SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 12 LEU A 134
ASP A  47
LEU A  43
GLY A  44
ALA A  58
 None
 1.11A 1hvyD-4b8xA:
undetectable		 1hvyD-4b8xA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 LEU A  83
ARG A  59
LEU A  97
VAL A 127
 None
 0.82A 2po5B-4b8xA:
undetectable		 2po5B-4b8xA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 8 THR A 115
VAL A  90
THR A  91
VAL A  98
 None
 0.87A 2qbmA-4b8xA:
undetectable		 2qbmA-4b8xA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		3 / 3 LEU A  66
VAL A 126
ARG A 124
 None
 0.84A 3b0wB-4b8xA:
undetectable		 3b0wB-4b8xA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 6 LEU A  55
VAL A  50
VAL A 127
PHE A 139
 None
 1.03A 3soaA-4b8xA:
undetectable		 3soaA-4b8xA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4b8x POSSIBLE
MARR-TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 VAL A 126
GLU A 125
GLY A 123
LEU A 102
 None
 1.09A 5g5gC-4b8xA:
undetectable		 5g5gC-4b8xA:
12.04