SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 VAL A 357
TRP A 359
TRP A 405
 None
 1.43A 1c4dA-4b90A:
undetectable
1c4dB-4b90A:
undetectable		 1c4dA-4b90A:
3.52
1c4dB-4b90A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 GLU A 270
THR A 272
HIS A 275
HIS A  68
 None
 1.39A 1d4fA-4b90A:
undetectable		 1d4fA-4b90A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 GLU A 270
THR A 272
HIS A 275
HIS A  68
 None
 1.31A 1d4fD-4b90A:
undetectable		 1d4fD-4b90A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 9 ASP A 399
GLY A  61
ILE A  59
VAL A  28
ILE A  35
 None
 1.10A 1hxwA-4b90A:
undetectable		 1hxwA-4b90A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 11 LEU A 245
ALA A 192
ALA A 236
LEU A 174
VAL A 267
 None
 1.12A 1ictA-4b90A:
undetectable
1ictC-4b90A:
undetectable		 1ictA-4b90A:
13.10
1ictC-4b90A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 PHE A 467
ARG A 189
ASN A 155
 None
 0.93A 1xzxX-4b90A:
undetectable		 1xzxX-4b90A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.14A 1zzrA-4b90A:
undetectable
1zzrB-4b90A:
undetectable		 1zzrA-4b90A:
21.10
1zzrB-4b90A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.15A 1zzrA-4b90A:
undetectable
1zzrB-4b90A:
undetectable		 1zzrA-4b90A:
21.10
1zzrB-4b90A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.10A 1zzuA-4b90A:
0.1
1zzuB-4b90A:
undetectable		 1zzuA-4b90A:
21.10
1zzuB-4b90A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.12A 1zzuA-4b90A:
0.1
1zzuB-4b90A:
undetectable		 1zzuA-4b90A:
21.10
1zzuB-4b90A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		6 / 12 GLY A 397
ALA A 398
ASP A 399
ASP A 401
VAL A  17
ILE A 394
 None
 1.36A 2bpxB-4b90A:
undetectable		 2bpxB-4b90A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 LEU A 314
GLU A 270
ALA A 276
THR A 277
 None
 1.03A 2roxB-4b90A:
undetectable		 2roxB-4b90A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.10A 2vmyA-4b90A:
undetectable
2vmyB-4b90A:
undetectable		 2vmyA-4b90A:
21.50
2vmyB-4b90A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ALA A 276
LEU A 278
THR A 272
VAL A 322
 None
 1.01A 3d2tB-4b90A:
undetectable		 3d2tB-4b90A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.18A 3dqrA-4b90A:
undetectable
3dqrB-4b90A:
undetectable		 3dqrA-4b90A:
20.09
3dqrB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ASN A 429
ASP A 353
GLN A 352
 None
 0.71A 3eeyC-4b90A:
undetectable		 3eeyC-4b90A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ASN A 429
ASP A 353
GLN A 352
 None
 0.71A 3eeyD-4b90A:
undetectable		 3eeyD-4b90A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ASN A 429
ASP A 353
GLN A 352
 None
 0.71A 3eeyE-4b90A:
undetectable		 3eeyE-4b90A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 CYH A 432
PRO A 436
ASP A 353
 None
 0.97A 3hlwB-4b90A:
undetectable		 3hlwB-4b90A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.08A 3jx2A-4b90A:
undetectable
3jx2B-4b90A:
undetectable		 3jx2A-4b90A:
20.09
3jx2B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.17A 3jx2A-4b90A:
undetectable
3jx2B-4b90A:
undetectable		 3jx2A-4b90A:
20.09
3jx2B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.11A 3jx3A-4b90A:
0.1
3jx3B-4b90A:
undetectable		 3jx3A-4b90A:
20.09
3jx3B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.14A 3jx3A-4b90A:
0.1
3jx3B-4b90A:
undetectable		 3jx3A-4b90A:
20.09
3jx3B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.20A 3jx4A-4b90A:
0.3
3jx4B-4b90A:
undetectable		 3jx4A-4b90A:
20.09
3jx4B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.10A 3jx5A-4b90A:
undetectable
3jx5B-4b90A:
0.2		 3jx5A-4b90A:
20.09
3jx5B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.20A 3jx5A-4b90A:
undetectable
3jx5B-4b90A:
0.2		 3jx5A-4b90A:
20.09
3jx5B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.09A 3jx6A-4b90A:
undetectable
3jx6B-4b90A:
undetectable		 3jx6A-4b90A:
20.48
3jx6B-4b90A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.14A 3jx6A-4b90A:
undetectable
3jx6B-4b90A:
undetectable		 3jx6A-4b90A:
20.48
3jx6B-4b90A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.09A 3nljA-4b90A:
0.1
3nljB-4b90A:
undetectable		 3nljA-4b90A:
20.48
3nljB-4b90A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.18A 3nljA-4b90A:
0.1
3nljB-4b90A:
undetectable		 3nljA-4b90A:
20.48
3nljB-4b90A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.10A 3nlpA-4b90A:
undetectable
3nlpB-4b90A:
undetectable		 3nlpA-4b90A:
20.09
3nlpB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.21A 3nlpA-4b90A:
undetectable
3nlpB-4b90A:
undetectable		 3nlpA-4b90A:
20.09
3nlpB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.05A 3nlqA-4b90A:
undetectable
3nlqB-4b90A:
undetectable		 3nlqA-4b90A:
20.09
3nlqB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.12A 3nlqA-4b90A:
undetectable
3nlqB-4b90A:
undetectable		 3nlqA-4b90A:
