GLC  A 468 ( 4.0A)
GLC  A 468 (-2.9A)
 0.37A 5kb5A-4b8sA:
23.3		 5kb5A-4b8sA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 6 ILE A 439
ALA A 380
ILE A 449
TYR A 357
 AMP  A1472 ( 4.3A)
None
AMP  A1472 (-3.7A)
None
 0.76A 5mvmB-4b8sA:
undetectable
5mvmC-4b8sA:
undetectable		 5mvmB-4b8sA:
8.87
5mvmC-4b8sA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 LEU A 304
VAL A 307
TYR A 282
ILE A 449
ALA A 379
 None
None
None
AMP  A1472 (-3.7A)
AMP  A1472 ( 4.4A)
 0.83A 5n5dB-4b8sA:
3.8		 5n5dB-4b8sA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 8 ASN A  70
ARG A  87
ILE A  67
GLY A  84
 None
 0.98A 5nzxA-4b8sA:
1.2		 5nzxA-4b8sA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		4 / 6 ASN A 214
ALA A 215
VAL A 217
ASP A 211
 None
 1.22A 5umd2-4b8sA:
undetectable
5umdF-4b8sA:
undetectable		 5umd2-4b8sA:
9.96
5umdF-4b8sA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 241
ASP A 451
GLY A 119
ASN A  40
ILE A 124
 None
GLC  A 468 (-2.9A)
GLC  A 468 (-3.5A)
GLC  A 468 ( 4.1A)
None
 0.76A 5vopA-4b8sA:
3.0		 5vopA-4b8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 12 GLY A 241
ASP A 451
GLY A 119
ASN A  40
ILE A 124
 None
GLC  A 468 (-2.9A)
GLC  A 468 (-3.5A)
GLC  A 468 ( 4.1A)
None
 0.81A 5vopB-4b8sA:
2.8		 5vopB-4b8sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		3 / 3 LYS A  90
LEU A  91
ARG A  87
 None
 0.67A 5yw0A-4b8sA:
undetectable		 5yw0A-4b8sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 9 ILE A 135
SER A 276
SER A 460
GLY A 463
THR A 137
 None
 1.27A 6awpA-4b8sA:
undetectable		 6awpA-4b8sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4b8s ADP-DEPENDENT
GLUCOKINASE
(Thermococcus
litoralis) 		5 / 9 ILE A 135
SER A 454
SER A 460
GLY A 463
THR A 137
 None
GOL  A1468 ( 4.5A)
None
None
None
 1.16A 6awpA-4b8sA:
undetectable		 6awpA-4b8sA:
22.43