SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 8 PHE A 280
GLY A 278
LEU A  76
VAL A 187
 None
None
GDP  A 901 (-3.8A)
GDP  A 901 (-3.6A)
 1.03A 1gsfC-4b8wA:
undetectable		 1gsfC-4b8wA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		5 / 12 THR A  13
VAL A  12
TRP A  38
ALA A 101
VAL A  97
 None
 1.11A 1jg4A-4b8wA:
undetectable		 1jg4A-4b8wA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		5 / 12 ASP A  45
ALA A 101
SER A 100
GLY A  14
HIS A  68
 None
None
None
NAP  A 900 (-3.0A)
None
 1.15A 1nbiA-4b8wA:
4.0		 1nbiA-4b8wA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A 241
LEU A 289
SER A 287
ARG A 290
 None
 0.97A 2byoA-4b8wA:
undetectable		 2byoA-4b8wA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A 226
GLU A 128
ILE A 169
PRO A 170
 None
None
None
NAP  A 900 ( 4.4A)
 1.03A 2fcnA-4b8wA:
undetectable
2fcnB-4b8wA:
undetectable		 2fcnA-4b8wA:
15.64
2fcnB-4b8wA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 8 HIS A 186
GLY A  75
ASN A  79
TYR A 143
 NAP  A 900 ( 3.4A)
GDP  A 901 (-3.1A)
None
None
 1.39A 3ccfA-4b8wA:
3.0		 3ccfA-4b8wA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 5 ILE A 150
HIS A  68
VAL A  97
ASN A  94
 None
 0.98A 3nneA-4b8wA:
0.4		 3nneA-4b8wA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 6 ILE A 150
HIS A  68
VAL A  97
ASN A  94
 None
 1.01A 3nneG-4b8wA:
undetectable		 3nneG-4b8wA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 6 ILE A 169
GLU A 128
ALA A 284
ASN A 286
 None
 1.12A 3pgyA-4b8wA:
2.7
3pgyB-4b8wA:
3.3		 3pgyA-4b8wA:
22.04
3pgyB-4b8wA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 240
ALA A 167
PRO A 119
ILE A 241
THR A 166
 None
 1.18A 4g8zX-4b8wA:
undetectable		 4g8zX-4b8wA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 6 VAL A 110
VAL A 168
ILE A 240
TRP A 229
 None
 0.94A 4l1wB-4b8wA:
undetectable		 4l1wB-4b8wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 5 SER A 111
ALA A 167
HIS A  68
LEU A  98
 None
 1.43A 5dzkb-4b8wA:
2.0
5dzkp-4b8wA:
undetectable		 5dzkb-4b8wA:
20.18
5dzkp-4b8wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 5 SER A 111
ALA A 167
HIS A  68
LEU A  98
 None
 1.47A 5dzkc-4b8wA:
0.8
5dzkq-4b8wA:
undetectable		 5dzkc-4b8wA:
20.18
5dzkq-4b8wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 5 VAL A 168
THR A 166
LEU A 223
VAL A  26
 None
 1.00A 6bqgA-4b8wA:
undetectable		 6bqgA-4b8wA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 7 ASN A  96
GLY A  14
VAL A  61
LEU A  57
 None
NAP  A 900 (-3.0A)
None
None
 0.74A 6dwnB-4b8wA:
undetectable		 6dwnB-4b8wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 4 ASP A 151
ILE A 169
PRO A 170
LEU A 113
 None
None
NAP  A 900 ( 4.4A)
None
 1.26A 6mkeB-4b8wA:
undetectable		 6mkeB-4b8wA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4b8w GDP-L-FUCOSE
SYNTHASE
(Homo
sapiens) 		4 / 4 ASP A 151
ILE A 169
PRO A 170
LEU A 113
 None
None
NAP  A 900 ( 4.4A)
None
 1.29A 6mkeA-4b8wA:
undetectable		 6mkeA-4b8wA:
13.36