SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4b97'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 10 VAL A  26
SER A  61
ASN A  66
VAL A  67
GLY A  88
 None
 1.34A 2x2iD-4b97A:
2.7		 2x2iD-4b97A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A  47
ASN A 117
ASP A 121
TYR A  45
 None
None
CA  A1152 (-2.9A)
None
 0.97A 2zw9B-4b97A:
undetectable		 2zw9B-4b97A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A  85
PHE A  55
VAL A  67
ILE A 137
 None
 0.95A 3zjqA-4b97A:
undetectable		 3zjqA-4b97A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 VAL A  85
PHE A  55
VAL A  67
ILE A 137
 None
 0.94A 3zjqB-4b97A:
undetectable		 3zjqB-4b97A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 TYR A  84
ILE A  24
GLU A 150
TYR A 140
VAL A  26
 None
 1.34A 4a97A-4b97A:
undetectable
4a97B-4b97A:
undetectable		 4a97A-4b97A:
20.33
4a97B-4b97A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY A  80
ALA A  81
ASP A  82
ILE A  20
THR A 138
 None
 1.07A 4l1aA-4b97A:
undetectable		 4l1aA-4b97A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4b97 CELLULOSE BINDING
DOMAIN-CONTAINING
PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 7 TYR A  84
TYR A  44
GLN A  53
TYR A 140
 None
 1.34A 5ov9B-4b97A:
undetectable		 5ov9B-4b97A:
14.23