20.09
3nlqB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.07A 3nlrA-4b90A:
undetectable
3nlrB-4b90A:
0.3		 3nlrA-4b90A:
20.09
3nlrB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE A 373
GLY A  92
ILE A  59
VAL A 403
 None
 0.88A 3wrkA-4b90A:
undetectable		 3wrkA-4b90A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE A 373
GLY A  92
THR A 439
VAL A 403
 None
 1.05A 3wrkD-4b90A:
undetectable		 3wrkD-4b90A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 TYR A  83
GLY A  85
ALA A  88
SER A 441
GLU A 456
 None
 1.35A 4bupA-4b90A:
undetectable		 4bupA-4b90A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.13A 4cx3A-4b90A:
undetectable
4cx3B-4b90A:
undetectable		 4cx3A-4b90A:
20.09
4cx3B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.13A 4cx3A-4b90A:
undetectable
4cx3B-4b90A:
undetectable		 4cx3A-4b90A:
20.09
4cx3B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.15A 4cx4A-4b90A:
undetectable
4cx4B-4b90A:
undetectable		 4cx4A-4b90A:
20.09
4cx4B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.16A 4cx4A-4b90A:
undetectable
4cx4B-4b90A:
undetectable		 4cx4A-4b90A:
20.09
4cx4B-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 ILE A  98
ARG A 189
VAL A 351
MET A 355
 None
 1.00A 4f4dA-4b90A:
undetectable		 4f4dA-4b90A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 ILE A  98
ARG A 189
VAL A 351
MET A 355
 None
 0.99A 4f4dB-4b90A:
undetectable		 4f4dB-4b90A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ARG A 189
HIS A 131
TYR A 244
 None
 1.36A 4fu9A-4b90A:
undetectable		 4fu9A-4b90A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 10 PHE A 373
GLY A  92
THR A 439
ILE A  59
VAL A 403
 None
 1.07A 4jx1B-4b90A:
undetectable		 4jx1B-4b90A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A  57
VAL A  58
PRO A  60
GLU A 370
 None
 0.99A 4lb2A-4b90A:
undetectable		 4lb2A-4b90A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 TYR A 284
THR A 271
LEU A 310
THR A 304
 None
 1.47A 4mbsB-4b90A:
undetectable		 4mbsB-4b90A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ASP A 399
ALA A 129
TYR A 128
ASP A 401
 None
 1.05A 4mdaA-4b90A:
undetectable		 4mdaA-4b90A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ASP A 399
ALA A 129
TYR A 128
ASP A 401
 None
 1.05A 4mdbA-4b90A:
undetectable		 4mdbA-4b90A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 11 ILE A 243
LEU A 245
ALA A 269
HIS A 240
LEU A 475
 None
 1.17A 4nqaA-4b90A:
undetectable		 4nqaA-4b90A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 CYH A 432
PRO A 436
ASP A 353
 None
 0.98A 4pm5A-4b90A:
undetectable		 4pm5A-4b90A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.02A 4qvnV-4b90A:
undetectable
4qvnb-4b90A:
undetectable		 4qvnV-4b90A:
18.02
4qvnb-4b90A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.01A 4qvnH-4b90A:
undetectable
4qvnN-4b90A:
undetectable		 4qvnH-4b90A:
18.02
4qvnN-4b90A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 THR A  86
GLY A  93
GLY A  92
VAL A  91
 None
 0.82A 4qvvK-4b90A:
undetectable
4qvvL-4b90A:
undetectable		 4qvvK-4b90A:
17.45
4qvvL-4b90A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 THR A  86
GLY A  93
GLY A  92
VAL A  91
 None
 0.81A 4qvvY-4b90A:
undetectable
4qvvZ-4b90A:
undetectable		 4qvvY-4b90A:
17.45
4qvvZ-4b90A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.13A 5addA-4b90A:
undetectable
5addB-4b90A:
undetectable		 5addA-4b90A:
20.09
5addB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A 278
ALA A 276
LEU A 300
VAL A 322
 None
 1.12A 5cr1A-4b90A:
undetectable		 5cr1A-4b90A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.18A 5g0pA-4b90A:
undetectable
5g0pB-4b90A:
undetectable		 5g0pA-4b90A:
20.09
5g0pB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.17A 5g0pA-4b90A:
undetectable
5g0pB-4b90A:
undetectable		 5g0pA-4b90A:
20.09
5g0pB-4b90A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.03A 5lf7V-4b90A:
undetectable
5lf7b-4b90A:
undetectable		 5lf7V-4b90A:
18.91
5lf7b-4b90A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.04A 5lf7H-4b90A:
undetectable
5lf7N-4b90A:
undetectable		 5lf7H-4b90A:
18.91
5lf7N-4b90A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A  93
ASP A 401
LEU A 385
GLY A 392
PHE A 373
 None
 1.13A 5vooD-4b90A:
8.3		 5vooD-4b90A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A  93
ASP A 401
LEU A 385
GLY A 392
PHE A 373
 None
 1.14A 5vooF-4b90A:
5.2		 5vooF-4b90A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ASP A 207
GLY A 212
PRO A 213
GLY A 215
 None
 0.71A 6ag0C-4b90A:
3.9		 6ag0C-4b90A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.02A 6hwdV-4b90A:
undetectable
6hwdb-4b90A:
undetectable		 6hwdV-4b90A:
11.52
6hwdb-4b90A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.02A 6hwdH-4b90A:
undetectable
6hwdN-4b90A:
undetectable		 6hwdH-4b90A:
11.52
6hwdN-4b90A:
10.72