SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b93'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Mus
musculus) 		4 / 8 VAL A   8
TYR A  62
ASP A  58
LEU A  33
 None
 1.24A 1pk2A-4b93A:
undetectable		 1pk2A-4b93A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Mus
musculus) 		4 / 8 PHE A  86
ALA A  94
ARG A  93
LEU A  15
 None
 1.03A 2bxkA-4b93A:
1.3		 2bxkA-4b93A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Mus
musculus) 		4 / 8 LYS A  42
ILE A  55
GLU A 135
LYS A  83
 None
 0.86A 2j9dJ-4b93A:
undetectable
2j9dK-4b93A:
undetectable
2j9dL-4b93A:
undetectable		 2j9dJ-4b93A:
20.61
2j9dK-4b93A:
20.61
2j9dL-4b93A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Mus
musculus) 		4 / 8 LYS A  83
LYS A  42
ILE A  55
GLU A 135
 None
 0.88A 2j9dJ-4b93A:
undetectable
2j9dK-4b93A:
undetectable
2j9dL-4b93A:
undetectable		 2j9dJ-4b93A:
20.61
2j9dK-4b93A:
20.61
2j9dL-4b93A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Mus
musculus;
Homo
sapiens) 		4 / 5 ARG B 668
ASP A  68
GLU B 669
LYS B 672
 None
 1.31A 2xrzA-4b93B:
undetectable
2xrzB-4b93B:
undetectable		 2xrzA-4b93B:
19.57
2xrzB-4b93B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		6 / 12 LEU B 674
GLY B 771
ALA B 752
ILE B 760
LEU B 763
VAL B 737
 None
 1.31A 3adxB-4b93B:
undetectable		 3adxB-4b93B:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		6 / 12 GLY B 755
GLY B 680
LEU B 759
LEU B 781
ALA B 678
VAL B 677
 None
 1.44A 3av6A-4b93B:
1.7		 3av6A-4b93B:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Mus
musculus;
Homo
sapiens) 		3 / 3 ARG B 668
ARG B 675
ASP A  67
 None
 0.97A 3wipG-4b93B:
undetectable
3wipH-4b93B:
undetectable		 3wipG-4b93B:
20.27
3wipH-4b93B:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 5 LYS B 672
LEU B 673
GLU B 669
LEU B 735
 None
 0.99A 4k4yA-4b93B:
undetectable		 4k4yA-4b93B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 4 LYS B 672
LEU B 673
GLU B 669
LEU B 735
 None
 0.99A 4k4yE-4b93B:
undetectable		 4k4yE-4b93B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 5 LYS B 672
LEU B 673
GLU B 669
LEU B 735
 None
 1.02A 4k4yI-4b93B:
undetectable		 4k4yI-4b93B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 6 LEU B 783
ASP B 743
VAL B 677
ALA B 678
 None
 0.96A 4nkxA-4b93B:
undetectable		 4nkxA-4b93B:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		3 / 3 THR B 740
SER B 741
TYR B 667
 None
 0.74A 5jsdA-4b93B:
undetectable		 5jsdA-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		3 / 3 THR B 740
SER B 741
TYR B 667
 None
 0.74A 5jsdB-4b93B:
undetectable		 5jsdB-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		3 / 3 THR B 740
SER B 741
TYR B 667
 None
 0.73A 5jsdC-4b93B:
undetectable		 5jsdC-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		3 / 3 THR B 740
SER B 741
TYR B 667
 None
 0.74A 5jseA-4b93B:
undetectable		 5jseA-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		3 / 3 THR B 740
SER B 741
TYR B 667
 None
 0.73A 5jseB-4b93B:
undetectable		 5jseB-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		3 / 3 THR B 740
SER B 741
TYR B 667
 None
 0.73A 5jseC-4b93B:
undetectable		 5jseC-4b93B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Mus
musculus) 		5 / 12 GLY A  48
GLU A 152
GLU A 155
LEU A 154
LEU A 146
 None
 1.34A 5nwvA-4b93A:
undetectable		 5nwvA-4b93A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Homo
sapiens;
Mus
musculus) 		4 / 6 ALA A 131
GLN A 132
LYS A 128
ASP B 679
 None
 1.27A 5y9aA-4b93A:
undetectable		 5y9aA-4b93A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4b93 VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7
(Mus
musculus) 		4 / 7 PHE A  78
LEU A  79
ALA A   6
GLN A 132
 None
 1.18A 6b89A-4b93A:
undetectable		 6b89A-4b93A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 6 LEU B 862
ALA B 867
THR B 812
ASN B 840
 None
 0.90A 6f88A-4b93B:
undetectable		 6f88A-4b93B:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
(Homo
sapiens) 		4 / 6 LEU B 862
ALA B 867
THR B 812
ASN B 840
 None
 0.96A 6f88B-4b93B:
undetectable		 6f88B-4b93B:
16.89