SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 VAL A 357
TRP A 359
TRP A 405
 None
 1.40A 1c4dA-4b92A:
undetectable
1c4dB-4b92A:
undetectable		 1c4dA-4b92A:
3.52
1c4dB-4b92A:
3.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 GLU A 270
THR A 272
HIS A 275
HIS A  68
 None
 1.41A 1d4fA-4b92A:
undetectable		 1d4fA-4b92A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 GLU A 270
THR A 272
HIS A 275
HIS A  68
 None
 1.32A 1d4fD-4b92A:
undetectable		 1d4fD-4b92A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.16A 1eqbA-4b92A:
undetectable
1eqbB-4b92A:
undetectable		 1eqbA-4b92A:
23.09
1eqbB-4b92A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.14A 1eqbA-4b92A:
undetectable
1eqbB-4b92A:
undetectable		 1eqbA-4b92A:
23.09
1eqbB-4b92A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.16A 1eqbC-4b92A:
undetectable
1eqbD-4b92A:
undetectable		 1eqbC-4b92A:
23.09
1eqbD-4b92A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.15A 1eqbC-4b92A:
undetectable
1eqbD-4b92A:
undetectable		 1eqbC-4b92A:
23.09
1eqbD-4b92A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A  14
ALA A  53
ASP A  52
VAL A 438
VAL A 402
 None
 0.93A 1hsgB-4b92A:
undetectable		 1hsgB-4b92A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 9 ASP A 399
GLY A  61
ILE A  59
VAL A  28
ILE A  35
 None
 1.09A 1hxwA-4b92A:
undetectable		 1hxwA-4b92A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 11 LEU A 245
ALA A 192
ALA A 236
LEU A 174
VAL A 267
 None
 1.14A 1ictA-4b92A:
undetectable
1ictC-4b92A:
undetectable		 1ictA-4b92A:
14.38
1ictC-4b92A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		6 / 11 GLY A 397
ALA A 398
ASP A 399
ASP A 401
VAL A  17
ILE A 394
 None
 1.30A 1ohrA-4b92A:
undetectable		 1ohrA-4b92A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLY A 185
MET A 145
ILE A 187
PRO A 242
 None
 1.07A 1rxcL-4b92A:
undetectable		 1rxcL-4b92A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A  14
ALA A  53
ASP A  52
VAL A 438
VAL A 402
 None
 0.97A 1sdtB-4b92A:
undetectable		 1sdtB-4b92A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.17A 1zzrA-4b92A:
undetectable
1zzrB-4b92A:
undetectable		 1zzrA-4b92A:
22.55
1zzrB-4b92A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.18A 1zzrA-4b92A:
undetectable
1zzrB-4b92A:
undetectable		 1zzrA-4b92A:
22.55
1zzrB-4b92A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.13A 1zzuA-4b92A:
undetectable
1zzuB-4b92A:
undetectable		 1zzuA-4b92A:
22.55
1zzuB-4b92A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.16A 1zzuA-4b92A:
0.0
1zzuB-4b92A:
undetectable		 1zzuA-4b92A:
22.55
1zzuB-4b92A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		6 / 12 GLY A 397
ALA A 398
ASP A 399
ASP A 401
VAL A  17
ILE A 394
 None
 1.31A 2bpxB-4b92A:
undetectable		 2bpxB-4b92A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE A 373
VAL A 403
VAL A 435
THR A 273
LEU A 314
 None
 1.16A 2cbrA-4b92A:
undetectable		 2cbrA-4b92A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 LEU A 314
GLU A 270
ALA A 276
THR A 277
 None
 1.06A 2roxB-4b92A:
undetectable		 2roxB-4b92A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.18A 2vmyA-4b92A:
undetectable
2vmyB-4b92A:
undetectable		 2vmyA-4b92A:
21.70
2vmyB-4b92A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 SER A  66
HIS A 191
HIS A 100
ARG A 189
 None
 1.08A 2vmyA-4b92A:
undetectable
2vmyB-4b92A:
undetectable		 2vmyA-4b92A:
21.70
2vmyB-4b92A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ASP A  64
ILE A  63
LEU A 385
TYR A 244
 None
 1.08A 2ya7A-4b92A:
undetectable		 2ya7A-4b92A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 SER A   7
LEU A  11
GLY A  46
GLU A  31
 None
 1.09A 3aiaA-4b92A:
undetectable
3aiaB-4b92A:
undetectable		 3aiaA-4b92A:
17.77
3aiaB-4b92A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ALA A 276
LEU A 278
THR A 272
VAL A 322
 None
 1.03A 3d2tB-4b92A:
undetectable		 3d2tB-4b92A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.22A 3dqrA-4b92A:
undetectable
3dqrB-4b92A:
undetectable		 3dqrA-4b92A:
22.16
3dqrB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ASN A 429
ASP A 353
GLN A 352
 None
 0.79A 3eeyC-4b92A:
undetectable		 3eeyC-4b92A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ASN A 429
ASP A 353
GLN A 352
 None
 0.79A 3eeyD-4b92A:
undetectable		 3eeyD-4b92A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 ASN A 429
ASP A 353
GLN A 352
 None
 0.79A 3eeyE-4b92A:
undetectable		 3eeyE-4b92A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 CYH A 432
PRO A 436
ASP A 353
 None
 0.94A 3hlwB-4b92A:
undetectable		 3hlwB-4b92A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.12A 3jx2A-4b92A:
undetectable
3jx2B-4b92A:
undetectable		 3jx2A-4b92A:
22.16
3jx2B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.19A 3jx2A-4b92A:
undetectable
3jx2B-4b92A:
undetectable		 3jx2A-4b92A:
22.16
3jx2B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.14A 3jx3A-4b92A:
undetectable
3jx3B-4b92A:
undetectable		 3jx3A-4b92A:
22.16
3jx3B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.16A 3jx3A-4b92A:
undetectable
3jx3B-4b92A:
undetectable		 3jx3A-4b92A:
22.16
3jx3B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.22A 3jx4A-4b92A:
undetectable
3jx4B-4b92A:
undetectable		 3jx4A-4b92A:
22.16
3jx4B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.12A 3jx5A-4b92A:
undetectable
3jx5B-4b92A:
undetectable		 3jx5A-4b92A:
22.16
3jx5B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.22A 3jx5A-4b92A:
undetectable
3jx5B-4b92A:
undetectable		 3jx5A-4b92A:
22.16
3jx5B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.11A 3jx6A-4b92A:
undetectable
3jx6B-4b92A:
undetectable		 3jx6A-4b92A:
22.16
3jx6B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.15A 3jx6A-4b92A:
undetectable
3jx6B-4b92A:
undetectable		 3jx6A-4b92A:
22.16
3jx6B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.12A 3nljA-4b92A:
undetectable
3nljB-4b92A:
undetectable		 3nljA-4b92A:
22.16
3nljB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.19A 3nljA-4b92A:
undetectable
3nljB-4b92A:
undetectable		 3nljA-4b92A:
22.16
3nljB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.13A 3nlpA-4b92A:
undetectable
3nlpB-4b92A:
undetectable		 3nlpA-4b92A:
22.16
3nlpB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.23A 3nlpA-4b92A:
undetectable
3nlpB-4b92A:
undetectable		 3nlpA-4b92A:
22.16
3nlpB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.08A 3nlqA-4b92A:
undetectable
3nlqB-4b92A:
undetectable		 3nlqA-4b92A:
22.16
3nlqB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.14A 3nlqA-4b92A:
undetectable
3nlqB-4b92A:
undetectable		 3nlqA-4b92A:
22.16
3nlqB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.10A 3nlrA-4b92A:
undetectable
3nlrB-4b92A:
undetectable		 3nlrA-4b92A:
22.16
3nlrB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 10 GLY A  14
ALA A  53
ASP A  52
VAL A 438
VAL A 402
 None
 0.97A 3oxwA-4b92A:
undetectable		 3oxwA-4b92A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 TYR A  83
GLY A  85
ALA A  88
SER A 441
GLU A 456
 None
 1.43A 3s8pA-4b92A:
undetectable		 3s8pA-4b92A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 TYR A  83
GLY A  85
ALA A  88
SER A 441
GLU A 456
 None
 1.41A 3s8pB-4b92A:
undetectable		 3s8pB-4b92A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE A 373
GLY A  92
ILE A  59
VAL A 403
 None
 0.81A 3wrkA-4b92A:
undetectable		 3wrkA-4b92A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 PHE A 373
GLY A  92
THR A 439
VAL A 403
 None
 1.01A 3wrkD-4b92A:
undetectable		 3wrkD-4b92A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 TYR A  83
GLY A  85
ALA A  88
SER A 441
GLU A 456
 None
 1.38A 4bupA-4b92A:
undetectable		 4bupA-4b92A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 TYR A  83
GLY A  85
ALA A  88
SER A 441
GLU A 456
 None
 1.38A 4bupB-4b92A:
undetectable		 4bupB-4b92A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.16A 4cx3A-4b92A:
undetectable
4cx3B-4b92A:
undetectable		 4cx3A-4b92A:
22.16
4cx3B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.17A 4cx3A-4b92A:
undetectable
4cx3B-4b92A:
undetectable		 4cx3A-4b92A:
22.16
4cx3B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.19A 4cx4A-4b92A:
undetectable
4cx4B-4b92A:
undetectable		 4cx4A-4b92A:
22.16
4cx4B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.19A 4cx4A-4b92A:
undetectable
4cx4B-4b92A:
undetectable		 4cx4A-4b92A:
22.16
4cx4B-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 ILE A  98
ARG A 189
VAL A 351
MET A 355
 None
 1.01A 4f4dA-4b92A:
undetectable		 4f4dA-4b92A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 ILE A  98
ARG A 189
VAL A 351
MET A 355
 None
 1.00A 4f4dB-4b92A:
undetectable		 4f4dB-4b92A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 10 PHE A 373
GLY A  92
THR A 439
ILE A  59
VAL A 403
 None
 1.00A 4jx1B-4b92A:
undetectable		 4jx1B-4b92A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 LEU A  57
VAL A  58
PRO A  60
GLU A 370
 None
 1.00A 4lb2A-4b92A:
undetectable		 4lb2A-4b92A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 8 GLY A 212
ILE A 218
GLU A 204
LEU A 208
 None
 0.82A 4mwzB-4b92A:
undetectable		 4mwzB-4b92A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		3 / 3 CYH A 432
PRO A 436
ASP A 353
 None
 0.93A 4pm5A-4b92A:
undetectable		 4pm5A-4b92A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.05A 4qvnV-4b92A:
undetectable
4qvnb-4b92A:
undetectable		 4qvnV-4b92A:
19.04
4qvnb-4b92A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.04A 4qvnH-4b92A:
undetectable
4qvnN-4b92A:
undetectable		 4qvnH-4b92A:
19.04
4qvnN-4b92A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.15A 5addA-4b92A:
undetectable
5addB-4b92A:
undetectable		 5addA-4b92A:
22.16
5addB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.19A 5adeA-4b92A:
undetectable
5adeB-4b92A:
undetectable		 5adeA-4b92A:
22.16
5adeB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 5 LEU A 278
ALA A 276
LEU A 300
VAL A 322
 None
 1.14A 5cr1A-4b92A:
undetectable		 5cr1A-4b92A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 6 ILE A 358
ALA A 375
THR A 377
VAL A 376
VAL A 363
 None
 1.38A 5eclD-4b92A:
undetectable		 5eclD-4b92A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 VAL A 110
ARG A 150
VAL A 154
GLU A 144
 None
 1.20A 5g0pA-4b92A:
undetectable
5g0pB-4b92A:
undetectable		 5g0pA-4b92A:
22.16
5g0pB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 7 GLU A 144
VAL A 110
ARG A 150
VAL A 154
 None
 1.19A 5g0pA-4b92A:
undetectable
5g0pB-4b92A:
undetectable		 5g0pA-4b92A:
22.16
5g0pB-4b92A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		6 / 12 GLY A 397
ALA A 398
ASP A 399
ASP A 401
VAL A  17
ILE A 394
 None
 1.32A 5kqxA-4b92A:
undetectable		 5kqxA-4b92A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.06A 5lf7V-4b92A:
undetectable
5lf7b-4b92A:
undetectable		 5lf7V-4b92A:
19.92
5lf7b-4b92A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.06A 5lf7H-4b92A:
undetectable
5lf7N-4b92A:
undetectable		 5lf7H-4b92A:
19.92
5lf7N-4b92A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A  93
ASP A 401
LEU A 385
GLY A 392
PHE A 373
 None
 1.13A 5vooD-4b92A:
8.4		 5vooD-4b92A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 GLY A  93
ASP A 401
LEU A 385
GLY A 392
PHE A 373
 None
 1.14A 5vooF-4b92A:
8.4		 5vooF-4b92A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		4 / 6 ASP A 207
GLY A 212
PRO A 213
GLY A 215
 None
 0.73A 6ag0C-4b92A:
4.6		 6ag0C-4b92A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.04A 6hwdV-4b92A:
undetectable
6hwdb-4b92A:
undetectable		 6hwdV-4b92A:
12.94
6hwdb-4b92A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens) 		5 / 12 THR A 273
THR A 272
THR A 271
ALA A 276
THR A  94
 None
 1.04A 6hwdH-4b92A:
undetectable
6hwdN-4b92A:
undetectable		 6hwdH-4b92A:
12.94
6hwdN-4b92A:
11.69